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SCRN1 secernin 1 [ Homo sapiens (human) ]

Gene ID: 9805, updated on 6-May-2021

Summary

Official Symbol
SCRN1provided by HGNC
Official Full Name
secernin 1provided by HGNC
Primary source
HGNC:HGNC:22192
See related
Ensembl:ENSG00000136193 MIM:614965
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SES1
Summary
This gene likely encodes a member of the secernin family of proteins. A similar protein in rat functions in regulation of exocytosis in mast cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Expression
Broad expression in brain (RPKM 69.1), testis (RPKM 17.1) and 22 other tissues See more
Orthologs
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Genomic context

See SCRN1 in Genome Data Viewer
Location:
7p14.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (29920103..29990289, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (29959719..30029905, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr7.1421 Neighboring gene WAS/WASL interacting protein family member 3 Neighboring gene FKBP14 antisense RNA 1 Neighboring gene FKBP prolyl isomerase 14 Neighboring gene pleckstrin homology domain containing A8 Neighboring gene uncharacterized LOC105375216

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0193

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type exopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables dipeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047114.1 RefSeqGene

    Range
    5001..75187
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145513.1NP_001138985.1  secernin-1 isoform a

    See identical proteins and their annotated locations for NP_001138985.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    AA910381, AB071705, BC040492, DC307846
    Consensus CDS
    CCDS5422.1
    UniProtKB/Swiss-Prot
    Q12765
    UniProtKB/TrEMBL
    A0A090N7T9
    Related
    ENSP00000409068.1, ENST00000426154.5
    Conserved Domains (1) summary
    cl00467
    Location:18227
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  2. NM_001145514.1NP_001138986.1  secernin-1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AA910381, AB071705, AK295172
    Consensus CDS
    CCDS47567.1
    UniProtKB/Swiss-Prot
    Q12765
    Related
    ENSP00000388942.1, ENST00000434476.6
    Conserved Domains (1) summary
    cl00467
    Location:38247
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  3. NM_001145515.2NP_001138987.1  secernin-1 isoform c

    See identical proteins and their annotated locations for NP_001138987.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter than isoform 1.
    Source sequence(s)
    AA910381, AB071705, AK295713, DC370097
    Consensus CDS
    CCDS47568.1
    UniProtKB/Swiss-Prot
    Q12765
    UniProtKB/TrEMBL
    A0A024RA21
    Related
    ENSP00000414245.2, ENST00000425819.6
    Conserved Domains (1) summary
    cl00467
    Location:2159
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  4. NM_014766.5NP_055581.3  secernin-1 isoform a

    See identical proteins and their annotated locations for NP_055581.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    AA910381, AB071705, DC370097
    Consensus CDS
    CCDS5422.1
    UniProtKB/Swiss-Prot
    Q12765
    UniProtKB/TrEMBL
    A0A090N7T9
    Related
    ENSP00000242059.5, ENST00000242059.10
    Conserved Domains (1) summary
    cl00467
    Location:18227
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    29920103..29990289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447007.1XP_024302775.1  secernin-1 isoform X1

    Conserved Domains (1) summary
    cl00467
    Location:18227
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
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