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MRPL19 mitochondrial ribosomal protein L19 [ Homo sapiens (human) ]

Gene ID: 9801, updated on 21-Dec-2019

Summary

Official Symbol
MRPL19provided by HGNC
Official Full Name
mitochondrial ribosomal protein L19provided by HGNC
Primary source
HGNC:HGNC:14052
See related
Ensembl:ENSG00000115364 MIM:611832
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RLX1; L19mt; MRPL15; RPML15; MRP-L15; MRP-L19
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 7.4), kidney (RPKM 7.1) and 25 other tissues See more
Orthologs

Genomic context

See MRPL19 in Genome Data Viewer
Location:
2p12
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (75646783..75662206)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (75873909..75889334)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 57 Neighboring gene uncharacterized LOC101927884 Neighboring gene eva-1 homolog A, regulator of programmed cell death Neighboring gene Sharpr-MPRA regulatory region 13771 Neighboring gene SPT4 homolog, DSIF elongation factor subunit pseudogene Neighboring gene uncharacterized LOC105374813 Neighboring gene GC-rich sequence DNA-binding factor 2 Neighboring gene SUCLA2 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0104, MGC20675

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
39S ribosomal protein L19, mitochondrial
Names
39S ribosomal protein L15, mitochondrial
L15mt
mitochondrial large ribosomal subunit protein bL19m

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014763.4NP_055578.2  39S ribosomal protein L19, mitochondrial

    See identical proteins and their annotated locations for NP_055578.2

    Status: REVIEWED

    Source sequence(s)
    AC005034, BQ432684
    Consensus CDS
    CCDS1960.2
    UniProtKB/Swiss-Prot
    P49406
    Related
    ENSP00000377486.2, ENST00000393909.7
    Conserved Domains (1) summary
    cl00406
    Location:108192
    Ribosomal_L19; Ribosomal protein L19

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    75646783..75662206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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