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USP6NL USP6 N-terminal like [ Homo sapiens (human) ]

Gene ID: 9712, updated on 23-Nov-2021

Summary

Official Symbol
USP6NLprovided by HGNC
Official Full Name
USP6 N-terminal likeprovided by HGNC
Primary source
HGNC:HGNC:16858
See related
Ensembl:ENSG00000148429 MIM:605405
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNTRE; TRE2NL; USP6NL-IT1
Expression
Broad expression in testis (RPKM 11.0), esophagus (RPKM 10.8) and 24 other tissues See more
Orthologs
NEW
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Genomic context

See USP6NL in Genome Data Viewer
Location:
10p14
Exon count:
23
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (11460510..11611650, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (11495945..11653649, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene CUGBP Elav-like family member 2 Neighboring gene uncharacterized LOC105376409 Neighboring gene CELF2 antisense RNA 1 Neighboring gene uncharacterized LOC105376411 Neighboring gene uncharacterized LOC105376410 Neighboring gene uncharacterized LOC105376413 Neighboring gene USP6NL antisense RNA 1 Neighboring gene uncharacterized LOC105376412 Neighboring gene VISTA enhancer hs1382 Neighboring gene CRISPRi-validated cis-regulatory element chr10.454

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0019

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in trans-Golgi network membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
USP6 N-terminal-like protein
Names
related to the N-terminus of tre

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080491.5NP_001073960.1  USP6 N-terminal-like protein isoform 2

    See identical proteins and their annotated locations for NP_001073960.1

    Status: VALIDATED

    Source sequence(s)
    AL590416
    Consensus CDS
    CCDS44357.1
    UniProtKB/Swiss-Prot
    Q92738
    Related
    ENSP00000277575.5, ENST00000277575.5
    Conserved Domains (1) summary
    smart00164
    Location:114329
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  2. NM_001391959.1NP_001378888.1  USP6 N-terminal-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL590416
    Related
    ENSP00000368539.2, ENST00000379237.6
    Conserved Domains (2) summary
    smart00164
    Location:120335
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    PHA03247
    Location:417746
    PHA03247; large tegument protein UL36; Provisional
  3. NM_001391960.1NP_001378889.1  USP6 N-terminal-like protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL512631, AL590416
    Conserved Domains (2) summary
    smart00164
    Location:48263
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    PHA03247
    Location:345674
    PHA03247; large tegument protein UL36; Provisional
  4. NM_001391961.1NP_001378890.1  USP6 N-terminal-like protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL512631, AL590416
    Conserved Domains (2) summary
    smart00164
    Location:97310
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    PHA03247
    Location:343672
    PHA03247; large tegument protein UL36; Provisional
  5. NM_014688.5NP_055503.1  USP6 N-terminal-like protein isoform 1

    See identical proteins and their annotated locations for NP_055503.1

    Status: VALIDATED

    Source sequence(s)
    AL512631, AL590416
    Consensus CDS
    CCDS53492.1
    UniProtKB/Swiss-Prot
    Q92738
    Related
    ENSP00000476462.1, ENST00000609104.5
    Conserved Domains (2) summary
    smart00164
    Location:97312
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cl26464
    Location:394723
    Atrophin-1; Atrophin-1 family

RNA

  1. NR_125732.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple exons and contains an alternate 3' terminal exon, compared to variant 1. This variant is represented as non-coding because it lacks almost the entire coding region found in variant 1.
    Source sequence(s)
    AA741061, BC010351
    Related
    ENST00000606752.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    11460510..11611650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717542.3XP_006717605.1  USP6 N-terminal-like protein isoform X1

    See identical proteins and their annotated locations for XP_006717605.1

    Conserved Domains (1) summary
    smart00164
    Location:125340
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  2. XM_024448263.1XP_024304031.1  USP6 N-terminal-like protein isoform X3

    Conserved Domains (2) summary
    smart00164
    Location:18233
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    cl26464
    Location:315644
    Atrophin-1; Atrophin-1 family
  3. XM_011519762.2XP_011518064.1  USP6 N-terminal-like protein isoform X1

    See identical proteins and their annotated locations for XP_011518064.1

    Conserved Domains (1) summary
    smart00164
    Location:125340
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  4. XM_011519763.2XP_011518065.1  USP6 N-terminal-like protein isoform X4

    See identical proteins and their annotated locations for XP_011518065.1

    Conserved Domains (1) summary
    smart00164
    Location:1156
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  5. XM_017016972.1XP_016872461.1  USP6 N-terminal-like protein isoform X4

    Conserved Domains (1) summary
    smart00164
    Location:1156
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  6. XM_017016971.1XP_016872460.1  USP6 N-terminal-like protein isoform X2

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