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MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 [ Homo sapiens (human) ]

Gene ID: 9645, updated on 1-Jun-2020

Summary

Official Symbol
MICAL2provided by HGNC
Official Full Name
microtubule associated monooxygenase, calponin and LIM domain containing 2provided by HGNC
Primary source
HGNC:HGNC:24693
See related
Ensembl:ENSG00000133816 MIM:608881
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MICAL-2; MICAL2PV1; MICAL2PV2
Summary
The protein encoded by this gene is a monooxygenase that enhances depolymerization of F-actin and is therefore involved in cytoskeletal dynamics. The encoded protein is a regulator of the SRF signaling pathway. Increased expression of this gene has been associated with cancer progression and metastasis. [provided by RefSeq, Oct 2016]
Expression
Broad expression in testis (RPKM 23.1), colon (RPKM 17.9) and 24 other tissues See more
Orthologs

Genomic context

See MICAL2 in Genome Data Viewer
Location:
11p15.3
Exon count:
29
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (12110576..12263790)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (12132138..12285335)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene dickkopf WNT signaling pathway inhibitor 3 Neighboring gene long intergenic non-protein coding RNA 2547 Neighboring gene GATA motif-containing MPRA enhancer 176/177 Neighboring gene uncharacterized LOC107984312 Neighboring gene microRNA 6124 Neighboring gene Sharpr-MPRA regulatory region 12121 Neighboring gene MICAL C-terminal like Neighboring gene Sharpr-MPRA regulatory region 4146

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21533, FLJ22463, FLJ33231, FLJ43564, FLJ43797, KIAA0750, DKFZp686H2469, DKFZp686H03148

Gene Ontology Provided by GOA

Function Evidence Code Pubs
FAD binding ISS
Inferred from Sequence or Structural Similarity
more info
 
NAD(P)H oxidase activity IEA
Inferred from Electronic Annotation
more info
 
NADPH:sulfur oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
actin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
actin filament depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
heart looping ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription via serum response element binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
sulfur oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
filamentous actin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
[F-actin]-monooxygenase MICAL2
Names
[F-actin]-methionine sulfoxide oxidase MICAL2
flavoprotein oxidoreductase MICAL2
microtubule associated monoxygenase, calponin and LIM domain containing 2
molecule interacting with CasL protein 2
protein-methionine sulfoxide oxidase MICAL2
NP_001269592.1
NP_001269593.1
NP_001269594.1
NP_001269595.1
NP_001269596.1
NP_001269597.1
NP_001333221.1
NP_001333222.1
NP_001333223.1
NP_001333224.1
NP_001333225.1
NP_001333226.1
NP_001333227.1
NP_001333228.1
NP_055447.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051801.1 RefSeqGene

    Range
    5015..158210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001282663.2NP_001269592.1  [F-actin]-monooxygenase MICAL2 isoform a

    See identical proteins and their annotated locations for NP_001269592.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 8 all encode isoform a.
    Source sequence(s)
    AB018293, AK294845, DA246062
    Consensus CDS
    CCDS7809.1
    UniProtKB/Swiss-Prot
    O94851
    Conserved Domains (4) summary
    cd09439
    Location:10021056
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam00307
    Location:522617
    CH; Calponin homology (CH) domain
    pfam01494
    Location:87274
    FAD_binding_3; FAD binding domain
    cl21454
    Location:78121
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_001282664.1NP_001269593.1  [F-actin]-monooxygenase MICAL2 isoform b

    See identical proteins and their annotated locations for NP_001269593.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a portion of the 5' UTR, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 3 and 9-15 all encode the same isoform (b).
    Source sequence(s)
    AK294845, AL046982, BC044577, DA246062
    Consensus CDS
    CCDS60726.1
    UniProtKB/Swiss-Prot
    O94851
    Conserved Domains (4) summary
    cd09439
    Location:9811035
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam00307
    Location:522617
    CH; Calponin homology (CH) domain
    pfam01494
    Location:87274
    FAD_binding_3; FAD binding domain
    cl21454
    Location:78121
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. NM_001282665.1NP_001269594.1  [F-actin]-monooxygenase MICAL2 isoform c

    See identical proteins and their annotated locations for NP_001269594.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks a portion of the 5' UTR, lacks four exons that result in the loss of an in-frame segment in the central coding region, and differs in the 3' UTR, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AK294845, AK302893, AL046982, BC048206, BG939697
    Consensus CDS
    CCDS60727.1
    UniProtKB/Swiss-Prot
    O94851
    Related
    ENSP00000433965.1, ENST00000527546.5
    Conserved Domains (4) summary
    cd09439
    Location:812866
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam00307
    Location:522617
    CH; Calponin homology (CH) domain
    pfam01494
    Location:87274
    FAD_binding_3; FAD binding domain
    cl21454
    Location:78121
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. NM_001282666.1NP_001269595.1  [F-actin]-monooxygenase MICAL2 isoform d

