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    NMUR1 neuromedin U receptor 1 [ Homo sapiens (human) ]

    Gene ID: 10316, updated on 6-Jun-2024

    Summary

    Official Symbol
    NMUR1provided by HGNC
    Official Full Name
    neuromedin U receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:4518
    See related
    Ensembl:ENSG00000171596 MIM:604153; AllianceGenome:HGNC:4518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FM3; FM-3; GPC-R; GPR66; NMU1R; (FM-3)
    Summary
    Enables neuromedin U binding activity and neuromedin U receptor activity. Involved in several processes, including activation of phospholipase C activity; chloride transport; and second-messenger-mediated signaling. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in fat (RPKM 2.5), lung (RPKM 1.6) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NMUR1 in Genome Data Viewer
    Location:
    2q37.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (231518455..231530445, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (232002894..232014900, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (232387898..232395156, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, U2 small nuclear 22, pseudogene Neighboring gene long intergenic non-protein coding RNA 471 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:232378431-232379240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:232390957-232391458 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:232392564-232393091 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:232393092-232393618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12430 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:232396108-232396842 Neighboring gene uncharacterized LOC105376787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:232400385-232400886 Neighboring gene MPRA-validated peak4079 silencer Neighboring gene Sharpr-MPRA regulatory region 7070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17291 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17292 Neighboring gene ribosomal protein L21 pseudogene 35

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables neuromedin U binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables neuromedin U receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    neuromedin-U receptor 1
    Names
    G-protein coupled receptor 66
    G-protein coupled receptor FM-3
    NMU-R1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006056.5NP_006047.3  neuromedin-U receptor 1

      See identical proteins and their annotated locations for NP_006047.3

      Status: VALIDATED

      Source sequence(s)
      AC017104, AF272362, BP198644
      Consensus CDS
      CCDS2486.1
      UniProtKB/Swiss-Prot
      O43664, Q7LDP6, Q8NE20, Q9HB89
      Related
      ENSP00000305877.4, ENST00000305141.5
      Conserved Domains (1) summary
      pfam00001
      Location:77356
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      231518455..231530445 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006712195.4XP_006712258.1  neuromedin-U receptor 1 isoform X3

      UniProtKB/TrEMBL
      B4DTH8
      Conserved Domains (1) summary
      pfam00001
      Location:77249
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. XM_006712196.4XP_006712259.1  neuromedin-U receptor 1 isoform X4

      UniProtKB/TrEMBL
      B4DTH8
      Conserved Domains (1) summary
      pfam00001
      Location:77249
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    3. XM_011510488.3XP_011508790.1  neuromedin-U receptor 1 isoform X2

      Conserved Domains (1) summary
      pfam00001
      Location:77249
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    4. XM_011510489.3XP_011508791.1  neuromedin-U receptor 1 isoform X5

      UniProtKB/TrEMBL
      B4DTH8
      Conserved Domains (1) summary
      pfam00001
      Location:77249
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    5. XM_011510487.4XP_011508789.1  neuromedin-U receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_011508789.1

      UniProtKB/Swiss-Prot
      Q9HB89
      Conserved Domains (1) summary
      pfam00001
      Location:54333
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      232002894..232014900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340177.1XP_054196152.1  neuromedin-U receptor 1 isoform X3

      UniProtKB/TrEMBL
      B4DTH8
    2. XM_054340178.1XP_054196153.1  neuromedin-U receptor 1 isoform X4

      UniProtKB/TrEMBL
      B4DTH8
    3. XM_054340176.1XP_054196151.1  neuromedin-U receptor 1 isoform X2

    4. XM_054340179.1XP_054196154.1  neuromedin-U receptor 1 isoform X5

      UniProtKB/TrEMBL
      B4DTH8
    5. XM_054340175.1XP_054196150.1  neuromedin-U receptor 1 isoform X1