U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Kbtbd11 kelch repeat and BTB (POZ) domain containing 11 [ Mus musculus (house mouse) ]

    Gene ID: 74901, updated on 30-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Kbtbd11provided by MGI
    Official Full Name
    kelch repeat and BTB (POZ) domain containing 11provided by MGI
    Primary source
    MGI:MGI:1922151
    See related
    Ensembl:ENSMUSG00000055675 AllianceGenome:MGI:1922151
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0711; 2900016B01Rik; 4930465M17Rik
    Summary
    Is expressed in several structures, including central nervous system; early tubule; ganglia; lung; and sensory organ. Orthologous to human KBTBD11 (kelch repeat and BTB domain containing 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in spleen adult (RPKM 21.9), mammary gland adult (RPKM 18.9) and 23 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    8 A1.1; 8 7.59 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (15059408..15083333)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (15011025..15033333)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 10 Neighboring gene STARR-positive B cell enhancer mm9_chr8:14961480-14961780 Neighboring gene predicted gene 16350 Neighboring gene STARR-positive B cell enhancer ABC_E4990 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:14996167-14996320 Neighboring gene predicted gene, 35149 Neighboring gene STARR-seq mESC enhancer starr_20800 Neighboring gene predicted gene, 35340 Neighboring gene expressed sequence BB014433

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Kbtbd11 gene expression in adipose tissue increases in response to feeding and affects adipocyte differentiation. Watanabe K, et al. J Diabetes Investig, 2019 Jul. PMID 30582777, Free PMC Article
    2. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
    3. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article
    4. Gene expression analysis of the embryonic subplate. Oeschger FM, et al. Cereb Cortex, 2012 Jun. PMID 21862448, Free PMC Article
    5. Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Wilkinson B, et al. Sci Rep, 2017 Jul 13. PMID 28706196, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kbtbd11 appears to be required for the differentiation of adipocytes in 3T3-L1 cells
      Title: Kbtbd11 gene expression in adipose tissue increases in response to feeding and affects adipocyte differentiation.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    kelch repeat and BTB domain-containing protein 11

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029116.2 → NP_083392.1  kelch repeat and BTB domain-containing protein 11

      See identical proteins and their annotated locations for NP_083392.1

      Status: VALIDATED

      Source sequence(s)
      AC124604, AK013531, BC080858, BY712628, CX207757
      Consensus CDS
      CCDS52493.1
      UniProtKB/Swiss-Prot
      A3KME3, Q8BNW9
      Related
      ENSMUSP00000068321.6, ENSMUST00000069399.7
      Conserved Domains (5) summary
      PHA03098
      Location:354 → 491
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:356 → 404
      Kelch; KELCH repeat [structural motif]
      cl38908
      Location:142 → 246
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      NF033913
      Location:16 → 108
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
      cl28903
      Location:237 → 313
      BACK; BACK (BTB and C-terminal Kelch) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      15059408..15083333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508915.3 → XP_006508978.1  kelch repeat and BTB domain-containing protein 11 isoform X1

      See identical proteins and their annotated locations for XP_006508978.1

      UniProtKB/Swiss-Prot
      A3KME3, Q8BNW9
      Conserved Domains (5) summary
      PHA03098
      Location:354 → 491
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:356 → 404
      Kelch; KELCH repeat [structural motif]
      cl38908
      Location:142 → 246
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      NF033913
      Location:16 → 108
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
      cl28903
      Location:237 → 313
      BACK; BACK (BTB and C-terminal Kelch) domain

    2. XM_006508916.4 → XP_006508979.1  kelch repeat and BTB domain-containing protein 11 isoform X1

      See identical proteins and their annotated locations for XP_006508979.1

      UniProtKB/Swiss-Prot
      A3KME3, Q8BNW9
      Conserved Domains (5) summary
      PHA03098
      Location:354 → 491
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:356 → 404
      Kelch; KELCH repeat [structural motif]
      cl38908
      Location:142 → 246
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      NF033913
      Location:16 → 108
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
      cl28903
      Location:237 → 313
      BACK; BACK (BTB and C-terminal Kelch) domain

    3. XM_036154344.1 → XP_036010237.1  kelch repeat and BTB domain-containing protein 11 isoform X1

      UniProtKB/Swiss-Prot
      A3KME3, Q8BNW9
      Related
      ENSMUSP00000139292.2, ENSMUST00000183471.2
      Conserved Domains (5) summary
      PHA03098
      Location:354 → 491
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:356 → 404
      Kelch; KELCH repeat [structural motif]
      cl38908
      Location:142 → 246
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      NF033913
      Location:16 → 108
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
      cl28903
      Location:237 → 313
      BACK; BACK (BTB and C-terminal Kelch) domain

    4. XM_036154345.1 → XP_036010238.1  kelch repeat and BTB domain-containing protein 11 isoform X1

      UniProtKB/Swiss-Prot
      A3KME3, Q8BNW9
      Conserved Domains (5) summary
      PHA03098
      Location:354 → 491
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:356 → 404
      Kelch; KELCH repeat [structural motif]
      cl38908
      Location:142 → 246
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      NF033913
      Location:16 → 108
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
      cl28903
      Location:237 → 313
      BACK; BACK (BTB and C-terminal Kelch) domain

    RNA

    1. XR_870083.3 RNA Sequence

    2. XR_870084.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BNW9.3 GenPept UniProtKB/Swiss-Prot:Q8BNW9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous