Format

Send to:

Choose Destination

LZTS3 leucine zipper tumor suppressor family member 3 [ Homo sapiens (human) ]

Gene ID: 9762, updated on 28-Nov-2021

Summary

Official Symbol
LZTS3provided by HGNC
Official Full Name
leucine zipper tumor suppressor family member 3provided by HGNC
Primary source
HGNC:HGNC:30139
See related
Ensembl:ENSG00000088899 MIM:610484
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PROSAPIP1
Expression
Broad expression in brain (RPKM 17.2), kidney (RPKM 9.1) and 19 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See LZTS3 in Genome Data Viewer
Location:
20p13
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (3162617..3173549, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3143263..3154195, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 555, pseudogene Neighboring gene UBOX5 antisense RNA 1 Neighboring gene U-box domain containing 5 Neighboring gene FAST kinase domains 5 Neighboring gene uncharacterized LOC107985414 Neighboring gene DDRGK domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0552, RP5-1187M17.10

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in regulation of dendritic spine morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
leucine zipper putative tumor suppressor 3
Names
ProSAP/Shank-interacting protein 1
leucine zipper, putative tumor suppressor family member 3
proline rich synapse associated protein interacting protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282533.2NP_001269462.1  leucine zipper putative tumor suppressor 3 isoform 2

    See identical proteins and their annotated locations for NP_001269462.1

    Status: VALIDATED

    Source sequence(s)
    AB011124, AL121891, BC038860, BU684906, HY126776
    Consensus CDS
    CCDS63218.1
    UniProtKB/Swiss-Prot
    O60299
    Related
    ENSP00000353496.3, ENST00000360342.7
    Conserved Domains (2) summary
    pfam06818
    Location:392591
    Fez1; Fez1
    cl25742
    Location:322451
    ERM; Ezrin/radixin/moesin family
  2. NM_001365618.1NP_001352547.1  leucine zipper putative tumor suppressor 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL121891
    Related
    ENSP00000338166.6, ENST00000337576.7
    Conserved Domains (2) summary
    COG1196
    Location:318515
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:438638
    Fez1
  3. NM_001367609.1NP_001354538.1  leucine zipper putative tumor suppressor 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL121891
    Conserved Domains (2) summary
    COG1196
    Location:348545
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:468668
    Fez1
  4. NM_001388189.1NP_001375118.1  leucine zipper putative tumor suppressor 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL121891
    Conserved Domains (2) summary
    COG1196
    Location:318515
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:438638
    Fez1
  5. NM_001388190.1NP_001375119.1  leucine zipper putative tumor suppressor 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL121891
    Conserved Domains (2) summary
    COG1196
    Location:318515
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:438638
    Fez1
  6. NM_001388191.1NP_001375120.1  leucine zipper putative tumor suppressor 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL121891
    Related
    ENSP00000332123.3, ENST00000329152.7
    Conserved Domains (2) summary
    COG1196
    Location:318515
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:438638
    Fez1
  7. NM_001388192.1NP_001375121.1  leucine zipper putative tumor suppressor 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL121891
    Conserved Domains (2) summary
    COG1196
    Location:348524
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:451647
    Fez1
  8. NM_001388193.1NP_001375122.1  leucine zipper putative tumor suppressor 3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL121891
    Conserved Domains (2) summary
    COG1196
    Location:318494
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:421617
    Fez1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    3162617..3173549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529408.3XP_011527710.1  leucine zipper putative tumor suppressor 3 isoform X1

    See identical proteins and their annotated locations for XP_011527710.1

    Conserved Domains (2) summary
    COG1196
    Location:348545
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:468668
    Fez1
  2. XM_011529409.3XP_011527711.1  leucine zipper putative tumor suppressor 3 isoform X1

    See identical proteins and their annotated locations for XP_011527711.1

    Conserved Domains (2) summary
    COG1196
    Location:348545
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam06818
    Location:468668
    Fez1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_014731.2: Suppressed sequence

    Description
    NM_014731.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Support Center