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SNCAIP synuclein alpha interacting protein [ Homo sapiens (human) ]

Gene ID: 9627, updated on 16-Dec-2023

Summary

Official Symbol
SNCAIPprovided by HGNC
Official Full Name
synuclein alpha interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:11139
See related
Ensembl:ENSG00000064692 MIM:603779; AllianceGenome:HGNC:11139
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Sph1; SYPH1
Summary
This gene encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. A mutation in this gene has been associated with Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Biased expression in ovary (RPKM 8.3), endometrium (RPKM 6.2) and 11 other tissues See more
Orthologs
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Genomic context

See SNCAIP in Genome Data Viewer
Location:
5q23.2
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (122311353..122464219)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (122828188..122981079)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (121647386..121799914)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ZNF474 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:121464631-121465830 Neighboring gene zinc finger protein 474 Neighboring gene zinc finger protein 475 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:121602368-121603567 Neighboring gene NANOG hESC enhancer GRCh37_chr5:121632489-121632990 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:121705022-121705522 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:121718337-121718951 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:121718952-121719565 Neighboring gene ancient vomeronasal 1 receptor pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22995 Neighboring gene uncharacterized LOC107986446 Neighboring gene uncharacterized LOC153163 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:121809862-121810690 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:121850537-121851074 Neighboring gene uncharacterized LOC105379151 Neighboring gene uncharacterized LOC101927357

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC39814

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in neuronal cell body NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in presynaptic membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in synaptic vesicle TAS
Traceable Author Statement
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011486.2 RefSeqGene

    Range
    5113..157095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242935.3NP_001229864.1  synphilin-1 isoform 1A

    See identical proteins and their annotated locations for NP_001229864.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1A) differs in the 5' UTR, lacks an alternate exon in the 5' coding region that results in translation initiation from a downstream start codon in a different reading frame, and lacks two alternate exons in the central coding region, compared to variant 2. The encoded isoform (1A) has a distinct N-terminus and is shorter than isoform 2.
    Source sequence(s)
    BC040552, DQ227317, N21998
    UniProtKB/TrEMBL
    Q9NVG1
    Conserved Domains (4) summary
    cd00204
    Location:28144
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:28121
    Ank_2; Ankyrin repeats (3 copies)
    pfam16700
    Location:146189
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
    sd00045
    Location:5688
    ANK; ANK repeat [structural motif]
  2. NM_001308100.2NP_001295029.1  synphilin-1 isoform 2

    See identical proteins and their annotated locations for NP_001295029.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
    Source sequence(s)
    AF076929, BC040552, N21998
    Consensus CDS
    CCDS78054.1
    UniProtKB/TrEMBL
    D6R9G8
    Related
    ENSP00000261367.7, ENST00000261367.11
    Conserved Domains (5) summary
    cd00204
    Location:392557
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:438534
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:397452
    Ank_4; Ankyrin repeats (many copies)
    pfam16700
    Location:559602
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
    sd00045
    Location:396429
    ANK; ANK repeat [structural motif]
  3. NM_001308105.1NP_001295034.1  synphilin-1 isoform B

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) lacks an alternate in-frame exon in both the 5' and central coding regions, and also lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 2. The encoded isoform (B) has a distinct C-terminus and is shorter than isoform 2. This variant lacks 5'-complete transcript support and thus its 5' UTR is incomplete.
    Source sequence(s)
    AB110789, AK299687, AK304646, AK310835, BC040552, N21998
    UniProtKB/TrEMBL
    D6R9G8
    Related
    ENSP00000422106.2, ENST00000509154.6
    Conserved Domains (4) summary
    cd00204
    Location:335450
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:335427
    Ank_2; Ankyrin repeats (3 copies)
    pfam16700
    Location:452495
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
    sd00045
    Location:362394
    ANK; ANK repeat [structural motif]
  4. NM_001308106.1NP_001295035.1  synphilin-1 isoform D

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) lacks two alternate exons in the 5' coding region that result in translation initiation from a downstream start codon in a different reading frame, and it also lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 2. The encoded isoform (D) has distinct N- and C-termini and is shorter than isoform 2. This variant lacks 5'-complete transcript support and thus its 5' UTR is incomplete.
    Source sequence(s)
    AB110791, AK299687, AK304646, BC040552, N21998
    UniProtKB/TrEMBL
    B7Z995, D6RHZ0
    Conserved Domains (4) summary
    cd00204
    Location:26142
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:26119
    Ank_2; Ankyrin repeats (3 copies)
    pfam16700
    Location:144187
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
    sd00045
    Location:5486
    ANK; ANK repeat [structural motif]
  5. NM_001308107.2NP_001295036.1  synphilin-1 isoform E

    Status: REVIEWED

    Description
    Transcript Variant: This variant (e) differs in the 5' UTR, lacks an alternate exon in the 5' coding region that results in translation initiation from a downstream start codon in a different reading frame, lacks two alternate exons in the central coding region, and also lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 2. The encoded isoform (E) has distinct N- and C-termini and is shorter than isoform 2.
    Source sequence(s)
    AI702863, AK304646, BC033743, BC040552, N21998
    UniProtKB/TrEMBL
    B7Z995, D6RHZ0
    Conserved Domains (3) summary
    sd00045
    Location:5688
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:28121
    Ank_2; Ankyrin repeats (3 copies)
    pfam16700
    Location:146189
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
  6. NM_001308108.1NP_001295037.1  synphilin-1 isoform F

    Status: REVIEWED

    Description
    Transcript Variant: This variant (f) lacks an alternate exon in the 5' coding region that results in translation initiation from a downstream start codon in a different reading frame, lacks an alternate exon in the central coding region, and also lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 2. The encoded isoform (F) has distinct N- and C-termini and is shorter than isoform 2. This variant lacks 5'-complete transcript support and thus its 5' UTR is incomplete.
    Source sequence(s)
    AB110793, AK299687, AK304646, BC040552, N21998
    UniProtKB/TrEMBL
    B7Z995, D6RHZ0
    Conserved Domains (5) summary
    cd00204
    Location:39204
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:85181
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:4499
    Ank_4; Ankyrin repeats (many copies)
    pfam16700
    Location:206249
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
    sd00045
    Location:4376
    ANK; ANK repeat [structural motif]
  7. NM_001308109.2NP_001295038.1  synphilin-1 isoform G

    Status: REVIEWED

    Description
    Transcript Variant: This variant (g) differs in the 5' UTR, lacks an alternate exon in the 5' coding region that results in translation initiation from a downstream start codon in a different reading frame, lacks three alternate exons in the central coding region, and also lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 2. The encoded isoform (G) has distinct N- and C-termini and is shorter than isoform 2.
    Source sequence(s)
    AK304646, BC040552, N21998
    UniProtKB/TrEMBL
    B7Z995, D6RHZ0
    Conserved Domains (4) summary
    sd00045
    Location:5283
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:53106
    Ank_4; Ankyrin repeats (many copies)
    pfam16700
    Location:108151
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
    cl39094
    Location:383
    Ank_2; Ankyrin repeats (3 copies)
  8. NM_005460.4NP_005451.2  synphilin-1 isoform 1

    See identical proteins and their annotated locations for NP_005451.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as variant a) differs in the 5' UTR, lacks an alternate in-frame exon in the 5' coding region, and lacks an exon that results in a frameshift in the 3' coding region, compared to variant 2. The encoded isoform (1) has a distinct C-terminus and is shorter than isoform 2.
    Source sequence(s)
    AF076929, AI702863, BC040552, N21998
    Consensus CDS
    CCDS4131.1
    UniProtKB/Swiss-Prot
    D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5
    UniProtKB/TrEMBL
    D6R9G8
    Related
    ENSP00000261368.8, ENST00000261368.13
    Conserved Domains (3) summary
    cd00204
    Location:345510
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:349382
    ANK; ANK repeat [structural motif]
    pfam16700
    Location:512555
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain

RNA

  1. NR_131761.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (c) includes two additional exons in the central region but lacks an alternate exon in the 3' region, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This variant lacks 5'-complete transcript support and thus its 5' end is incomplete.
    Source sequence(s)
    AB110790, AK299687, AK304646, BC040552, N21998
  2. NR_131762.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and lacks five internal exons but includes an additional internal exon, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK299687, AK304646, BC040552, N21998
    Related
    ENST00000510658.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    122311353..122464219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714734.3XP_006714797.1  synphilin-1 isoform X4

