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TP53I11 tumor protein p53 inducible protein 11 [ Homo sapiens (human) ]

Gene ID: 9537, updated on 7-Jun-2020

Summary

Official Symbol
TP53I11provided by HGNC
Official Full Name
tumor protein p53 inducible protein 11provided by HGNC
Primary source
HGNC:HGNC:16842
See related
Ensembl:ENSG00000175274 MIM:617867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIG11
Expression
Ubiquitous expression in lung (RPKM 12.0), fat (RPKM 11.2) and 25 other tissues See more
Orthologs

Genomic context

See TP53I11 in Genome Data Viewer
Location:
11p11.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (44932348..44951306, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (44907454..44972919, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2704 Neighboring gene Sharpr-MPRA regulatory region 3015 Neighboring gene tetraspanin 18 Neighboring gene uncharacterized LOC105376649 Neighboring gene long intergenic non-protein coding RNA 2685 Neighboring gene uncharacterized LOC105376650

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tumor protein p53-inducible protein 11
Names
p53-induced gene 11 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258320.2NP_001245249.1  tumor protein p53-inducible protein 11 isoform a

    See identical proteins and their annotated locations for NP_001245249.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 all encode the same isoform (a).
    Source sequence(s)
    AC068858, AC092733
    Consensus CDS
    CCDS7911.1
    UniProtKB/Swiss-Prot
    O14683
    Related
    ENSP00000436152.1, ENST00000533940.5
    Conserved Domains (1) summary
    pfam14936
    Location:10188
    p53-inducible11; tumor protein p53-inducible protein 11
  2. NM_001258321.1NP_001245250.1  tumor protein p53-inducible protein 11 isoform a

    See identical proteins and their annotated locations for NP_001245250.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 all encode the same isoform (a).
    Source sequence(s)
    AC092733, AK054815, DA190266, DA697978
    Consensus CDS
    CCDS7911.1
    UniProtKB/Swiss-Prot
    O14683
    Related
    ENSP00000309532.5, ENST00000308212.9
    Conserved Domains (1) summary
    pfam14936
    Location:10188
    p53-inducible11; tumor protein p53-inducible protein 11
  3. NM_001258322.1NP_001245251.1  tumor protein p53-inducible protein 11 isoform a

    See identical proteins and their annotated locations for NP_001245251.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 all encode the same isoform (a).
    Source sequence(s)
    AC092733, AK054815, DA115495, DA190266
    Consensus CDS
    CCDS7911.1
    UniProtKB/Swiss-Prot
    O14683
    Conserved Domains (1) summary
    pfam14936
    Location:10188
    p53-inducible11; tumor protein p53-inducible protein 11
  4. NM_001258323.3NP_001245252.1  tumor protein p53-inducible protein 11 isoform a

    See identical proteins and their annotated locations for NP_001245252.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 all encode the same isoform (a).
    Source sequence(s)
    AC068858, AC092733
    Consensus CDS
    CCDS7911.1
    UniProtKB/Swiss-Prot
    O14683
    Related
    ENSP00000379009.3, ENST00000395648.7
    Conserved Domains (1) summary
    pfam14936
    Location:10188
    p53-inducible11; tumor protein p53-inducible protein 11
  5. NM_001258324.1NP_001245253.1  tumor protein p53-inducible protein 11 isoform a

