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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001270975.2 → NP_001257904.1 IST1 homolog isoform a
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes isoform a (also known as hIST1c).
- Source sequence(s)
-
AC009127, BC103745
- Consensus CDS
-
CCDS59272.1
- UniProtKB/Swiss-Prot
- A8KAH5, J3QLU7, P53990, Q3SYM4, Q9BQ81, Q9BWN2
- Related
- ENSP00000368076.6, ENST00000378799.11
- Conserved Domains (1) summary
-
- pfam03398
Location:12 → 176
- Ist1; Regulator of Vps4 activity in the MVB pathway
-
NM_001270976.1 → NP_001257905.1 IST1 homolog isoform c
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an alternate in-frame start codon, compared to variant 1. The encoded isoform (c) has a longer N-terminus, compared to isoform a.
- Source sequence(s)
-
AC009127, AK293040, DA332434
- Consensus CDS
-
CCDS59271.1
- UniProtKB/Swiss-Prot
- A8KAH5, J3QLU7, P53990, Q3SYM4, Q9BQ81, Q9BWN2
- Related
- ENSP00000438399.1, ENST00000535424.5
- Conserved Domains (1) summary
-
- pfam03398
Location:26 → 189
- Ist1; Regulator of Vps4 activity in the MVB pathway
-
NM_001270977.2 → NP_001257906.1 IST1 homolog isoform d
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (d, also known as hIST1d) is shorter than isoform a.
- Source sequence(s)
-
AC009127, BC000116, DA698420
- Consensus CDS
-
CCDS59273.1
- UniProtKB/Swiss-Prot
- A8KAH5, J3QLU7, P53990, Q3SYM4, Q9BQ81, Q9BWN2
- UniProtKB/TrEMBL
-
A8K5S3
- Related
- ENSP00000368075.5, ENST00000378798.9
- Conserved Domains (1) summary
-
- pfam03398
Location:13 → 176
- Ist1; Regulator of Vps4 activity in the MVB pathway
-
NM_001270978.2 → NP_001257907.1 IST1 homolog isoform e
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) lacks three exons in the coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (e) is shorter than isoform a. Both variants 5 and 6 encode the same isoform (e).
- Source sequence(s)
-
AC009127, AK057902, BX364250, DA698420
- Consensus CDS
-
CCDS59274.1
- UniProtKB/TrEMBL
-
B4DXC9
- Related
- ENSP00000463711.1, ENST00000538850.5
- Conserved Domains (1) summary
-
- pfam03398
Location:1 → 28
- Ist1; Regulator of Vps4 activity in the MVB pathway
-
NM_001270979.1 → NP_001257908.1 IST1 homolog isoform e
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) lacks four exons in the coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (e) is shorter than isoform a. Both variants 5 and 6 encode the same isoform (e).
- Source sequence(s)
-
AC009127, AK301918, DA698420
- Consensus CDS
-
CCDS59274.1
- UniProtKB/TrEMBL
-
B4DXC9
- Related
- ENSP00000475853.1, ENST00000606369.5
- Conserved Domains (1) summary
-
- pfam03398
Location:1 → 28
- Ist1; Regulator of Vps4 activity in the MVB pathway
-
NM_014761.4 → NP_055576.2 IST1 homolog isoform b
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b, also known as hIST1b) has a distinct C-terminus and is shorter than isoform a.
- Source sequence(s)
-
AC009127, BC000430, DA698420
- Consensus CDS
-
CCDS10905.1
- UniProtKB/TrEMBL
-
B4DM80
- Related
- ENSP00000330408.8, ENST00000329908.12
- Conserved Domains (1) summary
-
- pfam03398
Location:13 → 176
- Ist1; Regulator of Vps4 activity in the MVB pathway
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000016.10 Reference GRCh38.p14 Primary Assembly
- Range
-
71894408..71931199
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate T2T-CHM13v2.0
Genomic
-
NC_060940.1 Alternate T2T-CHM13v2.0
- Range
-
77711542..77748323
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)