    See identical proteins and their annotated locations for XP_006714797.1

    UniProtKB/TrEMBL
    D6R9G8
    Conserved Domains (3) summary
    cd00204
    Location:345510
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:349382
    ANK; ANK repeat [structural motif]
    pfam16700
    Location:512555
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
  2. XM_047417925.1XP_047273881.1  synphilin-1 isoform X8

    UniProtKB/Swiss-Prot
    D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5
    UniProtKB/TrEMBL
    D6R9G8
  3. XM_047417932.1XP_047273888.1  synphilin-1 isoform X14

    UniProtKB/TrEMBL
    B7Z995, D6RHZ0
  4. XM_024446267.2XP_024302035.1  synphilin-1 isoform X8

    UniProtKB/Swiss-Prot
    D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5
    UniProtKB/TrEMBL
    D6R9G8
    Conserved Domains (3) summary
    cd00204
    Location:345510
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:349382
    ANK; ANK repeat [structural motif]
    pfam16700
    Location:512555
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
  5. XM_024446266.2XP_024302034.1  synphilin-1 isoform X4

    UniProtKB/TrEMBL
    D6R9G8
    Conserved Domains (3) summary
    cd00204
    Location:345510
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:349382
    ANK; ANK repeat [structural motif]
    pfam16700
    Location:512555
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
  6. XM_047417927.1XP_047273883.1  synphilin-1 isoform X8

    UniProtKB/Swiss-Prot
    D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5
    UniProtKB/TrEMBL
    D6R9G8
  7. XM_011543738.3XP_011542040.1  synphilin-1 isoform X1

    See identical proteins and their annotated locations for XP_011542040.1

    UniProtKB/TrEMBL
    D6R9G8
    Conserved Domains (5) summary
    cd00204
    Location:392557
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:438534
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:397452
    Ank_4; Ankyrin repeats (many copies)
    pfam16700
    Location:559602
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
    sd00045
    Location:396429
    ANK; ANK repeat [structural motif]
  8. XM_047417915.1XP_047273871.1  synphilin-1 isoform X4

    UniProtKB/TrEMBL
    D6R9G8
  9. XM_017010083.2XP_016865572.1  synphilin-1 isoform X9

    UniProtKB/TrEMBL
    Q9NVG1
    Conserved Domains (4) summary
    cd00204
    Location:34150
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:34127
    Ank_2; Ankyrin repeats (3 copies)
    pfam16700
    Location:152195
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
    sd00045
    Location:6294
    ANK; ANK repeat [structural motif]
  10. XM_024446269.2XP_024302037.1  synphilin-1 isoform X14

    UniProtKB/TrEMBL
    B7Z995, D6RHZ0
    Conserved Domains (3) summary
    cd00204
    Location:34150
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:6294
    ANK; ANK repeat [structural motif]
    pfam16700
    Location:152195
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
  11. XM_047417911.1XP_047273867.1  synphilin-1 isoform X1

    UniProtKB/TrEMBL
    D6R9G8
  12. XM_047417917.1XP_047273873.1  synphilin-1 isoform X5

    UniProtKB/TrEMBL
    D6R9G8
  13. XM_005272139.2XP_005272196.1  synphilin-1 isoform X4

    See identical proteins and their annotated locations for XP_005272196.1

    UniProtKB/TrEMBL
    D6R9G8
    Conserved Domains (3) summary
    cd00204
    Location:345510
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:349382
    ANK; ANK repeat [structural motif]
    pfam16700
    Location:512555
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
  14. XM_047417923.1XP_047273879.1  synphilin-1 isoform X8

    UniProtKB/Swiss-Prot
    D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5
    UniProtKB/TrEMBL
    D6R9G8
  15. XM_011543739.2XP_011542041.1  synphilin-1 isoform X1

    See identical proteins and their annotated locations for XP_011542041.1

    UniProtKB/TrEMBL
    D6R9G8
    Conserved Domains (5) summary
    cd00204
    Location:392557
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:438534
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:397452
    Ank_4; Ankyrin repeats (many copies)
    pfam16700
    Location:559602
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
    sd00045
    Location:396429
    ANK; ANK repeat [structural motif]
  16. XM_047417914.1XP_047273870.1  synphilin-1 isoform X4

    UniProtKB/TrEMBL
    D6R9G8
  17. XM_024446268.2XP_024302036.1  synphilin-1 isoform X8

