Exd2 exonuclease 3'-5' domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Exd2provided by MGI
Official Full Name: exonuclease 3'-5' domain containing 2provided by MGI
Primary source: MGI:MGI:1922485
See related: Ensembl:ENSMUSG00000032705 AllianceGenome:MGI:1922485
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Exdl2; 4930539P14Rik
Summary: Predicted to enable 3'-5' exonuclease activity; metal ion binding activity; and protein homodimerization activity. Predicted to be involved in DNA double-strand break processing; double-strand break repair via homologous recombination; and replication fork processing. Predicted to be located in intermediate filament cytoskeleton; mitochondrial outer membrane; and site of DNA damage. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; ganglia; and neural retina. Orthologous to human EXD2 (exonuclease 3'-5' domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cortex adult (RPKM 19.6), frontal lobe adult (RPKM 18.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C3; 12 36.73 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (80509869..80544909)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (80463095..80498135)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intermitochondrial cement (IMC) harbors piRNA biogenesis machinery and exonuclease domain-containing proteins EXD1 and EXD2 in mouse spermatocytes.
Title: Intermitochondrial cement (IMC) harbors piRNA biogenesis machinery and exonuclease domain-containing proteins EXD1 and EXD2 in mouse spermatocytes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW557802 (e-PCR)
- UniSTS:208831

RH127215 (e-PCR)
- UniSTS:208832

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3'-5' exonuclease activity	ISO Inferred from Sequence Orthology more info
enables 3'-5' exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables 3'-5'-DNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables 3'-5'-DNA exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables 3'-5'-RNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables 3'-5'-RNA exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables single-stranded DNA 3'-5' DNA exonuclease activity	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA 3'-5' DNA exonuclease activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA double-strand break processing	IEA Inferred from Electronic Annotation more info
involved_in DNA double-strand break processing	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in nucleic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in replication fork processing	ISO Inferred from Sequence Orthology more info
involved_in replication fork processing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in intermediate filament cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in site of DNA damage	ISO Inferred from Sequence Orthology more info
located_in site of DNA damage	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: exonuclease 3'-5' domain-containing protein 2

Names: 3'-5' exoribonuclease EXD2; exonuclease 3''-5'' domain-like 2; exonuclease 3'-5' domain-like-containing protein 2

NP_598559.2

EC 3.1.11.1

XP_006516477.1

EC 3.1.11.1

XP_006516478.1

EC 3.1.11.1

XP_011242527.1

EC 3.1.11.1

XP_030102871.1

EC 3.1.11.1

XP_030102872.1

EC 3.1.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133798.3 → NP_598559.2 exonuclease 3'-5' domain-containing protein 2

Status: VALIDATED

Source sequence(s)

AK162206, AK164329, AK167692

Consensus CDS

CCDS49098.1

UniProtKB/Swiss-Prot

F8WID1, Q3TPJ5, Q3TS84, Q8VEG4

UniProtKB/TrEMBL

Q3UIJ1

Related

ENSMUSP00000043049.9, ENSMUST00000038185.10

Conserved Domains (1) summary

cd06141
Location:111 → 287

WRN_exo; DEDDy 3'-5' exonuclease domain of WRN and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

80509869..80544909

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244225.3 → XP_011242527.1 exonuclease 3'-5' domain-containing protein 2 isoform X1
XM_006516414.5 → XP_006516477.1 exonuclease 3'-5' domain-containing protein 2 isoform X3
XM_006516415.5 → XP_006516478.1 exonuclease 3'-5' domain-containing protein 2 isoform X4
XM_030247011.2 → XP_030102871.1 exonuclease 3'-5' domain-containing protein 2 isoform X2

Conserved Domains (1) summary

cd06141
Location:1 → 133

WRN_exo; DEDDy 3'-5' exonuclease domain of WRN and similar proteins
XM_030247012.2 → XP_030102872.1 exonuclease 3'-5' domain-containing protein 2 isoform X4