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SEC16A SEC16 homolog A, endoplasmic reticulum export factor [ Homo sapiens (human) ]

Gene ID: 9919, updated on 27-Aug-2024

Summary

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Official Symbol
SEC16Aprovided by HGNC
Official Full Name
SEC16 homolog A, endoplasmic reticulum export factorprovided by HGNC
Primary source
HGNC:HGNC:29006
See related
Ensembl:ENSG00000148396 MIM:612854; AllianceGenome:HGNC:29006
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p250; SEC16L; KIAA0310
Summary
This gene encodes a protein that forms part of the Sec16 complex. This protein has a role in protein transport from the endoplasmic reticulum (ER) to the Golgi and mediates COPII vesicle formation at the transitional ER. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Feb 2013]
Expression
Ubiquitous expression in stomach (RPKM 11.7), bone marrow (RPKM 11.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
9q34.3
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (136440105..136484740, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (148669197..148713859, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139334557..139378235, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29308 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29309 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:139310410-139311609 Neighboring gene peptidase, mitochondrial processing subunit alpha Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139330456-139330964 Neighboring gene hESC enhancers GRCh37_chr9:139332501-139333134 to GRCh37_chr9:139333770-139334403 Neighboring gene inositol polyphosphate-5-phosphatase E Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:139342099-139343298 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:139376640-139377385 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139378131-139378875 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20524 Neighboring gene chromosome 9 putative open reading frame 163 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:139392592-139393791 Neighboring gene notch receptor 1 Neighboring gene uncharacterized LOC124902310 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139420763-139421634 Neighboring gene microRNA 4673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20525 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139433302-139433969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139434130-139434814 Neighboring gene Sharpr-MPRA regulatory region 6589 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139436183-139436865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20526 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20527 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20528 Neighboring gene microRNA 4674

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Regulation of Sec16 levels and dynamics links proliferation and secretion. Tillmann KD, et al. J Cell Sci, 2015 Feb 15. PMID 25526736
  2. Next generation exome sequencing of paediatric inflammatory bowel disease patients identifies rare and novel variants in candidate genes. Christodoulou K, et al. Gut, 2013 Jul. PMID 22543157, Free PMC Article
  3. Are breast cancers driven by fusion genes? Edwards PA, et al. Breast Cancer Res, 2012 Mar 16. PMID 22424054, Free PMC Article
  4. Sec12 binds to Sec16 at transitional ER sites. Montegna EA, et al. PLoS One, 2012. PMID 22347445, Free PMC Article
  5. Sec16A defines the site for vesicle budding from the endoplasmic reticulum on exit from mitosis. Hughes H, et al. J Cell Sci, 2010 Dec 1. PMID 21045114, Free PMC Article

See all (176) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nbeal2 interacts with Dock7, Sec16a, and Vac14.
    Title: Nbeal2 interacts with Dock7, Sec16a, and Vac14.
  2. these findings highlight a novel function of Sec16A as an essential mediator of endoplasmic reticulum stress-associated unconventional secretion.
    Title: Sec16A is critical for both conventional and unconventional secretion of CFTR.
  3. Sec16A also stabilized the interacting ubiquitin ligase RNF152, which localizes to the lysosome and has structural similarity with RNF183
    Title: Sec16A, a key protein in COPII vesicle formation, regulates the stability and localization of the novel ubiquitin ligase RNF183.
  4. Mammalian endoplasmic reticulum exit sites are organized by TANGO1 acting as a scaffold, in cooperation with Sec16 for efficient secretion.
    Title: TANGO1 recruits Sec16 to coordinately organize ER exit sites for efficient secretion.
  5. Results suggest that it is the presence of rare syntenic SEC16A and MAMDC4 deletions that increases susceptibility to axial spondyloarthritis in family members who carry the HLA-B*27 allele.
    Title: Private rare deletions in SEC16A and MAMDC4 may represent novel pathogenic variants in familial axial spondyloarthritis.
  6. growth factors modulate Sec16 protein levels and dynamics. Sec16 acts as part of a coherent feed-forward loop, which integrates secretion and growth factor signaling.
    Title: Regulation of Sec16 levels and dynamics links proliferation and secretion.
  7. LRRK2 regulates the anterograde endoplasmic reticulum (ER)-Golgi transport through anchoring Sec16A at the endoplasmic reticulum exit sites (ERES).
    Title: Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export.
  8. Data show that knockdown of Sec16B but not Sec16A by RNAi affected the morphology of peroxisomes, inhibited the transport of Pex16 from the ER to peroxisomes, and suppressed expression of Pex3.
    Title: Sec16B is involved in the endoplasmic reticulum export of the peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in mammalian cells.
  9. Sec16A remains associated with endoplasmic reticulum exit sites throughout mitosis.
    Title: Sec16A defines the site for vesicle budding from the endoplasmic reticulum on exit from mitosis.
  10. These data are consistent with a model where Sec16 acts as a platform for COPII assembly at endoplasmic reticulum exit sites.
    Title: Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ26737, KIAA0310

