U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hnrnpf heterogeneous nuclear ribonucleoprotein F [ Mus musculus (house mouse) ]

Gene ID: 98758, updated on 26-Sep-2022

Summary

Official Symbol
Hnrnpfprovided by MGI
Official Full Name
heterogeneous nuclear ribonucleoprotein Fprovided by MGI
Primary source
MGI:MGI:2138741
See related
Ensembl:ENSMUSG00000042079 AllianceGenome:MGI:2138741
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hnrpf; 4833420I20Rik
Summary
Predicted to enable TBP-class protein binding activity and single-stranded RNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in cytosol and nucleus. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in nucleoplasm. Is expressed in branchial arch; central nervous system; and sensory organ. Used to study renal glycosuria. Orthologous to human HNRNPF (heterogeneous nuclear ribonucleoprotein F). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 143.4), liver E14.5 (RPKM 122.6) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Hnrnpf in Genome Data Viewer
Location:
6; 6 F1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (117877301..117902583)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (117900340..117925622)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 239 Neighboring gene predicted gene, 38883 Neighboring gene predicted gene, 38882 Neighboring gene RIKEN cDNA 4933440N22 gene Neighboring gene FXYD domain-containing ion transport regulator 4 Neighboring gene predicted gene, 38884 Neighboring gene Lasp1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC36971, MGC101981

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heterogeneous nuclear ribonucleoprotein F
Names
hnRNP F

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166427.1NP_001159899.1  heterogeneous nuclear ribonucleoprotein F

    See identical proteins and their annotated locations for NP_001159899.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same protein.
    Source sequence(s)
    BC047346, CJ094336, CX218091
    Consensus CDS
    CCDS20467.1
    UniProtKB/Swiss-Prot
    Q8R0E7, Q9Z2X1
    Related
    ENSMUSP00000137632.2, ENSMUST00000180020.8
    Conserved Domains (4) summary
    pfam08080
    Location:255290
    zf-RNPHF; RNPHF zinc finger
    cd12506
    Location:289363
    RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
    cd12729
    Location:1088
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
  2. NM_001166428.1NP_001159900.1  heterogeneous nuclear ribonucleoprotein F

    See identical proteins and their annotated locations for NP_001159900.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same protein.
    Source sequence(s)
    BC047346, BY774552, CA539382, CJ054614, CX218091
    Consensus CDS
    CCDS20467.1
    UniProtKB/Swiss-Prot
    Q8R0E7, Q9Z2X1
    Conserved Domains (4) summary
    pfam08080
    Location:255290
    zf-RNPHF; RNPHF zinc finger
    cd12506
    Location:289363
    RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
    cd12729
    Location:1088
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
  3. NM_001166429.1NP_001159901.1  heterogeneous nuclear ribonucleoprotein F

    See identical proteins and their annotated locations for NP_001159901.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same protein.
    Source sequence(s)
    BC047346, BY774552, CK389060, CX218091
    Consensus CDS
    CCDS20467.1
    UniProtKB/Swiss-Prot
    Q8R0E7, Q9Z2X1
    Conserved Domains (4) summary
    pfam08080
    Location:255290
    zf-RNPHF; RNPHF zinc finger
    cd12506
    Location:289363
    RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
    cd12729
    Location:1088
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
  4. NM_001166430.1NP_001159902.1  heterogeneous nuclear ribonucleoprotein F

    See identical proteins and their annotated locations for NP_001159902.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same protein.
    Source sequence(s)
    AU079872, BC047346, CJ048596, CJ169112, CX218091
    Consensus CDS
    CCDS20467.1
    UniProtKB/Swiss-Prot
    Q8R0E7, Q9Z2X1
    Conserved Domains (4) summary
    pfam08080
    Location:255290
    zf-RNPHF; RNPHF zinc finger
    cd12506
    Location:289363
    RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
    cd12729
    Location:1088
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
  5. NM_001166431.1NP_001159903.1  heterogeneous nuclear ribonucleoprotein F

    See identical proteins and their annotated locations for NP_001159903.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same protein.
    Source sequence(s)
    BC047346, CJ048596, CJ094704, CX218091
    Consensus CDS
    CCDS20467.1
    UniProtKB/Swiss-Prot
    Q8R0E7, Q9Z2X1
    Related
    ENSMUSP00000130023.3, ENSMUST00000163168.9
    Conserved Domains (4) summary
    pfam08080
    Location:255290
    zf-RNPHF; RNPHF zinc finger
    cd12506
    Location:289363
    RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
    cd12729
    Location:1088
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
  6. NM_001166432.1NP_001159904.1  heterogeneous nuclear ribonucleoprotein F

    See identical proteins and their annotated locations for NP_001159904.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same protein.
    Source sequence(s)
    BC047346, CF163622, CX218091
    Consensus CDS
    CCDS20467.1
    UniProtKB/Swiss-Prot
    Q8R0E7, Q9Z2X1
    Related
    ENSMUSP00000126817.2, ENSMUST00000167182.8
    Conserved Domains (4) summary
    pfam08080
    Location:255290
    zf-RNPHF; RNPHF zinc finger
    cd12506
    Location:289363
    RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
    cd12729
    Location:1088
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
  7. NM_133834.2NP_598595.1  heterogeneous nuclear ribonucleoprotein F

    See identical proteins and their annotated locations for NP_598595.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript. Variants 1-7 encode the same protein.
    Source sequence(s)
    AK076478, BC047346, CJ048596, CX218091
    Consensus CDS
    CCDS20467.1
    UniProtKB/Swiss-Prot
    Q8R0E7, Q9Z2X1
    Related
    ENSMUSP00000045048.8, ENSMUST00000035493.14
    Conserved Domains (4) summary
    pfam08080
    Location:255290
    zf-RNPHF; RNPHF zinc finger
    cd12506
    Location:289363
    RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
    cd12729
    Location:1088
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    117877301..117902583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506829.5XP_006506892.1  heterogeneous nuclear ribonucleoprotein F isoform X1

    See identical proteins and their annotated locations for XP_006506892.1

    UniProtKB/Swiss-Prot
    Q8R0E7, Q9Z2X1
    Conserved Domains (4) summary
    pfam08080
    Location:255290
    zf-RNPHF; RNPHF zinc finger
    cd12506
    Location:289363
    RRM3_hnRNPH_CRSF1_like; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H protein family, G-rich sequence factor 1 (GRSF-1) and similar proteins
    cd12729
    Location:1088
    RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
    cd12731
    Location:103192
    RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins