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    Bap1 Brca1 associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 104416, updated on 12-Mar-2019

    Summary

    Official Symbol
    Bap1provided by MGI
    Official Full Name
    Brca1 associated protein 1provided by MGI
    Primary source
    MGI:MGI:1206586
    See related
    Ensembl:ENSMUSG00000021901
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    uch-x4; AA989761; AW553466; mKIAA0272; 2300006C11Rik
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 33.4), testis adult (RPKM 31.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Bap1 in Genome Data Viewer
    Location:
    14; 14 B
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (31251454..31259930)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (32064675..32073115)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G Neighboring gene PHD finger protein 7 Neighboring gene dynein, axonemal, heavy chain 1 Neighboring gene predicted gene, 35823 Neighboring gene calpain 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    thiol-dependent ubiquitinyl hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    macrophage homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    monoubiquitinated histone H2A deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    monoubiquitinated protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cytokine production involved in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to inorganic substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    PR-DUB complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase BAP1
    Names
    BRCA1-associated protein 1
    ubiquitin C-terminal hydrolase X4
    NP_081364.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027088.2NP_081364.1  ubiquitin carboxyl-terminal hydrolase BAP1

      See identical proteins and their annotated locations for NP_081364.1

      Status: VALIDATED

      Source sequence(s)
      AK170576
      Consensus CDS
      CCDS26910.1
      UniProtKB/Swiss-Prot
      Q99PU7
      Related
      ENSMUSP00000022458.4, ENSMUST00000022458.10
      Conserved Domains (1) summary
      cd09617
      Location:5233
      Peptidase_C12_UCH37_BAP1; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5) and BAP1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      31251454..31259930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_383122.3 RNA Sequence

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