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in COPII vesicle coating IEA
Inferred from Electronic Annotation
more info
  
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to plasma membrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein exit from endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to endoplasmic reticulum exit site IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of COPII vesicle coating IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in substantia nigra development HEP PubMed 
Component Evidence Code Pubs
is_active_in ER to Golgi transport vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum exit site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in organelle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein transport protein Sec16A
Names
protein SEC16 homolog A
NP_001263347.1
NP_055681.1
XP_005266191.1
XP_011517549.1
XP_011517551.1
XP_011517554.1
XP_011517558.1
XP_011517559.1
XP_011517561.1
XP_011517562.1
XP_011517564.1
XP_011517565.1
XP_047280181.1
XP_047280182.1
XP_047280183.1
XP_047280184.1
XP_047280185.1
XP_047280186.1
XP_047280187.1
XP_047280188.1
XP_047280189.1
XP_047280190.1
XP_047280191.1
XP_047280192.1
XP_047280193.1
XP_047280194.1
XP_047280195.1
XP_047280196.1
XP_047280197.1
XP_047280198.1
XP_047280199.1
XP_047280200.1
XP_047280201.1
XP_047280202.1
XP_047280203.1
XP_047280204.1
XP_047280205.1
XP_047280206.1
XP_047280207.1
XP_047280208.1
XP_047280209.1
XP_047280210.1
XP_047280211.1
XP_047280212.1
XP_047280213.1
XP_047280214.1
XP_047280215.1
XP_047280216.1
XP_047280217.1
XP_047280218.1
XP_047280219.1
XP_047280220.1
XP_054220341.1
XP_054220342.1
XP_054220343.1
XP_054220344.1
XP_054220345.1
XP_054220346.1
XP_054220347.1
XP_054220348.1
XP_054220349.1
XP_054220350.1
XP_054220351.1
XP_054220352.1
XP_054220353.1
XP_054220354.1
XP_054220355.1
XP_054220356.1
XP_054220357.1
XP_054220358.1
XP_054220359.1
XP_054220360.1
XP_054220361.1
XP_054220362.1
XP_054220363.1
XP_054220364.1
XP_054220365.1
XP_054220366.1
XP_054220367.1
XP_054220368.1
XP_054220369.1
XP_054220370.1
XP_054220371.1
XP_054220372.1
XP_054220373.1
XP_054220374.1
XP_054220375.1
XP_054220376.1
XP_054220377.1
XP_054220378.1
XP_054220379.1
XP_054220380.1
XP_054220381.1
XP_054220382.1
XP_054220383.1
XP_054220384.1
XP_054220385.1
XP_054220386.1
XP_054220387.1
XP_054220388.1
XP_054220389.1
XP_054220390.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276418.2 → NP_001263347.1  protein transport protein Sec16A isoform 2

    See identical proteins and their annotated locations for NP_001263347.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks two alternate in-frame exons in the coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AB002308, AB593115, AL592301, BC070488
    Consensus CDS
    CCDS75936.1
    UniProtKB/TrEMBL
    A0A3F2YNX0, F1T0I1
    Related
    ENSP00000290037.7, ENST00000290037.10
    Conserved Domains (1) summary
    cd09233
    Location:1497 → 1859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

