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MTSS1 MTSS1, I-BAR domain containing [ Homo sapiens (human) ]

Gene ID: 9788, updated on 5-Aug-2018

Summary

Official Symbol
MTSS1provided by HGNC
Official Full Name
MTSS1, I-BAR domain containingprovided by HGNC
Primary source
HGNC:HGNC:20443
See related
Ensembl:ENSG00000170873 MIM:608486; Vega:OTTHUMG00000048189
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIM; MIMA; MIMB
Expression
Ubiquitous expression in liver (RPKM 5.7), adrenal (RPKM 5.6) and 25 other tissues See more
Orthologs

Genomic context

See MTSS1 in Genome Data Viewer
Location:
8q24.13
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (124550770..124728507, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (125563025..125740730, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene TatD DNase domain containing 1 Neighboring gene microRNA 6844 Neighboring gene NADH:ubiquinone oxidoreductase subunit B9 Neighboring gene uncharacterized LOC105375740 Neighboring gene uncharacterized LOC105375741 Neighboring gene microRNA 4662b Neighboring gene microRNA 4662a

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ44694, KIAA0429, DKFZp781P2223

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin monomer binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
cellular response to fluid shear stress ISS
Inferred from Sequence or Structural Similarity
more info
 
epithelial cell proliferation involved in renal tubule morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
glomerulus morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
microspike assembly NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
nephron tubule epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane organization IEA
Inferred from Electronic Annotation
more info
 
renal tubule morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
endocytic vesicle TAS
Traceable Author Statement
more info
PubMed 
ruffle NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
metastasis suppressor protein 1
Names
metastasis suppressor 1
metastasis suppressor YGL-1
missing in metastasis protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282971.1NP_001269900.1  metastasis suppressor protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC090198, AJ710067, AK027015, DA790325
    Consensus CDS
    CCDS64969.1
    UniProtKB/Swiss-Prot
    O43312
    Related
    ENSP00000322804.5, OTTHUMP00000228306, ENST00000325064.9, OTTHUMT00000381615
    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam02205
    Location:728754
    WH2; WH2 motif
  2. NM_001282974.1NP_001269903.1  metastasis suppressor protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AC090198, AF086645, AJ710067, DA790325, EF560715
    Consensus CDS
    CCDS64968.1
    UniProtKB/Swiss-Prot
    O43312
    UniProtKB/TrEMBL
    A5YM41
    Related
    ENSP00000367256.3, OTTHUMP00000228225, ENST00000378017.7, OTTHUMT00000109623
    Conserved Domains (2) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam02205
    Location:699725
    WH2; WH2 motif
  3. NM_001363294.1NP_001350223.1  metastasis suppressor protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC090198, AF086645, AJ710067, CN348724, DA790325
    Conserved Domains (3) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam02205
    Location:723749
    WH2; WH2 motif
    cl26464
    Location:325724
    Atrophin-1; Atrophin-1 family
  4. NM_001363295.1NP_001350224.1  metastasis suppressor protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC090198, AF086645, AJ710067, DA447614, DA790325
    Conserved Domains (3) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam02205
    Location:707733
    WH2; WH2 motif
    cl26464
    Location:326708
    Atrophin-1; Atrophin-1 family
  5. NM_001363296.1NP_001350225.1  metastasis suppressor protein 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC090198, AJ710067, AK027015, BY993850, DA227466, DA785323, DA790325
    Conserved Domains (4) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:568696
    Gag_spuma; Spumavirus gag protein
    pfam02205
    Location:703729
    WH2; WH2 motif
    cl26464
    Location:404704
    Atrophin-1; Atrophin-1 family
  6. NM_001363297.1NP_001350226.1  metastasis suppressor protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC090198, AJ710067, AK027015, BY993850, DA227466, DA785323, DA790325
    Conserved Domains (4) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:567695
    Gag_spuma; Spumavirus gag protein
    pfam02205
    Location:702728
    WH2; WH2 motif
    cl26464
    Location:403703
    Atrophin-1; Atrophin-1 family
  7. NM_001363298.1NP_001350227.1  metastasis suppressor protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC090198, AJ710067, AK027015, BY993850, DA225605, DA227466, DA785323, DA790325
    Conserved Domains (4) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:563691
    Gag_spuma; Spumavirus gag protein
    pfam02205
    Location:698724
    WH2; WH2 motif
    cl26464
    Location:399699
    Atrophin-1; Atrophin-1 family
  8. NM_001363299.1NP_001350228.1  metastasis suppressor protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC090198, AJ710067, AK027015, BU145296, BY993850, DA785323, DA790325, HY339502
    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    cl26464
    Location:338664
    Atrophin-1; Atrophin-1 family
  9. NM_001363300.1NP_001350229.1  metastasis suppressor protein 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC090198, AJ710067, AK027015, BU145296, BY993850, DA785323, DA790325, HY339502
    Conserved Domains (2) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    cl26464
    Location:334660
    Atrophin-1; Atrophin-1 family
  10. NM_001363301.1NP_001350230.1  metastasis suppressor protein 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC090198, AJ710067, AK027015, BU145296, BY993850, DA785323, DA790325, HY339502
    Conserved Domains (3) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam02205
    Location:658684
    WH2; WH2 motif
    cl26464
    Location:333659
    Atrophin-1; Atrophin-1 family
  11. NM_001363302.1NP_001350231.1  metastasis suppressor protein 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC090198, AF086645, AJ710067, DA790325
    Conserved Domains (2) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    cl26464
    Location:326644
    Atrophin-1; Atrophin-1 family
  12. NM_014751.5NP_055566.3  metastasis suppressor protein 1 isoform 2

