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Cdc123 cell division cycle 123 [ Mus musculus (house mouse) ]

Gene ID: 98828, updated on 3-May-2025
Official Symbol
Cdc123provided by MGI
Official Full Name
cell division cycle 123provided by MGI
Primary source
MGI:MGI:2138811
See related
Ensembl:ENSMUSG00000039128 AllianceGenome:MGI:2138811
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G431001I09Rik
Summary
Predicted to enable ATP binding activity; magnesium ion binding activity; and protein folding chaperone. Predicted to be involved in eukaryotic translation initiation factor 2 complex assembly. Predicted to be active in cytoplasm. Orthologous to human CDC123 (cell division cycle 123). [provided by Alliance of Genome Resources, May 2025]
Expression
Ubiquitous expression in liver E14 (RPKM 25.7), CNS E11.5 (RPKM 25.1) and 28 other tissues See more
Orthologs
human all
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See Cdc123 in Genome Data Viewer
Location:
2 A1; 2 3.62 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (5799105..5849988, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (5794294..5845177, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin-dependent protein kinase ID Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:5534743-5534896 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:5572598-5572785 Neighboring gene STARR-seq mESC enhancer starr_03568 Neighboring gene STARR-seq mESC enhancer starr_03570 Neighboring gene STARR-seq mESC enhancer starr_03571 Neighboring gene STARR-positive B cell enhancer mm9_chr2:5661717-5662018 Neighboring gene STARR-seq mESC enhancer starr_03574 Neighboring gene predicted gene, 29857 Neighboring gene STARR-seq mESC enhancer starr_03576 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:5766095-5766344 Neighboring gene predicted gene, 29984 Neighboring gene STARR-seq mESC enhancer starr_03579 Neighboring gene STARR-positive B cell enhancer mm9_chr2:5816293-5816594 Neighboring gene nudix hydrolase 5 Neighboring gene predicted gene 13199 Neighboring gene SEC61 translocon subunit alpha 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein folding chaperone ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in eukaryotic translation initiation factor 2 complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in eukaryotic translation initiation factor 2 complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
translation initiation factor eIF2 assembly protein
Names
cell division cycle 123 homolog
cell division cycle protein 123 homolog

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356501.1 → NP_001343430.1  translation initiation factor eIF2 assembly protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL928924
    Conserved Domains (1) summary
    pfam07065
    Location:14 → 303
    D123; D123

  2. NM_001356502.1 → NP_001343431.1  translation initiation factor eIF2 assembly protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL928924
    Conserved Domains (1) summary
    pfam07065
    Location:14 → 273
    D123; D123

  3. NM_001356503.1 → NP_001343432.1  translation initiation factor eIF2 assembly protein isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK161246, AL928924
    Conserved Domains (1) summary
    pfam07065
    Location:14 → 167
    D123; D123

  4. NM_001356504.1 → NP_001343433.1  translation initiation factor eIF2 assembly protein isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL928924
    Conserved Domains (1) summary
    pfam07065
    Location:14 → 156
    D123; D123

  5. NM_133837.5 → NP_598598.1  translation initiation factor eIF2 assembly protein isoform 1

    See identical proteins and their annotated locations for NP_598598.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK159208, AL928924
    Consensus CDS
    CCDS15666.1
    UniProtKB/Swiss-Prot
    Q3TTR0, Q8CII2, Q8VE51
    Related
    ENSMUSP00000043033.4, ENSMUST00000043864.9
    Conserved Domains (1) summary
    pfam07065
    Location:14 → 314
    D123; D123

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    5799105..5849988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252263.2 → XP_030108123.1  translation initiation factor eIF2 assembly protein isoform X1

    Conserved Domains (1) summary
    pfam07065
    Location:14 → 262
    D123
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CII2.2 GenPept UniProtKB/Swiss-Prot:Q8CII2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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