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MTSS1 MTSS I-BAR domain containing 1 [ Homo sapiens (human) ]

Gene ID: 9788, updated on 22-Aug-2021

Summary

Official Symbol
MTSS1provided by HGNC
Official Full Name
MTSS I-BAR domain containing 1provided by HGNC
Primary source
HGNC:HGNC:20443
See related
Ensembl:ENSG00000170873 MIM:608486
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIM; MIMA; MIMB
Expression
Ubiquitous expression in liver (RPKM 5.7), adrenal (RPKM 5.6) and 25 other tissues See more
Orthologs
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Genomic context

See MTSS1 in Genome Data Viewer
Location:
8q24.13
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (124550784..124728473, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (125563025..125740714, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene TatD DNase domain containing 1 Neighboring gene microRNA 6844 Neighboring gene NADH:ubiquinone oxidoreductase subunit B9 Neighboring gene uncharacterized LOC105375740 Neighboring gene uncharacterized LOC105375741 Neighboring gene microRNA 4662b Neighboring gene microRNA 4662a

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
GeneReviews: Not available
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ44694, KIAA0429, DKFZp781P2223

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin monomer binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
involved_in adherens junction maintenance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular response to fluid shear stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in epithelial cell proliferation involved in renal tubule morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glomerulus morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in microspike assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in nephron tubule epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in plasma membrane organization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in renal tubule morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in endocytic vesicle TAS
Traceable Author Statement
more info
PubMed 
is_active_in intrinsic component of the cytoplasmic side of the plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in ruffle NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
protein MTSS 1
Names
MTSS1, I-BAR domain containing
metastasis suppressor 1
metastasis suppressor YGL-1
metastasis suppressor protein 1
missing in metastasis protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282971.2NP_001269900.1  protein MTSS 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC090198, AJ710067, AK027015, DA790325
    Consensus CDS
    CCDS64969.1
    UniProtKB/Swiss-Prot
    O43312
    Related
    ENSP00000322804.5, ENST00000325064.9
    Conserved Domains (3) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:330729
    PHA03247; large tegument protein UL36; Provisional
    cd22060
    Location:728758
    WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)
  2. NM_001282974.2NP_001269903.1  protein MTSS 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AC090198, AF086645, AJ710067, DA790325, EF560715
    Consensus CDS
    CCDS64968.1
    UniProtKB/Swiss-Prot
    O43312
    UniProtKB/TrEMBL
    A5YM41
    Related
    ENSP00000367256.3, ENST00000378017.7
    Conserved Domains (3) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:400700
    PHA03247; large tegument protein UL36; Provisional
    cd22060
    Location:699729
    WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)
  3. NM_001363294.2NP_001350223.1  protein MTSS 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC090198, AF086645, AJ710067, CN348724, DA790325
    Conserved Domains (3) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam02205
    Location:723749
    WH2; WH2 motif
    cl26464
    Location:325724
    Atrophin-1; Atrophin-1 family
  4. NM_001363295.2NP_001350224.1  protein MTSS 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC090198, AF086645, AJ710067, DA447614, DA790325
    Conserved Domains (3) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:326708
    PHA03247; large tegument protein UL36; Provisional
    cd22060
    Location:707737
    WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)
  5. NM_001363296.2NP_001350225.1  protein MTSS 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC090198, AJ710067, AK027015, BY993850, DA227466, DA785323, DA790325
    Conserved Domains (3) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:404704
    PHA03247; large tegument protein UL36; Provisional
    cd22060
    Location:703733
    WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)
  6. NM_001363297.2NP_001350226.1  protein MTSS 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC090198, AJ710067, AK027015, BY993850, DA227466, DA785323, DA790325
    Conserved Domains (4) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:567695
    Gag_spuma; Spumavirus gag protein
    pfam02205
    Location:702728
    WH2; WH2 motif
    cl26464
    Location:403703
    Atrophin-1; Atrophin-1 family
  7. NM_001363298.2NP_001350227.1  protein MTSS 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC090198, AJ710067, AK027015, BY993850, DA225605, DA227466, DA785323, DA790325
    Conserved Domains (4) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:563691
    Gag_spuma; Spumavirus gag protein
    pfam02205
    Location:698724
    WH2; WH2 motif
    cl26464
    Location:399699
    Atrophin-1; Atrophin-1 family
  8. NM_001363299.2NP_001350228.1  protein MTSS 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC090198, AJ710067, AK027015, BU145296, BY993850, DA785323, DA790325, HY339502
    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    cl26464
    Location:338664
    Atrophin-1; Atrophin-1 family
  9. NM_001363300.2NP_001350229.1  protein MTSS 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC090198, AJ710067, AK027015, BU145296, BY993850, DA785323, DA790325, HY339502
    Conserved Domains (2) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    cl26464
    Location:334660
    Atrophin-1; Atrophin-1 family
  10. NM_001363301.2NP_001350230.1  protein MTSS 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC090198, AJ710067, AK027015, BU145296, BY993850, DA785323, DA790325, HY339502
    Conserved Domains (3) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam02205
    Location:658684
    WH2; WH2 motif
    cl26464
    Location:333659
    Atrophin-1; Atrophin-1 family
  11. NM_001363302.2NP_001350231.1  protein MTSS 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC090198, AF086645, AJ710067, DA790325
    Conserved Domains (2) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    cl26464
    Location:326644
    Atrophin-1; Atrophin-1 family
  12. NM_014751.6NP_055566.3  protein MTSS 1 isoform 2