    See identical proteins and their annotated locations for NP_001269595.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks a portion of the 5' UTR, lacks four exons that result in the loss of an in-frame segment in the central coding region, and has multiple differences in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AB110785, AK294845, AK302893, AL046982, BC048206, BG939697, BX641163
    Consensus CDS
    CCDS60728.1
    UniProtKB/Swiss-Prot
    O94851
    Conserved Domains (4) summary
    cd09439
    Location:776830
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam00307
    Location:522617
    CH; Calponin homology (CH) domain
    pfam01494
    Location:87274
    FAD_binding_3; FAD binding domain
    cl21454
    Location:78121
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  5. NM_001282667.1NP_001269596.1  [F-actin]-monooxygenase MICAL2 isoform e

    See identical proteins and their annotated locations for NP_001269596.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks a portion of the 5' UTR, lacks six exons that result in the loss of an in-frame segment in the central coding region, and has multiple differences in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AB110786, AK294845, AK302893, AL046982, BC048206, BG939697, BX641163
    UniProtKB/Swiss-Prot
    O94851
    Related
    ENSP00000499778.1, ENST00000528931.5
    Conserved Domains (4) summary
    cd09439
    Location:755809
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam00307
    Location:522617
    CH; Calponin homology (CH) domain
    pfam01494
    Location:87274
    FAD_binding_3; FAD binding domain
    cl21454
    Location:78121
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  6. NM_001282668.1NP_001269597.1  [F-actin]-monooxygenase MICAL2 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site in the 5' UTR, and lacks several 3' exons but contains an alternate 3' terminal exon, compared to variant 1. The encoded isoform (f) has a distinct C-terminus and is significantly shorter than isoform a.
    Source sequence(s)
    BC015755, DA246062
    Related
    ENST00000531732.5
    Conserved Domains (1) summary
    cl21454
    Location:78121
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  7. NM_001346292.2NP_001333221.1  [F-actin]-monooxygenase MICAL2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 1 and 2, encodes isoform a.
    Source sequence(s)
    AC025106, AC079329
    Consensus CDS
    CCDS7809.1
    UniProtKB/Swiss-Prot
    O94851
  8. NM_001346293.2NP_001333222.1  [F-actin]-monooxygenase MICAL2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 3 and 10-15, encodes isoform b.
    Source sequence(s)
    AC025106, AC079329
    Consensus CDS
    CCDS60726.1
    UniProtKB/Swiss-Prot
    O94851
  9. NM_001346294.2NP_001333223.1  [F-actin]-monooxygenase MICAL2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 3, 9, and 11-15, encodes isoform b.
    Source sequence(s)
    AC025106, AC079329
    Consensus CDS
    CCDS60726.1
    UniProtKB/Swiss-Prot
    O94851
  10. NM_001346295.2NP_001333224.1  [F-actin]-monooxygenase MICAL2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 3, 9-10, and 12-15, encodes isoform b.
    Source sequence(s)
    AC025106, AC079329
    Consensus CDS
    CCDS60726.1
    UniProtKB/Swiss-Prot
    O94851
  11. NM_001346296.2NP_001333225.1  [F-actin]-monooxygenase MICAL2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 3, 9-11, and 13-15, encodes isoform b.
    Source sequence(s)
    AC025106, AC079329
    Consensus CDS
    CCDS60726.1
    UniProtKB/Swiss-Prot
    O94851
  12. NM_001346297.2NP_001333226.1  [F-actin]-monooxygenase MICAL2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 3, 9-12, and 14-15, encodes isoform b.
    Source sequence(s)
    AC025106, AC079329
    Consensus CDS
    CCDS60726.1
    UniProtKB/Swiss-Prot
    O94851
  13. NM_001346298.2NP_001333227.1  [F-actin]-monooxygenase MICAL2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 3, 9-13, and 15, encodes isoform b.
    Source sequence(s)
    AC025106, AC079329
    Consensus CDS
    CCDS60726.1
    UniProtKB/Swiss-Prot
    O94851
  14. NM_001346299.2NP_001333228.1  [F-actin]-monooxygenase MICAL2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 3 and 9-14, encodes isoform b.
    Source sequence(s)
    AC025106, AC079329
    Consensus CDS
    CCDS60726.1
    UniProtKB/Swiss-Prot
    O94851
  15. NM_014632.4NP_055447.1  [F-actin]-monooxygenase MICAL2 isoform a

    See identical proteins and their annotated locations for NP_055447.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 8 all encode isoform a.
    Source sequence(s)
    AK294845, BC044577, DA246062
    Consensus CDS
    CCDS7809.1
    UniProtKB/Swiss-Prot
    O94851
    Related
    ENSP00000256194.4, ENST00000256194.8
    Conserved Domains (4) summary
    cd09439
    Location:10021056
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam00307
    Location:522617
    CH; Calponin homology (CH) domain
    pfam01494
    Location:87274
    FAD_binding_3; FAD binding domain
    cl21454
    Location:78121
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. NR_144415.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025106, AC079329
  2. NR_144416.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025106, AC079329
  3. NR_144417.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025106, AC079329
  4. NR_144418.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025106, AC079329
  5. NR_144419.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025106, AC079329
  6. NR_144420.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025106, AC079329

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    12110576..12263790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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