    See identical proteins and their annotated locations for NP_055566.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC090198, AF086645, AJ710067, DA790325
    Consensus CDS
    CCDS6353.1
    UniProtKB/Swiss-Prot
    O43312
    Related
    ENSP00000429064.1, OTTHUMP00000045859, ENST00000518547.5, OTTHUMT00000109625
    Conserved Domains (2) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam02205
    Location:724750
    WH2; WH2 motif

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    124550770..124728507 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014099.2XP_016869588.1  metastasis suppressor protein 1 isoform X25

    Conserved Domains (3) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam02205
    Location:658684
    WH2; WH2 motif
    cl26464
    Location:333659
    Atrophin-1; Atrophin-1 family
  2. XM_017014093.2XP_016869582.1  metastasis suppressor protein 1 isoform X17

    Conserved Domains (3) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam02205
    Location:723749
    WH2; WH2 motif
    cl26464
    Location:325724
    Atrophin-1; Atrophin-1 family
  3. XM_017014086.2XP_016869575.1  metastasis suppressor protein 1 isoform X4

  4. XM_017014097.2XP_016869586.1  metastasis suppressor protein 1 isoform X22

    Conserved Domains (4) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:563691
    Gag_spuma; Spumavirus gag protein
    pfam02205
    Location:698724
    WH2; WH2 motif
    cl26464
    Location:399699
    Atrophin-1; Atrophin-1 family
  5. XM_017014100.2XP_016869589.1  metastasis suppressor protein 1 isoform X27

    Conserved Domains (2) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    cl26464
    Location:326644
    Atrophin-1; Atrophin-1 family
  6. XM_017014098.2XP_016869587.1  metastasis suppressor protein 1 isoform X24

    Conserved Domains (2) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    cl26464
    Location:334660
    Atrophin-1; Atrophin-1 family
  7. XM_017014092.2XP_016869581.1  metastasis suppressor protein 1 isoform X13

  8. XM_017014094.2XP_016869583.1  metastasis suppressor protein 1 isoform X19

    Conserved Domains (3) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam02205
    Location:707733
    WH2; WH2 motif
    cl26464
    Location:326708
    Atrophin-1; Atrophin-1 family
  9. XM_006716701.2XP_006716764.1  metastasis suppressor protein 1 isoform X3