    See identical proteins and their annotated locations for NP_055566.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC090198, AF086645, AJ710067, DA790325
    Consensus CDS
    CCDS6353.1
    UniProtKB/Swiss-Prot
    O43312
    Related
    ENSP00000429064.1, ENST00000518547.6
    Conserved Domains (3) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:326725
    PHA03247; large tegument protein UL36; Provisional
    cd22060
    Location:724754
    WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    124550784..124728473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014086.2XP_016869575.1  protein MTSS 1 isoform X4

    Conserved Domains (2) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:697825
    Gag_spuma; Spumavirus gag protein
  2. XM_017014092.2XP_016869581.1  protein MTSS 1 isoform X13

    Conserved Domains (2) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:633761
    Gag_spuma; Spumavirus gag protein
  3. XM_006716701.2XP_006716764.1  protein MTSS 1 isoform X3

    Conserved Domains (2) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:698826
    Gag_spuma; Spumavirus gag protein
  4. XM_017014088.2XP_016869577.1  protein MTSS 1 isoform X7

    Conserved Domains (2) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:673801
    Gag_spuma; Spumavirus gag protein
  5. XM_006716704.2XP_006716767.1  protein MTSS 1 isoform X16

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:329728
    PHA03247; large tegument protein UL36; Provisional
  6. XM_006716706.2XP_006716769.1  protein MTSS 1 isoform X26

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:341647
    PHA03247; large tegument protein UL36; Provisional
  7. XM_006716703.2XP_006716766.1  protein MTSS 1 isoform X15

    Conserved Domains (3) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:330756
    PHA03247; large tegument protein UL36; Provisional
    pfam03276
    Location:620748
    Gag_spuma; Spumavirus gag protein
  8. XM_005251113.2XP_005251170.1  protein MTSS 1 isoform X11

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:637765
    Gag_spuma; Spumavirus gag protein
  9. XM_006716705.2XP_006716768.1  protein MTSS 1 isoform X18

    Conserved Domains (3) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    PHA03247
    Location:330712
    PHA03247; large tegument protein UL36; Provisional
    cd22060
    Location:711741
    WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)
  10. XM_006716702.2XP_006716765.1  protein MTSS 1 isoform X5

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:685813
    Gag_spuma; Spumavirus gag protein
  11. XM_005251111.2XP_005251168.1  protein MTSS 1 isoform X1

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:702830
    Gag_spuma; Spumavirus gag protein
  12. XM_017014089.2XP_016869578.1  protein MTSS 1 isoform X8

    Conserved Domains (2) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:672800
    Gag_spuma; Spumavirus gag protein
  13. XM_006716700.2XP_006716763.1  protein MTSS 1 isoform X2

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:701829
    Gag_spuma; Spumavirus gag protein
  14. XM_017014087.2XP_016869576.1  protein MTSS 1 isoform X6

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:677805
    Gag_spuma; Spumavirus gag protein
  15. XM_011517403.1XP_011515705.1  protein MTSS 1 isoform X12

    Conserved Domains (2) summary
    pfam03276
    Location:635763
    Gag_spuma; Spumavirus gag protein
    cl12013
    Location:1174
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  16. XM_017014091.1XP_016869580.1  protein MTSS 1 isoform X10

    Conserved Domains (2) summary
    pfam03276
    Location:639767
    Gag_spuma; Spumavirus gag protein
    cl12013
    Location:1178
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  17. XM_011517404.2XP_011515706.1  protein MTSS 1 isoform X14

    Conserved Domains (2) summary
    pfam03276
    Location:621749
    Gag_spuma; Spumavirus gag protein
    cl12013
    Location:1160
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  18. XM_017014090.2XP_016869579.1  protein MTSS 1 isoform X9

    Conserved Domains (2) summary
    pfam03276
    Location:647775
    Gag_spuma; Spumavirus gag protein
    cl12013
    Location:15186
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  19. XM_024447351.1XP_024303119.1  protein MTSS 1 isoform X29

    Conserved Domains (1) summary
    pfam15324
    Location:335489
    TALPID3; Hedgehog signalling target
  20. XM_011517407.1XP_011515709.1  protein MTSS 1 isoform X30

    Conserved Domains (1) summary
    pfam03276
    Location:344472
    Gag_spuma; Spumavirus gag protein
  21. XM_017014101.1XP_016869590.1  protein MTSS 1 isoform X28

    Conserved Domains (3) summary
    PHA03247
    Location:245619
    PHA03247; large tegument protein UL36; Provisional
    pfam03276
    Location:483611
    Gag_spuma; Spumavirus gag protein
    cl12013
    Location:1156
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
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