    UniProtKB/Swiss-Prot
    D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5
    UniProtKB/TrEMBL
    D6R9G8
    Conserved Domains (3) summary
    cd00204
    Location:345510
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:349382
    ANK; ANK repeat [structural motif]
    pfam16700
    Location:512555
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
  18. XM_011543743.3XP_011542045.1  synphilin-1 isoform X1

    See identical proteins and their annotated locations for XP_011542045.1

    UniProtKB/TrEMBL
    D6R9G8
    Conserved Domains (5) summary
    cd00204
    Location:392557
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:438534
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:397452
    Ank_4; Ankyrin repeats (many copies)
    pfam16700
    Location:559602
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
    sd00045
    Location:396429
    ANK; ANK repeat [structural motif]
  19. XM_011543745.2XP_011542047.1  synphilin-1 isoform X4

    See identical proteins and their annotated locations for XP_011542047.1

    UniProtKB/TrEMBL
    D6R9G8
    Conserved Domains (3) summary
    cd00204
    Location:345510
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:349382
    ANK; ANK repeat [structural motif]
    pfam16700
    Location:512555
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
  20. XM_017010082.2XP_016865571.1  synphilin-1 isoform X8

    UniProtKB/Swiss-Prot
    D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5
    UniProtKB/TrEMBL
    D6R9G8
    Conserved Domains (3) summary
    cd00204
    Location:345510
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:349382
    ANK; ANK repeat [structural motif]
    pfam16700
    Location:512555
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
  21. XM_011543749.3XP_011542051.1  synphilin-1 isoform X9

    UniProtKB/TrEMBL
    Q9NVG1
    Conserved Domains (4) summary
    cd00204
    Location:34150
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:34127
    Ank_2; Ankyrin repeats (3 copies)
    pfam16700
    Location:152195
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
    sd00045
    Location:6294
    ANK; ANK repeat [structural motif]
  22. XM_011543737.3XP_011542039.1  synphilin-1 isoform X1

    See identical proteins and their annotated locations for XP_011542039.1

    UniProtKB/TrEMBL
    D6R9G8
    Conserved Domains (5) summary
    cd00204
    Location:392557
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:438534
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:397452
    Ank_4; Ankyrin repeats (many copies)
    pfam16700
    Location:559602
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
    sd00045
    Location:396429
    ANK; ANK repeat [structural motif]
  23. XM_017010081.2XP_016865570.1  synphilin-1 isoform X5

    UniProtKB/TrEMBL
    D6R9G8
    Conserved Domains (5) summary
    cd00204
    Location:392557
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:438534
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:397452
    Ank_4; Ankyrin repeats (many copies)
    pfam16700
    Location:559602
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
    sd00045
    Location:396429
    ANK; ANK repeat [structural motif]
  24. XM_005272138.5XP_005272195.1  synphilin-1 isoform X4

    See identical proteins and their annotated locations for XP_005272195.1

    UniProtKB/TrEMBL
    D6R9G8
    Conserved Domains (3) summary
    cd00204
    Location:345510
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:349382
    ANK; ANK repeat [structural motif]
    pfam16700
    Location:512555
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
  25. XM_017010080.2XP_016865569.1  synphilin-1 isoform X3

    UniProtKB/TrEMBL
    D6R9G8
    Conserved Domains (5) summary
    cd00204
    Location:392557
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:438534
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:397452
    Ank_4; Ankyrin repeats (many copies)
    pfam16700
    Location:559602
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
    sd00045
    Location:396429
    ANK; ANK repeat [structural motif]
  26. XM_017010079.2XP_016865568.1  synphilin-1 isoform X2

    UniProtKB/TrEMBL
    D6R9G8
  27. XM_047417929.1XP_047273885.1  synphilin-1 isoform X11

    Related
    ENSP00000378852.2, ENST00000395469.6
  28. XM_017010084.2XP_016865573.1  synphilin-1 isoform X13

  29. XM_047417926.1XP_047273882.1  synphilin-1 isoform X8

    UniProtKB/Swiss-Prot
    D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5
    UniProtKB/TrEMBL
    D6R9G8
  30. XM_047417916.1XP_047273872.1  synphilin-1 isoform X4

    UniProtKB/TrEMBL
    D6R9G8
  31. XM_047417928.1XP_047273884.1  synphilin-1 isoform X9

