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SPATA2 spermatogenesis associated 2 [ Homo sapiens (human) ]

Gene ID: 9825, updated on 12-Oct-2019

Summary

Official Symbol
SPATA2provided by HGNC
Official Full Name
spermatogenesis associated 2provided by HGNC
Primary source
HGNC:HGNC:14681
See related
Ensembl:ENSG00000158480 MIM:607662
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PD1; tamo; PPP1R145
Expression
Broad expression in testis (RPKM 8.7), brain (RPKM 8.4) and 25 other tissues See more
Orthologs

Genomic context

See SPATA2 in Genome Data Viewer
Location:
20q13.13
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (49903391..49915529, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (48519928..48532080, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 9 member A8 Neighboring gene glyoxylate reductase 1 homolog (Arabidopsis) pseudogene Neighboring gene microRNA 12122 Neighboring gene uncharacterized LOC105372653 Neighboring gene ring finger protein 114

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analysis identifies three psoriasis susceptibility loci.
NHGRI GWA Catalog
Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13167, KIAA0757

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
programmed cell death IEA
Inferred from Electronic Annotation
more info
 
protein K63-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein linear deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
regulation of necroptotic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
spermatogenesis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
fibrillar center IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
spermatogenesis-associated protein 2
Names
protein phosphatase 1, regulatory subunit 145
spermatogenesis associated PD1
spermatogenesis-associated protein PD1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135773.1NP_001129245.1  spermatogenesis-associated protein 2

    See identical proteins and their annotated locations for NP_001129245.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1.
    Source sequence(s)
    AK289644, AL031685, BC009481, N62318
    Consensus CDS
    CCDS13422.1
    UniProtKB/Swiss-Prot
    Q9UM82
    UniProtKB/TrEMBL
    A8K0S9
    Related
    ENSP00000416799.1, ENST00000422556.1
    Conserved Domains (2) summary
    cl15262
    Location:88176
    PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins
    cl22851
    Location:459511
    PHD_SF; PHD finger superfamily
  2. NM_006038.4NP_006029.1  spermatogenesis-associated protein 2

    See identical proteins and their annotated locations for NP_006029.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AK295536, AL031685, BC009481, N62318
    Consensus CDS
    CCDS13422.1
    UniProtKB/Swiss-Prot
    Q9UM82
    UniProtKB/TrEMBL
    B4DID4
    Related
    ENSP00000289431.5, ENST00000289431.10
    Conserved Domains (2) summary
    cl15262
    Location:88176
    PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins
    cl22851
    Location:459511
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    49903391..49915529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723894.1XP_006723957.1  spermatogenesis-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006723957.1

    UniProtKB/Swiss-Prot
    Q9UM82
    Conserved Domains (2) summary
    cl15262
    Location:88176
    PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins
    cl22851
    Location:459511
    PHD_SF; PHD finger superfamily
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