U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CIRSR corepressor of RBPJ and splicing regulator [ Homo sapiens (human) ]

Gene ID: 9541, updated on 3-May-2025
Official Symbol
CIRSRprovided by HGNC
Official Full Name
corepressor of RBPJ and splicing regulatorprovided by HGNC
Primary source
HGNC:HGNC:24217
See related
Ensembl:ENSG00000138433 MIM:605228; AllianceGenome:HGNC:24217
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CIR; CIR1; THE1B/CIR1
Summary
Enables histone deacetylase binding activity; protein kinase binding activity; and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in centrosome and nuclear speck. Part of protein-containing complex. [provided by Alliance of Genome Resources, May 2025]
Expression
Ubiquitous expression in bone marrow (RPKM 20.7), testis (RPKM 18.7) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table
See CIRSR in Genome Data Viewer
Location:
2q31.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (174348022..174395712, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (174836713..174884400, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (175212750..175260440, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:175190859-175191676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:175193313-175194128 Neighboring gene VISTA enhancer hs860 Neighboring gene long intergenic non-protein coding RNA 1305 Neighboring gene uncharacterized LOC102724194 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12125 Neighboring gene VISTA enhancer hs953 Neighboring gene Sharpr-MPRA regulatory region 8106 Neighboring gene Sp9 transcription factor Neighboring gene ReSE screen-validated silencer GRCh37_chr2:175256788-175256952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:175260886-175261386 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:175274337-175274938 Neighboring gene secernin 3 Neighboring gene G protein-coupled receptor 155 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:175351272-175351454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12126

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC. Zhang J, et al. J Virol, 2001 Mar. PMID 11222720, Free PMC Article
  2. Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus gene expression in dually infected PEL cells. Krithivas A, et al. J Virol, 2000 Oct. PMID 11000236, Free PMC Article
  3. Polymorphisms in cancer-related pathway genes and lung cancer. Lee SY, et al. Eur Respir J, 2016 Oct. PMID 27587543
  4. RYBP modulates embryonic neurogenesis involving the Notch signaling pathway in a PRC1-independent pattern. Li Q, et al. Stem Cell Reports, 2021 Dec 14. PMID 34798064, Free PMC Article
  5. Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex. Zhou S, et al. Mol Cell Biol, 2001 Sep. PMID 11509665, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone deacetylase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
corepressor interacting with RBPJ 1
Names
CBF1 (RBPJ) interacting corepressor 1
CBF1-interacting corepressor
corepressor interacting with RBPJ, 1
corepressor interacting with RBPJ, CIR1
recepin

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004882.4 → NP_004873.3  corepressor interacting with RBPJ 1

    See identical proteins and their annotated locations for NP_004873.3

    Status: VALIDATED

    Source sequence(s)
    AC018470, BC015040, BC046098, BU596189
    Consensus CDS
    CCDS2256.1
    UniProtKB/Swiss-Prot
    A6NFI6, A8K8M4, O95367, Q12804, Q4G1B9, Q6PJI4, Q86X95, Q8IWI2
    UniProtKB/TrEMBL
    A0PJI7
    Related
    ENSP00000339723.3, ENST00000342016.8
    Conserved Domains (1) summary
    pfam10197
    Location:13 → 49
    Cir_N; N-terminal domain of CBF1 interacting co-repressor CIR

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    174348022..174395712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    174836713..174884400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199075.1: Suppressed sequence

    Description
    NM_199075.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86X95.1 GenPept UniProtKB/Swiss-Prot:Q86X95

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools