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    SLC30A9 solute carrier family 30 member 9 [ Homo sapiens (human) ]

    Gene ID: 10463, updated on 7-Apr-2024

    Summary

    Official Symbol
    SLC30A9provided by HGNC
    Official Full Name
    solute carrier family 30 member 9provided by HGNC
    Primary source
    HGNC:HGNC:1329
    See related
    Ensembl:ENSG00000014824 MIM:604604; AllianceGenome:HGNC:1329
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HUEL; ZNT9; GAC63; C4orf1; BILAPES
    Summary
    Predicted to enable nuclear receptor coactivator activity. Involved in cellular zinc ion homeostasis and zinc ion transport. Located in several cellular components, including cytoplasmic vesicle; cytoskeleton; and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney (RPKM 32.5), brain (RPKM 27.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SLC30A9 in Genome Data Viewer
    Location:
    4p13
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (41990530..42090461)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (41964357..42064385)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (41992547..42092478)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21510 Neighboring gene transmembrane protein 33 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:41983504-41984703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21511 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:41992428-41992647 Neighboring gene DDB1 and CUL4 associated factor 4 like 1 Neighboring gene ATPase Na+/K+ transporting subunit beta 1 pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:42138326-42138861 Neighboring gene BEN domain containing 4 Neighboring gene VISTA enhancer hs847 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:42153146-42153989 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15391 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:42263210-42263710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21513 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:42287227-42287728 Neighboring gene uncharacterized LOC124900697

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear receptor coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in intracellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular zinc ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nucleotide-excision repair TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitochondrion organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in zinc ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in zinc ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in zinc ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    proton-coupled zinc antiporter SLC30A9, mitochondrial
    Names
    GRIP1-dependent nuclear receptor coactivator
    expressed in human embryonic lung
    human embryonic lung protein
    solute carrier family 30 (zinc transporter), member 9
    zinc transporter 9
    znT-9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006345.4NP_006336.3  proton-coupled zinc antiporter SLC30A9, mitochondrial

      See identical proteins and their annotated locations for NP_006336.3

      Status: VALIDATED

      Source sequence(s)
      AA427879, AC113151, AY594282, BC007732, BC022981, BG323207
      Consensus CDS
      CCDS3465.1
      UniProtKB/Swiss-Prot
      Q4W5B6, Q6PML9, Q7Z5I7, Q8TBB2, Q9Y6R2
      UniProtKB/TrEMBL
      A0A0S2Z514, B2R745
      Related
      ENSP00000264451.6, ENST00000264451.12
      Conserved Domains (3) summary
      TIGR00598
      Location:124216
      rad14; DNA repair protein
      TIGR01297
      Location:254522
      CDF; cation diffusion facilitator family transporter
      pfam01545
      Location:251450
      Cation_efflux; Cation efflux family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      41990530..42090461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449525.1XP_047305481.1  proton-coupled zinc antiporter SLC30A9, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A0S2Z512

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      41964357..42064385
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348771.1XP_054204746.1  proton-coupled zinc antiporter SLC30A9, mitochondrial isoform X1