U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TTI1 TELO2 interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 9675, updated on 6-Sep-2022

Summary

Official Symbol
TTI1provided by HGNC
Official Full Name
TELO2 interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:29029
See related
Ensembl:ENSG00000101407 MIM:614425; AllianceGenome:HGNC:29029
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
smg-10; KIAA0406
Summary
Involved in regulation of TOR signaling. Located in cytoplasm. Part of TORC1 complex and TORC2 complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 7.8), thyroid (RPKM 6.4) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See TTI1 in Genome Data Viewer
Location:
20q11.23
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (37983021..38033456, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (39707342..39757800, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (36611423..36661858, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904896 Neighboring gene V-set and transmembrane domain containing 2 like Neighboring gene RN7SK pseudogene 185 Neighboring gene uncharacterized LOC124904898 Neighboring gene regulation of nuclear pre-mRNA domain containing 1B Neighboring gene uncharacterized LOC124904897

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38132, KIAA0406

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of DNA damage checkpoint IC
Inferred by Curator
more info
PubMed 
involved_in protein stabilization IC
Inferred by Curator
more info
PubMed 
involved_in regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of ASTRA complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of TORC1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of TORC2 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of TTT complex IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
TELO2-interacting protein 1 homolog
Names
TEL2-interacting protein 1 homolog
Tel two interacting protein 1
smg-10 homolog, nonsense mediated mRNA decay factor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303457.2NP_001290386.1  TELO2-interacting protein 1 homolog

    See identical proteins and their annotated locations for NP_001290386.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    BC013755, BU684997, DA652320
    Consensus CDS
    CCDS13300.1
    UniProtKB/Swiss-Prot
    O43156, Q9H4K0
    Related
    ENSP00000362546.3, ENST00000373447.8
  2. NM_014657.3NP_055472.1  TELO2-interacting protein 1 homolog

    See identical proteins and their annotated locations for NP_055472.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    BC013121, BU684997, DA652320
    Consensus CDS
    CCDS13300.1
    UniProtKB/Swiss-Prot
    O43156, Q9H4K0
    Related
    ENSP00000362547.2, ENST00000373448.6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    37983021..38033456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440606.1XP_047296562.1  TELO2-interacting protein 1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9H4K0
  2. XM_017028148.3XP_016883637.1  TELO2-interacting protein 1 homolog isoform X2

  3. XM_011529114.3XP_011527416.1  TELO2-interacting protein 1 homolog isoform X3

    See identical proteins and their annotated locations for XP_011527416.1

  4. XM_047440607.1XP_047296563.1  TELO2-interacting protein 1 homolog isoform X3

  5. XM_047440608.1XP_047296564.1  TELO2-interacting protein 1 homolog isoform X3

  6. XM_047440609.1XP_047296565.1  TELO2-interacting protein 1 homolog isoform X4

  7. XM_047440610.1XP_047296566.1  TELO2-interacting protein 1 homolog isoform X4

RNA

  1. XR_001754440.3 RNA Sequence

  2. XR_007067483.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    39707342..39757800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)