  2. NM_014866.2 → NP_055681.1  protein transport protein Sec16A isoform 1

    See identical proteins and their annotated locations for NP_055681.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB002308, BM975558
    Consensus CDS
    CCDS55351.1
    UniProtKB/Swiss-Prot
    A1YCA4, J3KNL6, O15027, Q4G0D7, Q5SXP0, Q5SXP1, Q8N347, Q96HP1
    UniProtKB/TrEMBL
    A0A3F2YNZ0
    Related
    ENSP00000508822.1, ENST00000684901.1
    Conserved Domains (2) summary
    cd09233
    Location:1497 → 1859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    cl26464
    Location:4 → 298
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    136440105..136484740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424252.1 → XP_047280208.1  protein transport protein Sec16A isoform X27

    UniProtKB/TrEMBL
    A0A3F2YNX0

  2. XM_047424250.1 → XP_047280206.1  protein transport protein Sec16A isoform X26

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  3. XM_047424248.1 → XP_047280204.1  protein transport protein Sec16A isoform X24

    UniProtKB/TrEMBL
    A0A8I5KPG1, A4QN19, E7ESY3

  4. XM_047424244.1 → XP_047280200.1  protein transport protein Sec16A isoform X21

    UniProtKB/TrEMBL
    A4QN19, E7ESY3

  5. XM_047424246.1 → XP_047280202.1  protein transport protein Sec16A isoform X23

    UniProtKB/TrEMBL
    A4QN19, E7ESY3

  6. XM_047424249.1 → XP_047280205.1  protein transport protein Sec16A isoform X25

    UniProtKB/TrEMBL
    A0A3F2YNX0

  7. XM_047424245.1 → XP_047280201.1  protein transport protein Sec16A isoform X22

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  8. XM_047424243.1 → XP_047280199.1  protein transport protein Sec16A isoform X20

    UniProtKB/TrEMBL
    A4QN19, E7ESY3

  9. XM_047424242.1 → XP_047280198.1  protein transport protein Sec16A isoform X19

    UniProtKB/TrEMBL
    A4QN19, E7ESY3

  10. XM_047424240.1 → XP_047280196.1  protein transport protein Sec16A isoform X17

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  11. XM_047424236.1 → XP_047280192.1  protein transport protein Sec16A isoform X13

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  12. XM_047424239.1 → XP_047280195.1  protein transport protein Sec16A isoform X16

    UniProtKB/TrEMBL
    A0A3F2YNX0

  13. XM_047424241.1 → XP_047280197.1  protein transport protein Sec16A isoform X18

    UniProtKB/TrEMBL
    A0A3F2YNX0

  14. XM_047424235.1 → XP_047280191.1  protein transport protein Sec16A isoform X12

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  15. XM_047424233.1 → XP_047280189.1  protein transport protein Sec16A isoform X10

    UniProtKB/TrEMBL
    A0A3F2YNX0

  16. XM_047424237.1 → XP_047280193.1  protein transport protein Sec16A isoform X14

    UniProtKB/TrEMBL
    A0A3F2YNX0

  17. XM_047424229.1 → XP_047280185.1  protein transport protein Sec16A isoform X6

    UniProtKB/Swiss-Prot
    A1YCA4, J3KNL6, O15027, Q4G0D7, Q5SXP0, Q5SXP1, Q8N347, Q96HP1
    UniProtKB/TrEMBL
    A0A3F2YNZ0

  18. XM_047424232.1 → XP_047280188.1  protein transport protein Sec16A isoform X9

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  19. XM_047424225.1 → XP_047280181.1  protein transport protein Sec16A isoform X2

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  20. XM_047424227.1 → XP_047280183.1  protein transport protein Sec16A isoform X4

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  21. XM_047424234.1 → XP_047280190.1  protein transport protein Sec16A isoform X11

    UniProtKB/TrEMBL
    A0A3F2YNX0, F1T0I1

  22. XM_047424238.1 → XP_047280194.1  protein transport protein Sec16A isoform X15

    UniProtKB/TrEMBL
    A0A3F2YNX0

  23. XM_047424231.1 → XP_047280187.1  protein transport protein Sec16A isoform X8

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  24. XM_047424228.1 → XP_047280184.1  protein transport protein Sec16A isoform X5