    UniProtKB/TrEMBL
    Q9NVG1
  32. XM_047417931.1XP_047273887.1  synphilin-1 isoform X14

    UniProtKB/TrEMBL
    B7Z995, D6RHZ0
  33. XM_047417922.1XP_047273878.1  synphilin-1 isoform X7

    UniProtKB/TrEMBL
    D6R9G8
  34. XM_047417930.1XP_047273886.1  synphilin-1 isoform X12

    UniProtKB/TrEMBL
    B7Z995, D6RHZ0
  35. XM_047417920.1XP_047273876.1  synphilin-1 isoform X5

    UniProtKB/TrEMBL
    D6R9G8
  36. XM_011543741.3XP_011542043.1  synphilin-1 isoform X1

    See identical proteins and their annotated locations for XP_011542043.1

    UniProtKB/TrEMBL
    D6R9G8
    Conserved Domains (5) summary
    cd00204
    Location:392557
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:438534
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:397452
    Ank_4; Ankyrin repeats (many copies)
    pfam16700
    Location:559602
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
    sd00045
    Location:396429
    ANK; ANK repeat [structural motif]
  37. XM_047417918.1XP_047273874.1  synphilin-1 isoform X5

    UniProtKB/TrEMBL
    D6R9G8
  38. XM_047417913.1XP_047273869.1  synphilin-1 isoform X4

    UniProtKB/TrEMBL
    D6R9G8
  39. XM_047417924.1XP_047273880.1  synphilin-1 isoform X8

    UniProtKB/Swiss-Prot
    D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5
    UniProtKB/TrEMBL
    D6R9G8
  40. XM_047417921.1XP_047273877.1  synphilin-1 isoform X6

    UniProtKB/TrEMBL
    D6R9G8
  41. XM_011543750.2XP_011542052.1  synphilin-1 isoform X10

    UniProtKB/TrEMBL
    Q9NVG1
    Conserved Domains (4) summary
    cd00204
    Location:26142
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:26119
    Ank_2; Ankyrin repeats (3 copies)
    pfam16700
    Location:144187
    SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
    sd00045
    Location:5486
    ANK; ANK repeat [structural motif]

RNA

  1. XR_001742366.2 RNA Sequence

  2. XR_001742364.2 RNA Sequence

  3. XR_001742365.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    122828188..122981079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353866.1XP_054209841.1  synphilin-1 isoform X4

    UniProtKB/TrEMBL
    D6R9G8
  2. XM_054353881.1XP_054209856.1  synphilin-1 isoform X8

    UniProtKB/Swiss-Prot
    D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5
    UniProtKB/TrEMBL
    D6R9G8
  3. XM_054353894.1XP_054209869.1  synphilin-1 isoform X14

    UniProtKB/TrEMBL
    B7Z995, D6RHZ0
  4. XM_054353882.1XP_054209857.1  synphilin-1 isoform X8

    UniProtKB/Swiss-Prot
    D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5
    UniProtKB/TrEMBL
    D6R9G8
  5. XM_054353869.1XP_054209844.1  synphilin-1 isoform X4

    UniProtKB/TrEMBL
    D6R9G8
  6. XM_054353884.1XP_054209859.1  synphilin-1 isoform X8

    UniProtKB/Swiss-Prot
    D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5
    UniProtKB/TrEMBL
    D6R9G8
  7. XM_054353858.1XP_054209833.1  synphilin-1 isoform X1

    UniProtKB/TrEMBL
    D6R9G8
  8. XM_054353856.1XP_054209831.1  synphilin-1 isoform X1

    UniProtKB/TrEMBL
    D6R9G8
  9. XM_054353868.1XP_054209843.1  synphilin-1 isoform X4

    UniProtKB/TrEMBL
    D6R9G8
  10. XM_054353865.1XP_054209840.1  synphilin-1 isoform X4

    UniProtKB/TrEMBL
    D6R9G8
  11. XM_054353879.1XP_054209854.1  synphilin-1 isoform X8

    UniProtKB/Swiss-Prot
    D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5
    UniProtKB/TrEMBL
    D6R9G8
  12. XM_054353887.1XP_054209862.1  synphilin-1 isoform X9

    UniProtKB/TrEMBL
    Q9NVG1
  13. XM_054353892.1XP_054209867.1  synphilin-1 isoform X14

