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Tprn taperin [ Mus musculus (house mouse) ]

Gene ID: 97031, updated on 5-Mar-2024

Summary

Official Symbol
Tprnprovided by MGI
Official Full Name
taperinprovided by MGI
Primary source
MGI:MGI:2139535
See related
Ensembl:ENSMUSG00000048707 AllianceGenome:MGI:2139535
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C430004E15Rik
Summary
Predicted to enable phosphatase binding activity. Involved in sensory perception of sound and stereocilium maintenance. Acts upstream of or within auditory receptor cell stereocilium organization. Located in stereocilium base. Is expressed in several structures, including central nervous system; immune system; reproductive system; respiratory system; and submandibular gland. Used to study autosomal recessive nonsyndromic deafness 79. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 79. Orthologous to human TPRN (taperin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 57.5), small intestine adult (RPKM 53.4) and 14 other tissues See more
Orthologs
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Genomic context

See Tprn in Genome Data Viewer
Location:
2 A3; 2 17.11 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25152610..25159898)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25262598..25269886)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ring finger protein 208 Neighboring gene NADPH dependent diflavin oxidoreductase 1 Neighboring gene transmembrane protein 203 Neighboring gene STARR-positive B cell enhancer ABC_E805 Neighboring gene SS nuclear autoantigen 1 Neighboring gene anaphase promoting complex subunit 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2)  1 citation

General gene information

Markers

Clone Names

  • MGC107193

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in auditory receptor cell stereocilium organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within auditory receptor cell stereocilium organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in sensory perception of sound IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
 
involved_in stereocilium maintenance IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in stereocilium maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in stereocilium IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in stereocilium base IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in stereocilium base IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175286.4NP_780495.2  taperin

    See identical proteins and their annotated locations for NP_780495.2

    Status: VALIDATED

    Source sequence(s)
    AI842038, AK082888, AL732309
    Consensus CDS
    CCDS15759.2
    UniProtKB/Swiss-Prot
    A2AI08, Q3TAJ8, Q3TMR8, Q5FWB3, Q7TNG3, Q8BNM5, Q8R1G4
    Related
    ENSMUSP00000109975.4, ENSMUST00000114336.4
    Conserved Domains (2) summary
    pfam13914
    Location:506645
    Phostensin; Phostensin PP1-binding and SH3-binding region
    pfam13916
    Location:889
    Phostensin_N; PP1-regulatory protein, Phostensin N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    25152610..25159898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)