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    Oas1d 2'-5' oligoadenylate synthetase 1D [ Mus musculus (house mouse) ]

    Gene ID: 100535, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Oas1dprovided by MGI
    Official Full Name
    2'-5' oligoadenylate synthetase 1Dprovided by MGI
    Primary source
    MGI:MGI:2140770
    See related
    Ensembl:ENSMUSG00000032623 AllianceGenome:MGI:2140770
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    oasl8
    Summary
    Enables double-stranded RNA binding activity and enzyme inhibitor activity. Acts upstream of or within ovarian follicle development and ovulation from ovarian follicle. Located in cytoplasm. Is expressed in several structures, including genitourinary system; heart; liver; lung; and thymus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human OAS1 (2'-5'-oligoadenylate synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward ovary adult (RPKM 6.3) See more
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    Genomic context

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    See Oas1d in Genome Data Viewer
    Location:
    5 F; 5 60.87 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121052881..121059711)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (120914818..120921648)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14254 Neighboring gene 2'-5' oligoadenylate synthetase 1G Neighboring gene 2'-5' oligoadenylate synthetase 1A Neighboring gene 2'-5' oligoadenylate synthetase 1 pseudogene Neighboring gene rabphilin 3A Neighboring gene predicted gene, 32185 Neighboring gene STARR-positive B cell enhancer ABC_E3611 Neighboring gene protein tyrosine phosphatase, non-receptor type 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mice deficient in oocyte-specific oligoadenylate synthetase-like protein OAS1D display reduced fertility. Yan W, et al. Mol Cell Biol, 2005 Jun. PMID 15899864, Free PMC Article
    2. Structural and functional genomics and evolutionary relationships in the cluster of genes encoding murine 2',5'-oligoadenylate synthetases. Mashimo T, et al. Genomics, 2003 Nov. PMID 14559211
    3. Gene structure of the murine 2'-5'-oligoadenylate synthetase family. Eskildsen S, et al. Cell Mol Life Sci, 2002 Jul. PMID 12222967, Free PMC Article
    4. The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities. Kristiansen H, et al. J Interferon Cytokine Res, 2011 Jan. PMID 21142819
    5. Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family. Kakuta S, et al. J Interferon Cytokine Res, 2002 Sep. PMID 12396720

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. OAS1D suppresses the interferon/OAS/RNase L-mediated cellular destruction by interacting with OAS1A during oogenesis and early embryonic development.
      Title: Mice deficient in oocyte-specific oligoadenylate synthetase-like protein OAS1D display reduced fertility.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables 2'-5'-oligoadenylate synthetase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables 2'-5'-oligoadenylate synthetase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2'-5'-oligoadenylate synthetase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interferon-alpha ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryo development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interleukin-27-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of IP-10 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of chemokine (C-X-C motif) ligand 2 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral genome replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ovarian follicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ovulation from ovarian follicle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cellular respiration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of monocyte chemotactic protein-1 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein complex oligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in surfactant homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toll-like receptor 3 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in type I interferon-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inactive 2'-5'-oligoadenylate synthase 1D
    Names
    2',5'-oligoadenylate synthetase-like 8
    2'-5'olygoadenylate synthetase 1D

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133893.3 → NP_598654.1  inactive 2'-5'-oligoadenylate synthase 1D

      See identical proteins and their annotated locations for NP_598654.1

      Status: VALIDATED

      Source sequence(s)
      AK135783, DV659301
      Consensus CDS
      CCDS19631.1
      UniProtKB/Swiss-Prot
      Q3UWZ6, Q7TPY2, Q8VI95
      Related
      ENSMUSP00000048054.5, ENSMUST00000044224.5
      Conserved Domains (2) summary
      pfam10421
      Location:173 → 354
      OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
      cl11966
      Location:27 → 157
      NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      121052881..121059711
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VI95.1 GenPept UniProtKB/Swiss-Prot:Q8VI95

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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