    UniProtKB/TrEMBL
    A0A3F2YNX0

  25. XM_047424230.1 → XP_047280186.1  protein transport protein Sec16A isoform X7

    UniProtKB/TrEMBL
    A0A3F2YNX0

  26. XM_011519260.3 → XP_011517562.1  protein transport protein Sec16A isoform X1

    See identical proteins and their annotated locations for XP_011517562.1

    UniProtKB/TrEMBL
    A0A3F2YNZ0
    Conserved Domains (1) summary
    cd09233
    Location:1497 → 1859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

  27. XM_047424226.1 → XP_047280182.1  protein transport protein Sec16A isoform X3

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  28. XM_011519247.3 → XP_011517549.1  protein transport protein Sec16A isoform X1

    See identical proteins and their annotated locations for XP_011517549.1

    UniProtKB/TrEMBL
    A0A3F2YNZ0
    Conserved Domains (1) summary
    cd09233
    Location:1497 → 1859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

  29. XM_047424264.1 → XP_047280220.1  protein transport protein Sec16A isoform X31

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  30. XM_047424261.1 → XP_047280217.1  protein transport protein Sec16A isoform X29

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  31. XM_047424263.1 → XP_047280219.1  protein transport protein Sec16A isoform X27

    UniProtKB/TrEMBL
    A0A3F2YNX0

  32. XM_047424260.1 → XP_047280216.1  protein transport protein Sec16A isoform X26

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  33. XM_011519263.2 → XP_011517565.1  protein transport protein Sec16A isoform X24

    UniProtKB/TrEMBL
    A0A8I5KPG1, A4QN19, E7ESY3
    Related
    ENSP00000508778.1, ENST00000690691.1
    Conserved Domains (1) summary
    cd09233
    Location:1260 → 1622
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

  34. XM_047424256.1 → XP_047280212.1  protein transport protein Sec16A isoform X21

    UniProtKB/TrEMBL
    A4QN19, E7ESY3

  35. XM_047424258.1 → XP_047280214.1  protein transport protein Sec16A isoform X23

    UniProtKB/TrEMBL
    A4QN19, E7ESY3

  36. XM_047424262.1 → XP_047280218.1  protein transport protein Sec16A isoform X30

    UniProtKB/TrEMBL
    A0A3F2YNX0

  37. XM_047424254.1 → XP_047280210.1  protein transport protein Sec16A isoform X28

    UniProtKB/TrEMBL
    A4QN19, E7ESY3

  38. XM_047424259.1 → XP_047280215.1  protein transport protein Sec16A isoform X25

    UniProtKB/TrEMBL
    A0A3F2YNX0

  39. XM_047424257.1 → XP_047280213.1  protein transport protein Sec16A isoform X22

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  40. XM_047424255.1 → XP_047280211.1  protein transport protein Sec16A isoform X20

    UniProtKB/TrEMBL
    A4QN19, E7ESY3

  41. XM_011519262.2 → XP_011517564.1  protein transport protein Sec16A isoform X19

    UniProtKB/TrEMBL
    A4QN19, E7ESY3
    Conserved Domains (2) summary
    cd09233
    Location:1260 → 1622
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    PHA03247
    Location:4 → 298
    PHA03247; large tegument protein UL36; Provisional

  42. XM_047424253.1 → XP_047280209.1  protein transport protein Sec16A isoform X17

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  43. XM_011519259.3 → XP_011517561.1  protein transport protein Sec16A isoform X16

    UniProtKB/TrEMBL
    A0A3F2YNX0
    Related
    ENSP00000360771.4, ENST00000371706.8
    Conserved Domains (1) summary
    cd09233
    Location:1497 → 1859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

  44. XM_011519257.2 → XP_011517559.1  protein transport protein Sec16A isoform X12

    UniProtKB/TrEMBL
    A0A3F2YNZ0
    Related
    ENSP00000387583.2, ENST00000431893.3
    Conserved Domains (1) summary
    cd09233
    Location:1497 → 1859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

  45. XM_047424251.1 → XP_047280207.1  protein transport protein Sec16A isoform X14

    UniProtKB/TrEMBL
    A0A3F2YNX0

  46. XM_011519252.2 → XP_011517554.1  protein transport protein Sec16A isoform X6

    See identical proteins and their annotated locations for XP_011517554.1

    UniProtKB/Swiss-Prot
    A1YCA4, J3KNL6, O15027, Q4G0D7, Q5SXP0, Q5SXP1, Q8N347, Q96HP1
    UniProtKB/TrEMBL
    A0A3F2YNZ0
    Related
    ENSP00000325827.7, ENST00000313050.11
    Conserved Domains (2) summary
    cd09233
    Location:1497 → 1859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    cl26464
    Location:4 → 298
    Atrophin-1; Atrophin-1 family

