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    Blmh bleomycin hydrolase [ Mus musculus (house mouse) ]

    Gene ID: 104184, updated on 3-Feb-2019

    Summary

    Official Symbol
    Blmhprovided by MGI
    Official Full Name
    bleomycin hydrolaseprovided by MGI
    Primary source
    MGI:MGI:1345186
    See related
    Ensembl:ENSMUSG00000020840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bh; Bmh; AI035728
    Summary
    The encoded protein is a cytoplasmic cysteine peptidase involved in inactivation of bleomycin, a glycopeptide which is a component of combination chemotherapy regimens for cancer. This encoded enzyme is highly conserved, and it contains the signature active site residues of cysteine protease papain superfamily enzymes. It is postulated that this enzyme has protective effects against bleomycin-induced pulmonary fibrosis and bleomycin tumor resistance. [provided by RefSeq, Jan 2010]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 34.4), CNS E14 (RPKM 21.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See Blmh in Genome Data Viewer
    Location:
    11; 11 B5
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (76945656..76987389)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (76759158..76800891)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40200 Neighboring gene transmembrane and immunoglobulin domain containing 1 Neighboring gene solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 Neighboring gene predicted gene 12343 Neighboring gene nuclear speckle regulatory protein 1 Neighboring gene microRNA 423

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC36899, MGC37104, MGC39026

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    aminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    cysteine-type peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    homocysteine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to toxic substance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    bleomycin hydrolase
    Names
    BLM hydrolase
    NP_848760.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178645.4NP_848760.1  bleomycin hydrolase

      See identical proteins and their annotated locations for NP_848760.1

      Status: REVIEWED

      Source sequence(s)
      AK049461, BY087076, BY643607
      Consensus CDS
      CCDS25073.1
      UniProtKB/Swiss-Prot
      Q8R016
      Related
      ENSMUSP00000021197.3, ENSMUST00000021197.9
      Conserved Domains (1) summary
      pfam03051
      Location:5451
      Peptidase_C1_2; Peptidase C1-like family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      76945656..76987389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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