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PLPPR4 phospholipid phosphatase related 4 [ Homo sapiens (human) ]

Gene ID: 9890, updated on 22-May-2022

Summary

Official Symbol
PLPPR4provided by HGNC
Official Full Name
phospholipid phosphatase related 4provided by HGNC
Primary source
HGNC:HGNC:23496
See related
Ensembl:ENSG00000117600 MIM:607813; AllianceGenome:HGNC:23496
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPR4; PHP1; PRG1; LPPR4; PRG-1
Summary
The protein encoded by this gene belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Expression
Biased expression in brain (RPKM 35.4), testis (RPKM 3.7) and 2 other tissues See more
Orthologs
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Genomic context

See PLPPR4 in Genome Data Viewer
Location:
1p21.3-p21.2
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (99262924..99309584)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (99112833..99157921)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (99730048..99775140)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phospholipid phosphatase related 5 Neighboring gene PLPPR5 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 9288 Neighboring gene uncharacterized LOC107985093 Neighboring gene CXXC motif containing zinc binding protein-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0455

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lipid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT enables lysophosphatidic acid phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidate phosphatase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
acts_upstream_of G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inner ear development IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid import into cell ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in phospholipid dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of synaptic transmission, glutamatergic ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
phospholipid phosphatase-related protein type 4
Names
2-lysophosphatidate phosphatase PLPPR4
brain-specific phosphatidic acid phosphatase-like protein 1
inactive 2-lysophosphatidate phosphatase PLPPR4
lipid phosphate phosphatase-related protein type 4
plasticity related gene 1
plasticity-related gene 1 protein
NP_001159724.2
NP_055654.3
XP_011540800.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166252.2NP_001159724.2  phospholipid phosphatase-related protein type 4 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon in the 3' region, as compared to variant 1. The resulting isoform (2) is shorter and lacks an internal segment in the C-terminal region, as compared to isoform 1.
    Source sequence(s)
    AL136147, AL139425
    Consensus CDS
    CCDS53347.1
    Related
    ENSP00000394913.2, ENST00000457765.6
    Conserved Domains (1) summary
    cl00474
    Location:126219
    PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...
  2. NM_014839.5NP_055654.3  phospholipid phosphatase-related protein type 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL136147, AL139425
    Consensus CDS
    CCDS757.1
    Related
    ENSP00000359204.4, ENST00000370185.9
    Conserved Domains (1) summary
    cd03384
    Location:126275
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    99262924..99309584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542498.3XP_011540800.1  phospholipid phosphatase-related protein type 4 isoform X1

    See identical proteins and their annotated locations for XP_011540800.1

    Conserved Domains (1) summary
    cd03384
    Location:65214
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    99112833..99157921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)