  47. XM_047424247.1 → XP_047280203.1  protein transport protein Sec16A isoform X9

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  48. XM_011519249.2 → XP_011517551.1  protein transport protein Sec16A isoform X2

    UniProtKB/TrEMBL
    A0A3F2YNZ0
    Conserved Domains (1) summary
    cd09233
    Location:1497 → 1859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

  49. XM_011519256.2 → XP_011517558.1  protein transport protein Sec16A isoform X11

    See identical proteins and their annotated locations for XP_011517558.1

    UniProtKB/TrEMBL
    A0A3F2YNX0, F1T0I1
    Conserved Domains (1) summary
    cd09233
    Location:1497 → 1859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

  50. XM_005266134.3 → XP_005266191.1  protein transport protein Sec16A isoform X1

    See identical proteins and their annotated locations for XP_005266191.1

    UniProtKB/TrEMBL
    A0A3F2YNZ0
    Conserved Domains (1) summary
    cd09233
    Location:1497 → 1859
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    148669197..148713859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364400.1 → XP_054220375.1  protein transport protein Sec16A isoform X57

    UniProtKB/TrEMBL
    A0A3F2YNX0

  2. XM_054364395.1 → XP_054220370.1  protein transport protein Sec16A isoform X56

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  3. XM_054364393.1 → XP_054220368.1  protein transport protein Sec16A isoform X54

    UniProtKB/TrEMBL
    A0A3F2YNX0

  4. XM_054364387.1 → XP_054220362.1  protein transport protein Sec16A isoform X51

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  5. XM_054364390.1 → XP_054220365.1  protein transport protein Sec16A isoform X53

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  6. XM_054364394.1 → XP_054220369.1  protein transport protein Sec16A isoform X55

    UniProtKB/TrEMBL
    A0A3F2YNX0

  7. XM_054364388.1 → XP_054220363.1  protein transport protein Sec16A isoform X52

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  8. XM_054364386.1 → XP_054220361.1  protein transport protein Sec16A isoform X50

    UniProtKB/TrEMBL
    A0A3F2YNX0

  9. XM_054364384.1 → XP_054220359.1  protein transport protein Sec16A isoform X49

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  10. XM_054364381.1 → XP_054220356.1  protein transport protein Sec16A isoform X47

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  11. XM_054364377.1 → XP_054220352.1  protein transport protein Sec16A isoform X43

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  12. XM_054364380.1 → XP_054220355.1  protein transport protein Sec16A isoform X46

    UniProtKB/TrEMBL
    A0A3F2YNX0

  13. XM_054364382.1 → XP_054220357.1  protein transport protein Sec16A isoform X48

    UniProtKB/TrEMBL
    A0A3F2YNX0

  14. XM_054364376.1 → XP_054220351.1  protein transport protein Sec16A isoform X42

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  15. XM_054364374.1 → XP_054220349.1  protein transport protein Sec16A isoform X40

    UniProtKB/TrEMBL
    A0A3F2YNX0

  16. XM_054364378.1 → XP_054220353.1  protein transport protein Sec16A isoform X44

    UniProtKB/TrEMBL
    A0A3F2YNX0

  17. XM_054364371.1 → XP_054220346.1  protein transport protein Sec16A isoform X37

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  18. XM_054364373.1 → XP_054220348.1  protein transport protein Sec16A isoform X39

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  19. XM_054364367.1 → XP_054220342.1  protein transport protein Sec16A isoform X33

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  20. XM_054364369.1 → XP_054220344.1  protein transport protein Sec16A isoform X35

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  21. XM_054364375.1 → XP_054220350.1  protein transport protein Sec16A isoform X41

