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MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 [ Homo sapiens (human) ]

Gene ID: 9645, updated on 9-Dec-2024

Summary

Official Symbol
MICAL2provided by HGNC
Official Full Name
microtubule associated monooxygenase, calponin and LIM domain containing 2provided by HGNC
Primary source
HGNC:HGNC:24693
See related
Ensembl:ENSG00000133816 MIM:608881; AllianceGenome:HGNC:24693
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MICAL-2; MICALCL; Ebitein1; mical-cL; MICAL2PV1; MICAL2PV2
Summary
The protein encoded by this gene is a monooxygenase that enhances depolymerization of F-actin and is therefore involved in cytoskeletal dynamics. The encoded protein is a regulator of the SRF signaling pathway. Increased expression of this gene has been associated with cancer progression and metastasis. [provided by RefSeq, Oct 2016]
Expression
Broad expression in testis (RPKM 23.1), colon (RPKM 17.9) and 24 other tissues See more
Orthologs
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Genomic context

See MICAL2 in Genome Data Viewer
Location:
11p15.3
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (12110590..12362140)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (12202447..12454129)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (12132137..12383687)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2547 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:12087483-12088682 Neighboring gene Sharpr-MPRA regulatory region 886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:12114457-12114957 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:12125283-12125783 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:12132043-12132746 Neighboring gene long intergenic non-protein coding RNA 2989 Neighboring gene GATA motif-containing MPRA enhancer 176/177 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:12158230-12158730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:12160461-12161004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:12161005-12161546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:12184971-12185470 Neighboring gene Sharpr-MPRA regulatory region 10887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4462 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:12200287-12201161 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:12203881-12204381 Neighboring gene Sharpr-MPRA regulatory region 12121 Neighboring gene microRNA 6124 Neighboring gene uncharacterized LOC124902634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:12238418-12238918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:12238919-12239419 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:12263505-12264029 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:12352017-12352518 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:12387753-12388325 Neighboring gene parvin alpha Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:12474119-12474620 Neighboring gene Sharpr-MPRA regulatory region 15612/8581 Neighboring gene Sharpr-MPRA regulatory region 1666 Neighboring gene uncharacterized LOC105376556 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:12658187-12658688 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:12658689-12659188

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ14966, FLJ21533, FLJ22463, FLJ33231, FLJ41677, FLJ43564, FLJ43797, KIAA0750, MGC195878, DKFZp686H2469, DKFZp686H03148

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables F-actin monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables FAD binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables NAD(P)H oxidase H2O2-forming activity IEA
Inferred from Electronic Annotation
more info
 
enables actin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables mitogen-activated protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin filament depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in heart looping ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sulfur oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in actin filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
[F-actin]-monooxygenase MICAL2
Names
ERK2-binding testicular protein 1
MICAL C-terminal like
MICAL C-terminal-like protein
[F-actin]-methionine sulfoxide oxidase MICAL2
ebitein-1
flavoprotein oxidoreductase MICAL2
microtubule associated monoxygenase, calponin and LIM domain containing 2
molecule interacting with CasL protein 2
protein-methionine sulfoxide oxidase MICAL2
NP_001269592.1
NP_001269593.1
NP_001269594.1
NP_001269595.1
NP_001269596.1
NP_001269597.1
NP_001333221.1
NP_001333222.1
NP_001333223.1
NP_001333224.1
NP_001333225.1
NP_001333226.1
NP_001333227.1
NP_001333228.1
NP_001380866.1
NP_055447.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051801.2 RefSeqGene

    Range
    5002..158197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001282663.2NP_001269592.1  [F-actin]-monooxygenase MICAL2 isoform a

    See identical proteins and their annotated locations for NP_001269592.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 8 all encode isoform a.
    Source sequence(s)
    AB018293, AK294845, DA246062
    Consensus CDS
    CCDS7809.1
    UniProtKB/Swiss-Prot
    O94851
    Related
    ENSP00000507067.1, ENST00000683283.1
    Conserved Domains (4) summary
    cd09439
    Location:10021056
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam00307
    Location:522617
    CH; Calponin homology (CH) domain
    pfam01494
    Location:87274
    FAD_binding_3; FAD binding domain
    cl21454
    Location:78121
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_001282664.1NP_001269593.1  [F-actin]-monooxygenase MICAL2 isoform b

    See identical proteins and their annotated locations for NP_001269593.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a portion of the 5' UTR, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 3 and 9-15 all encode the same isoform (b).
    Source sequence(s)
    AK294845, AL046982, BC044577, DA246062
    Consensus CDS
    CCDS60726.1
    UniProtKB/Swiss-Prot
    O94851
    Related
    ENSP00000502351.1, ENST00000675839.1
    Conserved Domains (4) summary
    cd09439
    Location:9811035
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam00307
    Location:522617
    CH; Calponin homology (CH) domain
    pfam01494
    Location:87274
    FAD_binding_3; FAD binding domain
    cl21454
    Location:78121
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. NM_001282665.1NP_001269594.1  [F-actin]-monooxygenase MICAL2 isoform c

    See identical proteins and their annotated locations for NP_001269594.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks a portion of the 5' UTR, lacks four exons that result in the loss of an in-frame segment in the central coding region, and differs in the 3' UTR, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AK294845, AK302893, AL046982, BC048206, BG939697
    Consensus CDS
    CCDS60727.1
    UniProtKB/Swiss-Prot
    O94851
    Related
    ENSP00000433965.1, ENST00000527546.5
    Conserved Domains (4) summary
    cd09439
    Location:812866
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam00307
    Location:522617
    CH; Calponin homology (CH) domain
    pfam01494
    Location:87274
    FAD_binding_3; FAD binding domain
    cl21454
    Location:78121
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. NM_001282666.1NP_001269595.1  [F-actin]-monooxygenase MICAL2 isoform d

    See identical proteins and their annotated locations for NP_001269595.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks a portion of the 5' UTR, lacks four exons that result in the loss of an in-frame segment in the central coding region, and has multiple differences in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AB110785, AK294845, AK302893, AL046982, BC048206, BG939697, BX641163
    UniProtKB/Swiss-Prot
    O94851
    Related
    ENSP00000516723.1, ENST00000707072.1
    Conserved Domains (4) summary
    cd09439
    Location:776830
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam00307
    Location:522617
    CH; Calponin homology (CH) domain
    pfam01494
    Location:87274
    FAD_binding_3; FAD binding domain
    cl21454
    Location:78121
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  5. NM_001282667.1NP_001269596.1  [F-actin]-monooxygenase MICAL2 isoform e

