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Cdc123 cell division cycle 123 [ Mus musculus (house mouse) ]

Gene ID: 98828, updated on 26-Sep-2022

Summary

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Official Symbol
Cdc123provided by MGI
Official Full Name
cell division cycle 123provided by MGI
Primary source
MGI:MGI:2138811
See related
Ensembl:ENSMUSG00000039128 AllianceGenome:MGI:2138811
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G431001I09Rik
Summary
Predicted to act upstream of or within cell division. Predicted to be active in cytoplasm. Orthologous to human CDC123 (cell division cycle 123). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 25.7), CNS E11.5 (RPKM 25.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cdc123 in Genome Data Viewer
Location:
2; 2 A1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (5799105..5849988, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (5794294..5845177, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin-dependent protein kinase ID Neighboring gene ribosomal protein L19 pseudogene Neighboring gene predicted gene, 29857 Neighboring gene predicted gene, 29984 Neighboring gene nudix hydrolase 5 Neighboring gene predicted gene 13199 Neighboring gene Sec61, alpha subunit 2 (S. cerevisiae)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (21) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cell division cycle protein 123 homolog
Names
cell division cycle 123 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356501.1 → NP_001343430.1  cell division cycle protein 123 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL928924
    Conserved Domains (1) summary
    pfam07065
    Location:14 → 303
    D123; D123

  2. NM_001356502.1 → NP_001343431.1  cell division cycle protein 123 homolog isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL928924
    Conserved Domains (1) summary
    pfam07065
    Location:14 → 273
    D123; D123

  3. NM_001356503.1 → NP_001343432.1  cell division cycle protein 123 homolog isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK161246, AL928924
    Conserved Domains (1) summary
    pfam07065
    Location:14 → 167
    D123; D123

  4. NM_001356504.1 → NP_001343433.1  cell division cycle protein 123 homolog isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL928924
    Conserved Domains (1) summary
    pfam07065
    Location:14 → 156
    D123; D123

  5. NM_133837.5 → NP_598598.1  cell division cycle protein 123 homolog isoform 1

    See identical proteins and their annotated locations for NP_598598.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK159208, AL928924
    Consensus CDS
    CCDS15666.1
    UniProtKB/Swiss-Prot
    Q8CII2, Q8VE51
    Related
    ENSMUSP00000043033.4, ENSMUST00000043864.9
    Conserved Domains (1) summary
    pfam07065
    Location:14 → 314
    D123; D123

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    5799105..5849988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252263.2 → XP_030108123.1  cell division cycle protein 123 homolog isoform X1

    Conserved Domains (1) summary
    pfam07065
    Location:14 → 262
    D123
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CII2.2 GenPept UniProtKB/Swiss-Prot:Q8CII2

Gene LinkOut

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