    UniProtKB/TrEMBL
    A0A3F2YNX0

  22. XM_054364379.1 → XP_054220354.1  protein transport protein Sec16A isoform X45

    UniProtKB/TrEMBL
    A0A3F2YNX0

  23. XM_054364370.1 → XP_054220345.1  protein transport protein Sec16A isoform X36

    UniProtKB/TrEMBL
    A0A3F2YNX0

  24. XM_054364372.1 → XP_054220347.1  protein transport protein Sec16A isoform X38

    UniProtKB/TrEMBL
    A0A3F2YNX0

  25. XM_054364366.1 → XP_054220341.1  protein transport protein Sec16A isoform X32

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  26. XM_054364368.1 → XP_054220343.1  protein transport protein Sec16A isoform X34

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  27. XM_054364389.1 → XP_054220364.1  protein transport protein Sec16A isoform X1

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  28. XM_054364401.1 → XP_054220376.1  protein transport protein Sec16A isoform X16

    UniProtKB/TrEMBL
    A0A3F2YNX0

  29. XM_054364396.1 → XP_054220371.1  protein transport protein Sec16A isoform X11

    UniProtKB/TrEMBL
    A0A3F2YNX0, F1T0I1

  30. XM_054364402.1 → XP_054220377.1  protein transport protein Sec16A isoform X17

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  31. XM_054364399.1 → XP_054220374.1  protein transport protein Sec16A isoform X13

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  32. XM_054364398.1 → XP_054220373.1  protein transport protein Sec16A isoform X12

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  33. XM_054364397.1 → XP_054220372.1  protein transport protein Sec16A isoform X14

    UniProtKB/TrEMBL
    A0A3F2YNX0

  34. XM_054364391.1 → XP_054220366.1  protein transport protein Sec16A isoform X6

    UniProtKB/Swiss-Prot
    A1YCA4, J3KNL6, O15027, Q4G0D7, Q5SXP0, Q5SXP1, Q8N347, Q96HP1
    UniProtKB/TrEMBL
    A0A3F2YNZ0

  35. XM_054364392.1 → XP_054220367.1  protein transport protein Sec16A isoform X9

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  36. XM_054364385.1 → XP_054220360.1  protein transport protein Sec16A isoform X2

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  37. XM_054364383.1 → XP_054220358.1  protein transport protein Sec16A isoform X1

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  38. XM_054364406.1 → XP_054220381.1  protein transport protein Sec16A isoform X21

    UniProtKB/TrEMBL
    A4QN19, E7ESY3

  39. XM_054364411.1 → XP_054220386.1  protein transport protein Sec16A isoform X26

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  40. XM_054364409.1 → XP_054220384.1  protein transport protein Sec16A isoform X24

    UniProtKB/TrEMBL
    A0A8I5KPG1, A4QN19, E7ESY3

  41. XM_054364415.1 → XP_054220390.1  protein transport protein Sec16A isoform X31

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  42. XM_054364412.1 → XP_054220387.1  protein transport protein Sec16A isoform X29

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  43. XM_054364414.1 → XP_054220389.1  protein transport protein Sec16A isoform X27

    UniProtKB/TrEMBL
    A0A3F2YNX0

  44. XM_054364408.1 → XP_054220383.1  protein transport protein Sec16A isoform X23

    UniProtKB/TrEMBL
    A4QN19, E7ESY3

  45. XM_054364413.1 → XP_054220388.1  protein transport protein Sec16A isoform X30

    UniProtKB/TrEMBL
    A0A3F2YNX0

  46. XM_054364404.1 → XP_054220379.1  protein transport protein Sec16A isoform X28

    UniProtKB/TrEMBL
    A4QN19, E7ESY3

  47. XM_054364410.1 → XP_054220385.1  protein transport protein Sec16A isoform X25

    UniProtKB/TrEMBL
    A0A3F2YNX0

  48. XM_054364407.1 → XP_054220382.1  protein transport protein Sec16A isoform X22

    UniProtKB/TrEMBL
    A0A3F2YNZ0

  49. XM_054364405.1 → XP_054220380.1  protein transport protein Sec16A isoform X20

    UniProtKB/TrEMBL
    A4QN19, E7ESY3

  50. XM_054364403.1 → XP_054220378.1  protein transport protein Sec16A isoform X19

    UniProtKB/TrEMBL
    A4QN19, E7ESY3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15027.4 GenPept UniProtKB/Swiss-Prot:O15027

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