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NUP58 nucleoporin 58 [ Homo sapiens (human) ]

Gene ID: 9818, updated on 21-Dec-2019

Summary

Official Symbol
NUP58provided by HGNC
Official Full Name
nucleoporin 58provided by HGNC
Primary source
HGNC:HGNC:20261
See related
Ensembl:ENSG00000139496 MIM:607615
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NUP45; NUPL1; PRO2463
Summary
This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 26.3), thyroid (RPKM 10.4) and 24 other tissues See more
Orthologs

Genomic context

See NUP58 in Genome Data Viewer
Location:
13q12.13
Exon count:
18
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (25301084..25349795)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (25875222..25916561)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370121 Neighboring gene myotubularin related protein 6 Neighboring gene CRISPRi-validated cis-regulatory element chr13.188 Neighboring gene elongin B pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0410

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
intracellular transport of virus TAS
Traceable Author Statement
more info
 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
protein heterotetramerization IEA
Inferred from Electronic Annotation
more info
 
protein heterotrimerization IEA
Inferred from Electronic Annotation
more info
 
protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
protein sumoylation TAS
Traceable Author Statement
more info
 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
regulation of gene silencing by miRNA TAS
Traceable Author Statement
more info
 
regulation of glycolytic process TAS
Traceable Author Statement
more info
 
regulation of protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
tRNA export from nucleus TAS
Traceable Author Statement
more info
 
viral process TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
host cell IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope TAS
Traceable Author Statement
more info
 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nucleoporin p58/p45
Names
58 kDa nucleoporin
nucleoporin 58kDa
nucleoporin like 1
nucleoporin-like protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033956.1 RefSeqGene

    Range
    5098..45894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001008564.2NP_001008564.1  nucleoporin p58/p45 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b).
    Source sequence(s)
    AF113020, AK025800, AL138958, BC001104, BG330006, BP249090
    Consensus CDS
    CCDS31949.1
    UniProtKB/Swiss-Prot
    Q9BVL2
    Related
    ENSP00000371137.3, ENST00000381718.7
    Conserved Domains (2) summary
    pfam10154
    Location:232410
    DUF2362; Uncharacterized conserved protein (DUF2362)
    pfam15967
    Location:22587
    Nucleoporin_FG2; Nucleoporin FG repeated region
  2. NM_014089.4NP_054808.1  nucleoporin p58/p45 isoform a

    See identical proteins and their annotated locations for NP_054808.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AF113020, AK025800, AL138958, BC001104, BP249090
    Consensus CDS
    CCDS9314.1
    UniProtKB/Swiss-Prot
    Q9BVL2
    Related
    ENSP00000371155.3, ENST00000381736.8
    Conserved Domains (1) summary
    cl25599
    Location:3599
    Nucleoporin_FG2; Nucleoporin FG repeated region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    25301084..25349795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535329.3XP_011533631.1  nucleoporin p58/p45 isoform X3

    See identical proteins and their annotated locations for XP_011533631.1

    Conserved Domains (1) summary
    pfam15967
    Location:1325
    Nucleoporin_FG2; Nucleoporin FG repeated region
  2. XM_017020881.2XP_016876370.1  nucleoporin p58/p45 isoform X3

    Conserved Domains (1) summary
    pfam15967
    Location:1325
    Nucleoporin_FG2; Nucleoporin FG repeated region
  3. XM_011535328.2XP_011533630.1  nucleoporin p58/p45 isoform X1

    Conserved Domains (2) summary
    pfam10154
    Location:244422
    DUF2362; Uncharacterized conserved protein (DUF2362)
    pfam15967
    Location:22544
    Nucleoporin_FG2; Nucleoporin FG repeated region
  4. XM_005266600.4XP_005266657.1  nucleoporin p58/p45 isoform X2

    Related
    ENSP00000418555.1, ENST00000463407.5
    Conserved Domains (2) summary
    pfam10154
    Location:244422
    DUF2362; Uncharacterized conserved protein (DUF2362)
    pfam15967
    Location:22566
    Nucleoporin_FG2; Nucleoporin FG repeated region

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001008565.1: Suppressed sequence

    Description
    NM_001008565.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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