    UniProtKB/TrEMBL
    B7Z995, D6RHZ0
  14. XM_054353872.1XP_054209847.1  synphilin-1 isoform X5

    UniProtKB/TrEMBL
    D6R9G8
  15. XM_054353863.1XP_054209838.1  synphilin-1 isoform X4

    UniProtKB/TrEMBL
    D6R9G8
  16. XM_054353877.1XP_054209852.1  synphilin-1 isoform X8

    UniProtKB/Swiss-Prot
    D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5
    UniProtKB/TrEMBL
    D6R9G8
  17. XM_054353855.1XP_054209830.1  synphilin-1 isoform X1

    UniProtKB/TrEMBL
    D6R9G8
  18. XM_054353871.1XP_054209846.1  synphilin-1 isoform X5

    UniProtKB/TrEMBL
    D6R9G8
  19. XM_054353862.1XP_054209837.1  synphilin-1 isoform X4

    UniProtKB/TrEMBL
    D6R9G8
  20. XM_054353861.1XP_054209836.1  synphilin-1 isoform X3

    UniProtKB/TrEMBL
    D6R9G8
  21. XM_054353860.1XP_054209835.1  synphilin-1 isoform X2

    UniProtKB/TrEMBL
    D6R9G8
  22. XM_054353889.1XP_054209864.1  synphilin-1 isoform X11

  23. XM_054353891.1XP_054209866.1  synphilin-1 isoform X13

  24. XM_054353859.1XP_054209834.1  synphilin-1 isoform X1

    UniProtKB/TrEMBL
    D6R9G8
  25. XM_054353885.1XP_054209860.1  synphilin-1 isoform X9

    UniProtKB/TrEMBL
    Q9NVG1
  26. XM_054353867.1XP_054209842.1  synphilin-1 isoform X4

    UniProtKB/TrEMBL
    D6R9G8
  27. XM_054353880.1XP_054209855.1  synphilin-1 isoform X8

    UniProtKB/Swiss-Prot
    D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5
    UniProtKB/TrEMBL
    D6R9G8
  28. XM_054353883.1XP_054209858.1  synphilin-1 isoform X8

    UniProtKB/Swiss-Prot
    D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5
    UniProtKB/TrEMBL
    D6R9G8
  29. XM_054353870.1XP_054209845.1  synphilin-1 isoform X4

    UniProtKB/TrEMBL
    D6R9G8
  30. XM_054353886.1XP_054209861.1  synphilin-1 isoform X9

    UniProtKB/TrEMBL
    Q9NVG1
  31. XM_054353893.1XP_054209868.1  synphilin-1 isoform X14

    UniProtKB/TrEMBL
    B7Z995, D6RHZ0
  32. XM_054353876.1XP_054209851.1  synphilin-1 isoform X7

    UniProtKB/TrEMBL
    D6R9G8
  33. XM_054353890.1XP_054209865.1  synphilin-1 isoform X12

    UniProtKB/TrEMBL
    B7Z995, D6RHZ0
  34. XM_054353874.1XP_054209849.1  synphilin-1 isoform X5

    UniProtKB/TrEMBL
    D6R9G8
  35. XM_054353857.1XP_054209832.1  synphilin-1 isoform X1

    UniProtKB/TrEMBL
    D6R9G8
  36. XM_054353873.1XP_054209848.1  synphilin-1 isoform X5

    UniProtKB/TrEMBL
    D6R9G8
  37. XM_054353864.1XP_054209839.1  synphilin-1 isoform X4

    UniProtKB/TrEMBL
    D6R9G8
  38. XM_054353878.1XP_054209853.1  synphilin-1 isoform X8

    UniProtKB/Swiss-Prot
    D3DSZ1, Q05BS1, Q1PSC2, Q49AC6, Q504U9, Q6L984, Q6L985, Q6L986, Q9HC59, Q9Y6H5
    UniProtKB/TrEMBL
    D6R9G8
  39. XM_054353875.1XP_054209850.1  synphilin-1 isoform X6

    UniProtKB/TrEMBL
    D6R9G8
  40. XM_054353888.1XP_054209863.1  synphilin-1 isoform X10

    UniProtKB/TrEMBL
    Q9NVG1

RNA

  1. XR_008487201.1 RNA Sequence

  2. XR_008487199.1 RNA Sequence

  3. XR_008487200.1 RNA Sequence