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TM9SF4 transmembrane 9 superfamily member 4 [ Homo sapiens (human) ]

Gene ID: 9777, updated on 4-Jun-2020

Summary

Official Symbol
TM9SF4provided by HGNC
Official Full Name
transmembrane 9 superfamily member 4provided by HGNC
Primary source
HGNC:HGNC:30797
See related
Ensembl:ENSG00000101337 MIM:617727
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dJ836N17.2
Expression
Ubiquitous expression in placenta (RPKM 20.7), brain (RPKM 16.4) and 25 other tissues See more
Orthologs

Genomic context

See TM9SF4 in Genome Data Viewer
Location:
20q11.21
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (32109714..32167258)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30697309..30755061)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 482 Neighboring gene HCK proto-oncogene, Src family tyrosine kinase Neighboring gene Sharpr-MPRA regulatory region 10464 Neighboring gene uncharacterized LOC107985403 Neighboring gene ribosomal L24 domain containing 1 pseudogene 6 Neighboring gene testis specific protein Y-linked 26, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0255

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein exit from endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of intracellular pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
vacuolar proton-transporting V-type ATPase complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transmembrane 9 superfamily member 4
Names
dinucleotide oxidase disulfide thiol exchanger 3 superfamily member 4
transmembrane 9 superfamily protein member 4
tumor cannibalism associated protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363731.1NP_001350660.1  transmembrane 9 superfamily member 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BC021107, BM976438, D87444, DC377969
    Consensus CDS
    CCDS86943.1
    Related
    ENSP00000217315.5, ENST00000217315.9
    Conserved Domains (1) summary
    pfam02990
    Location:38582
    EMP70; Endomembrane protein 70
  2. NM_014742.4NP_055557.2  transmembrane 9 superfamily member 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_055557.2

    Status: VALIDATED

    Source sequence(s)
    BC021107, BM976438, D87444, DC381660
    Consensus CDS
    CCDS13196.2
    UniProtKB/Swiss-Prot
    Q92544
    UniProtKB/TrEMBL
    A0A024QYR3
    Related
    ENSP00000381104.2, ENST00000398022.7
    Conserved Domains (1) summary
    pfam02990
    Location:55599
    EMP70; Endomembrane protein 70

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    32109714..32167258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028156.1XP_016883645.1  transmembrane 9 superfamily member 4 isoform X4

    UniProtKB/TrEMBL
    B4DH88
    Conserved Domains (1) summary
    pfam02990
    Location:1506
    EMP70; Endomembrane protein 70
  2. XM_017028160.1XP_016883649.1  transmembrane 9 superfamily member 4 isoform X6

  3. XM_017028158.1XP_016883647.1  transmembrane 9 superfamily member 4 isoform X5

  4. XM_017028154.1XP_016883643.1  transmembrane 9 superfamily member 4 isoform X2

    Conserved Domains (1) summary
    pfam02990
    Location:55571
    EMP70; Endomembrane protein 70
  5. XM_017028161.1XP_016883650.1  transmembrane 9 superfamily member 4 isoform X7

  6. XM_017028155.1XP_016883644.1  transmembrane 9 superfamily member 4 isoform X3

    Conserved Domains (1) summary
    pfam02990
    Location:38554
    EMP70; Endomembrane protein 70
  7. XM_017028157.1XP_016883646.1  transmembrane 9 superfamily member 4 isoform X4

    UniProtKB/TrEMBL
    B4DH88
    Conserved Domains (1) summary
    pfam02990
    Location:1506
    EMP70; Endomembrane protein 70
  8. XM_017028159.1XP_016883648.1  transmembrane 9 superfamily member 4 isoform X6

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