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IPO13 importin 13 [ Homo sapiens (human) ]

Gene ID: 9670, updated on 5-Sep-2021

Summary

Official Symbol
IPO13provided by HGNC
Official Full Name
importin 13provided by HGNC
Primary source
HGNC:HGNC:16853
See related
Ensembl:ENSG00000117408 MIM:610411
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LGL2; IMP13; KAP13; RANBP13
Summary
This gene encodes a member of the importin-beta family of nuclear transport proteins. The encoded protein mediates the import of specific cargo proteins from the cytoplasm to the nucleus and is dependent on the Ras-related nuclear protein-GTPase system. The encoded protein is also involved in nuclear export of the eukaryotic translation initiation factor 1A.[provided by RefSeq, Mar 2009]
Expression
Broad expression in testis (RPKM 29.4), brain (RPKM 19.8) and 24 other tissues See more
Orthologs
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Genomic context

See IPO13 in Genome Data Viewer
Location:
1p34.1
Exon count:
21
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (43946852..43968022)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (44412622..44433694)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene artemin Neighboring gene long intergenic non-protein coding RNA 2918 Neighboring gene uncharacterized LOC101929609 Neighboring gene diphthamide biosynthesis 2 Neighboring gene ATPase H+ transporting V0 subunit b

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0724

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
importin-13
Names
Ran binding protein 13
karyopherin 13
late gestation lung 2
ran-binding protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014652.4NP_055467.3  importin-13

    See identical proteins and their annotated locations for NP_055467.3

    Status: REVIEWED

    Source sequence(s)
    AB018267, AL357079, BX116797
    Consensus CDS
    CCDS503.1
    UniProtKB/Swiss-Prot
    O94829
    Related
    ENSP00000361418.3, ENST00000372343.8
    Conserved Domains (5) summary
    smart00913
    Location:45109
    IBN_N; Importin-beta N-terminal domain
    pfam08389
    Location:117263
    Xpo1; Exportin 1-like protein
    pfam18773
    Location:402441
    Importin_rep; Importin 13 repeat
    pfam18786
    Location:584627
    Importin_rep_2; Importin 13 repeat
    pfam18806
    Location:826900
    Importin_rep_3; Importin 13 repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    43946852..43968022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451069.1XP_024306837.1  importin-13 isoform X1

  2. XM_024451070.1XP_024306838.1  importin-13 isoform X1

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