    See identical proteins and their annotated locations for NP_001269596.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks a portion of the 5' UTR, lacks six exons that result in the loss of an in-frame segment in the central coding region, and has multiple differences in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AB110786, AK294845, AK302893, AL046982, BC048206, BG939697, BX641163
    Consensus CDS
    CCDS91443.1
    UniProtKB/Swiss-Prot
    O94851
    Related
    ENSP00000499778.1, ENST00000528931.5
    Conserved Domains (4) summary
    cd09439
    Location:755809
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam00307
    Location:522617
    CH; Calponin homology (CH) domain
    pfam01494
    Location:87274
    FAD_binding_3; FAD binding domain
    cl21454
    Location:78121
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  6. NM_001282668.2NP_001269597.1  [F-actin]-monooxygenase MICAL2 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site in the 5' UTR, and lacks several 3' exons but contains an alternate 3' terminal exon, compared to variant 1. The encoded isoform (f) has a distinct C-terminus and is significantly shorter than isoform a.
    Source sequence(s)
    BC015755, DA246062
    Related
    ENST00000531732.5
    Conserved Domains (1) summary
    pfam01494
    Location:87141
    FAD_binding_3; FAD binding domain
  7. NM_001346292.2NP_001333221.1  [F-actin]-monooxygenase MICAL2 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 1 and 2, encodes isoform a.
    Source sequence(s)
    AC025106, AC079329
    Consensus CDS
    CCDS7809.1
    UniProtKB/Swiss-Prot
    O94851
  8. NM_001346293.2NP_001333222.1  [F-actin]-monooxygenase MICAL2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 3 and 10-15, encodes isoform b.
    Source sequence(s)
    AC025106, AC079329
    Consensus CDS
    CCDS60726.1
    UniProtKB/Swiss-Prot
    O94851
  9. NM_001346294.2NP_001333223.1  [F-actin]-monooxygenase MICAL2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 3, 9, and 11-15, encodes isoform b.
    Source sequence(s)
    AC025106, AC079329
    Consensus CDS
    CCDS60726.1
    UniProtKB/Swiss-Prot
    O94851
  10. NM_001346295.2NP_001333224.1  [F-actin]-monooxygenase MICAL2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 3, 9-10, and 12-15, encodes isoform b.
    Source sequence(s)
    AC025106, AC079329
    Consensus CDS
    CCDS60726.1
    UniProtKB/Swiss-Prot
    O94851
  11. NM_001346296.2NP_001333225.1  [F-actin]-monooxygenase MICAL2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 3, 9-11, and 13-15, encodes isoform b.
    Source sequence(s)
    AC025106, AC079329
    Consensus CDS
    CCDS60726.1
    UniProtKB/Swiss-Prot
    O94851
  12. NM_001346297.2NP_001333226.1  [F-actin]-monooxygenase MICAL2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 3, 9-12, and 14-15, encodes isoform b.
    Source sequence(s)
    AC025106, AC079329
    Consensus CDS
    CCDS60726.1
    UniProtKB/Swiss-Prot
    O94851
  13. NM_001346298.2NP_001333227.1  [F-actin]-monooxygenase MICAL2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 3, 9-13, and 15, encodes isoform b.
    Source sequence(s)
    AC025106, AC079329
    Consensus CDS
    CCDS60726.1
    UniProtKB/Swiss-Prot
    O94851
  14. NM_001346299.2NP_001333228.1  [F-actin]-monooxygenase MICAL2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 3 and 9-14, encodes isoform b.
    Source sequence(s)
    AC025106, AC079329
    Consensus CDS
    CCDS60726.1
    UniProtKB/Swiss-Prot
    O94851
  15. NM_001393937.1NP_001380866.1  [F-actin]-monooxygenase MICAL2 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC025106, AC025300, AC079329
    Consensus CDS
    CCDS91442.1
    UniProtKB/Swiss-Prot
    A0A2R8YFA9, B4DGZ0, B7Z849, D3DQW5, G3XAC8, O94851, Q5KTR3, Q5KTR4, Q6ZW33, Q7RTP7, Q7Z3A8, Q96JU6
    Related
    ENSP00000494982.1, ENST00000646065.1
    Conserved Domains (6) summary
    cd09439
    Location:10021056
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    smart00945
    Location:16281718
    ProQ; ProQ/FINO family
    smart00033
    Location:522617
    CH; Calponin homology domain
    PHA03247
    Location:10871624
    PHA03247; large tegument protein UL36; Provisional
    cl30692
    Location:87226
    UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
    pfam17380
    Location:17731944
    DUF5401; Family of unknown function (DUF5401)
  16. NM_014632.4NP_055447.1  [F-actin]-monooxygenase MICAL2 isoform a

    See identical proteins and their annotated locations for NP_055447.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 8 all encode isoform a.
    Source sequence(s)
    AK294845, BC044577, DA246062
    Consensus CDS
    CCDS7809.1
    UniProtKB/Swiss-Prot
    O94851
    Related
    ENSP00000256194.4, ENST00000256194.8
    Conserved Domains (4) summary
    cd09439
    Location:10021056
    LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
    pfam00307
    Location:522617
    CH; Calponin homology (CH) domain
    pfam01494
    Location:87274
    FAD_binding_3; FAD binding domain
    cl21454
    Location:78121
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. NR_144415.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025106, AC079329
  2. NR_144416.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025106, AC079329
  3. NR_144417.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025106, AC079329
  4. NR_144418.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025106, AC079329
  5. NR_144419.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025106, AC079329
  6. NR_144420.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025106, AC079329

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    12110590..12362140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    12202447..12454129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_032867.4: Suppressed sequence

    Description
    NM_032867.4: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.