    Conserved Domains (2) summary
    cd07643
    Location:7237
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam02205
    Location:833859
    WH2; WH2 motif
  10. XM_017014088.2XP_016869577.1  metastasis suppressor protein 1 isoform X7

  11. XM_006716704.2XP_006716767.1  metastasis suppressor protein 1 isoform X16

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam02205
    Location:727753
    WH2; WH2 motif
  12. XM_017014096.2XP_016869585.1  metastasis suppressor protein 1 isoform X21

    Conserved Domains (4) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:567695
    Gag_spuma; Spumavirus gag protein
    pfam02205
    Location:702728
    WH2; WH2 motif
    cl26464
    Location:403703
    Atrophin-1; Atrophin-1 family
  13. XM_006716706.2XP_006716769.1  metastasis suppressor protein 1 isoform X26

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam02205
    Location:646672
    WH2; WH2 motif
  14. XM_006716703.2XP_006716766.1  metastasis suppressor protein 1 isoform X15

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam02205
    Location:755781
    WH2; WH2 motif
  15. XM_005251118.2XP_005251175.1  metastasis suppressor protein 1 isoform X23

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    cl26464
    Location:338664
    Atrophin-1; Atrophin-1 family
  16. XM_005251113.2XP_005251170.1  metastasis suppressor protein 1 isoform X11

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam02205
    Location:772798
    WH2; WH2 motif
  17. XM_006716705.2XP_006716768.1  metastasis suppressor protein 1 isoform X18

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam02205
    Location:711737
    WH2; WH2 motif
  18. XM_006716702.2XP_006716765.1  metastasis suppressor protein 1 isoform X5

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam02205
    Location:820846
    WH2; WH2 motif
  19. XM_005251111.2XP_005251168.1  metastasis suppressor protein 1 isoform X1

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam02205
    Location:837863
    WH2; WH2 motif
  20. XM_017014095.2XP_016869584.1  metastasis suppressor protein 1 isoform X20

    Conserved Domains (4) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam03276
    Location:568696
    Gag_spuma; Spumavirus gag protein
    pfam02205
    Location:703729
    WH2; WH2 motif
    cl26464
    Location:404704
    Atrophin-1; Atrophin-1 family
  21. XM_017014089.2XP_016869578.1  metastasis suppressor protein 1 isoform X8

  22. XM_006716700.2XP_006716763.1  metastasis suppressor protein 1 isoform X2

    Conserved Domains (2) summary
    cd07643
    Location:7241
    I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
    pfam02205
    Location:836862
    WH2; WH2 motif
  23. XM_017014087.2XP_016869576.1  metastasis suppressor protein 1 isoform X6

  24. XM_011517403.1XP_011515705.1  metastasis suppressor protein 1 isoform X12

    Conserved Domains (2) summary
    pfam02205
    Location:770796
    WH2; WH2 motif
    cl12013
    Location:1174
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  25. XM_017014091.1XP_016869580.1  metastasis suppressor protein 1 isoform X10

  26. XM_011517404.2XP_011515706.1  metastasis suppressor protein 1 isoform X14

    Conserved Domains (2) summary
    pfam02205
    Location:756782
    WH2; WH2 motif
    cl12013
    Location:1160
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  27. XM_017014090.2XP_016869579.1  metastasis suppressor protein 1 isoform X9

  28. XM_024447351.1XP_024303119.1  metastasis suppressor protein 1 isoform X29

    Conserved Domains (2) summary
    pfam03276
    Location:361489
    Gag_spuma; Spumavirus gag protein
    pfam02205
    Location:496522
    WH2; WH2 motif
  29. XM_011517407.1XP_011515709.1  metastasis suppressor protein 1 isoform X30

    Conserved Domains (1) summary
    pfam02205
    Location:479505
    WH2; WH2 motif
  30. XM_017014101.1XP_016869590.1  metastasis suppressor protein 1 isoform X28

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