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PLPPR4 phospholipid phosphatase related 4 [ Homo sapiens (human) ]

Gene ID: 9890, updated on 22-Aug-2020

Summary

Official Symbol
PLPPR4provided by HGNC
Official Full Name
phospholipid phosphatase related 4provided by HGNC
Primary source
HGNC:HGNC:23496
See related
Ensembl:ENSG00000117600 MIM:607813
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPR4; PHP1; PRG1; LPPR4; PRG-1
Summary
The protein encoded by this gene belongs to the lipid phosphate phosphatase (LPP) family. LPPs catalyze the dephosphorylation of a number of bioactive lipid mediators that regulate a variety of cell functions. This protein is specifically expressed in neurons. It is located in the membranes of outgrowing axons and has been shown to be important for axonal outgrowth during development and regenerative sprouting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Expression
Biased expression in brain (RPKM 35.4), testis (RPKM 3.7) and 2 other tissues See more
Orthologs

Genomic context

See PLPPR4 in Genome Data Viewer
Location:
1p21.3-p21.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (99262956..99309584)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (99729848..99775140)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene sorting nexin 7 Neighboring gene phospholipid phosphatase related 5 Neighboring gene uncharacterized LOC100129620 Neighboring gene uncharacterized LOC107985093 Neighboring gene UPF0587 protein C1orf123 homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0455

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inner ear development IEA
Inferred from Electronic Annotation
more info
 
phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
phospholipid phosphatase-related protein type 4
Names
brain-specific phosphatidic acid phosphatase-like protein 1
lipid phosphate phosphatase-related protein type 4
plasticity related gene 1
plasticity-related gene 1 protein
NP_001159724.1
NP_055654.3
XP_011540800.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166252.1NP_001159724.1  phospholipid phosphatase-related protein type 4 isoform 2

    See identical proteins and their annotated locations for NP_001159724.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon in the 3' region, as compared to variant 1. The resulting isoform (2) is shorter and lacks an internal segment in the C-terminal region, as compared to isoform 1.
    Source sequence(s)
    AB007924, AF541281, AL834390
    Consensus CDS
    CCDS53347.1
    UniProtKB/Swiss-Prot
    Q7Z2D5
    Related
    ENSP00000394913.1, ENST00000457765.5
    Conserved Domains (1) summary
    cl00474
    Location:174267
    PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...
  2. NM_014839.5NP_055654.3  phospholipid phosphatase-related protein type 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL136147, AL139425
    Consensus CDS
    CCDS757.1
    Related
    ENSP00000359204.3, ENST00000370185.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    99262956..99309584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542498.2XP_011540800.1  phospholipid phosphatase-related protein type 4 isoform X1

    See identical proteins and their annotated locations for XP_011540800.1

    Related
    ENSP00000359203.1, ENST00000370184.1
    Conserved Domains (1) summary
    cd03384
    Location:65214
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
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