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ZBED4 zinc finger BED-type containing 4 [ Homo sapiens (human) ]

Gene ID: 9889, updated on 6-Sep-2022

Summary

Official Symbol
ZBED4provided by HGNC
Official Full Name
zinc finger BED-type containing 4provided by HGNC
Primary source
HGNC:HGNC:20721
See related
Ensembl:ENSG00000100426 MIM:612552; AllianceGenome:HGNC:20721
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables identical protein binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 4.8), colon (RPKM 4.3) and 25 other tissues See more
Orthologs
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Genomic context

See ZBED4 in Genome Data Viewer
Location:
22q13.33
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (49852850..49890080)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (50358137..50394562)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50247492..50283728)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377205 Neighboring gene basic proline-rich protein-like Neighboring gene sterile alpha motif domain-containing protein 1-like Neighboring gene uncharacterized LOC124905147 Neighboring gene ALG12 alpha-1,6-mannosyltransferase Neighboring gene cysteine rich with EGF like domains 2 Neighboring gene microRNA 6821 Neighboring gene Pim-3 proto-oncogene, serine/threonine kinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription cis-regulatory region binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor inner segment IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger BED domain-containing protein 4
Names
zinc finger, BED domain containing 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014838.3NP_055653.2  zinc finger BED domain-containing protein 4

    See identical proteins and their annotated locations for NP_055653.2

    Status: VALIDATED

    Source sequence(s)
    AA809789, AL117328, DB457646
    Consensus CDS
    CCDS33677.1
    UniProtKB/Swiss-Prot
    O75132, Q9UGG8
    Related
    ENSP00000216268.4, ENST00000216268.6
    Conserved Domains (2) summary
    pfam02892
    Location:118166
    zf-BED; BED zinc finger
    pfam05699
    Location:10881164
    Dimer_Tnp_hAT; hAT family C-terminal dimerisation region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    49852850..49890080
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441685.1XP_047297641.1  zinc finger BED domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9UGG8
  2. XM_047441686.1XP_047297642.1  zinc finger BED domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9UGG8
  3. XM_047441684.1XP_047297640.1  zinc finger BED domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9UGG8
  4. XM_024452312.2XP_024308080.1  zinc finger BED domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9UGG8
    Conserved Domains (2) summary
    pfam02892
    Location:118166
    zf-BED; BED zinc finger
    pfam05699
    Location:10881164
    Dimer_Tnp_hAT; hAT family C-terminal dimerisation region

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    50358137..50394562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)