    See identical proteins and their annotated locations for NP_001245253.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 all encode the same isoform (a).
    Source sequence(s)
    AC092733, AK054815, AL537510, DA190266
    Consensus CDS
    CCDS7911.1
    UniProtKB/Swiss-Prot
    O14683
    Related
    ENSP00000481456.1, ENST00000616990.4
    Conserved Domains (1) summary
    pfam14936
    Location:10188
    p53-inducible11; tumor protein p53-inducible protein 11
  6. NM_001318384.2NP_001305313.1  tumor protein p53-inducible protein 11 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 all encode the same isoform (a).
    Source sequence(s)
    AC068858, AC092733
    Consensus CDS
    CCDS7911.1
    UniProtKB/Swiss-Prot
    O14683
    Conserved Domains (1) summary
    pfam14936
    Location:10188
    p53-inducible11; tumor protein p53-inducible protein 11
  7. NM_001318385.1NP_001305314.1  tumor protein p53-inducible protein 11 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 all encode the same isoform (a).
    Source sequence(s)
    AC092733, AK056379, DA190266, DA778197, HY350915
    Consensus CDS
    CCDS7911.1
    UniProtKB/Swiss-Prot
    O14683
    Conserved Domains (1) summary
    pfam14936
    Location:10188
    p53-inducible11; tumor protein p53-inducible protein 11
  8. NM_001318386.1NP_001305315.1  tumor protein p53-inducible protein 11 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 all encode the same isoform (a).
    Source sequence(s)
    AC092733, AK056379, DA190266, DA410127, HY350915
    Consensus CDS
    CCDS7911.1
    UniProtKB/Swiss-Prot
    O14683
    Conserved Domains (1) summary
    pfam14936
    Location:10188
    p53-inducible11; tumor protein p53-inducible protein 11
  9. NM_001318387.2NP_001305316.1  tumor protein p53-inducible protein 11 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and lacks two alternate coding exons compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter and has a different internal segment compared to isoform a.
    Source sequence(s)
    AC068858, AC092733
    Conserved Domains (1) summary
    pfam14936
    Location:10136
    p53-inducible11; Tumour protein p53-inducible protein 11
  10. NM_001318388.2NP_001305317.1  tumor protein p53-inducible protein 11 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC068858, AC092733
    UniProtKB/TrEMBL
    Q8N8U5
    Conserved Domains (1) summary
    pfam14936
    Location:10135
    p53-inducible11; Tumour protein p53-inducible protein 11
  11. NM_001318389.2NP_001305318.1  tumor protein p53-inducible protein 11 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (d) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC068858, AC092733
    Conserved Domains (1) summary
    pfam14936
    Location:34113
    p53-inducible11; tumor protein p53-inducible protein 11
  12. NM_001318390.2NP_001305319.1  tumor protein p53-inducible protein 11 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR and uses an alternate splice junction in the coding region compared to variant 1, that causes a frameshift. The resulting isoform (e) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC068858, AC092733
    Conserved Domains (1) summary
    pfam14936
    Location:1110
    p53-inducible11; Tumour protein p53-inducible protein 11
  13. NM_006034.5NP_006025.2  tumor protein p53-inducible protein 11 isoform a

    See identical proteins and their annotated locations for NP_006025.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6, 7, 8, and 9 all encode the same isoform (a).
    Source sequence(s)
    AC068858, AC092733
    Consensus CDS
    CCDS7911.1
    UniProtKB/Swiss-Prot
    O14683
    Related
    ENSP00000433474.1, ENST00000525680.5
    Conserved Domains (1) summary
    pfam14936
    Location:10188
    p53-inducible11; tumor protein p53-inducible protein 11

RNA

  1. NR_134612.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR and contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC068858, AC092733

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    44932348..44951306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520478.2XP_011518780.1  tumor protein p53-inducible protein 11 isoform X1

    See identical proteins and their annotated locations for XP_011518780.1

    UniProtKB/Swiss-Prot
    O14683
    Related
    ENSP00000433454.1, ENST00000528473.5
    Conserved Domains (1) summary
    pfam14936
    Location:10188
    p53-inducible11; tumor protein p53-inducible protein 11
  2. XM_005253227.4XP_005253284.1  tumor protein p53-inducible protein 11 isoform X1

    See identical proteins and their annotated locations for XP_005253284.1

    UniProtKB/Swiss-Prot
    O14683
    Conserved Domains (1) summary
    pfam14936
    Location:10188
    p53-inducible11; tumor protein p53-inducible protein 11
  3. XM_011520477.2XP_011518779.1  tumor protein p53-inducible protein 11 isoform X1

    See identical proteins and their annotated locations for XP_011518779.1

    UniProtKB/Swiss-Prot
    O14683
    Conserved Domains (1) summary
    pfam14936
    Location:10188
    p53-inducible11; tumor protein p53-inducible protein 11
  4. XM_011520476.2XP_011518778.1  tumor protein p53-inducible protein 11 isoform X1

    See identical proteins and their annotated locations for XP_011518778.1

    UniProtKB/Swiss-Prot
    O14683
    Conserved Domains (1) summary
    pfam14936
    Location:10188
    p53-inducible11; tumor protein p53-inducible protein 11
  5. XM_017018581.1XP_016874070.1  tumor protein p53-inducible protein 11 isoform X1

    UniProtKB/Swiss-Prot
    O14683
    Conserved Domains (1) summary
    pfam14936
    Location:10188
    p53-inducible11; tumor protein p53-inducible protein 11
  6. XM_011520475.2XP_011518777.1  tumor protein p53-inducible protein 11 isoform X1

    See identical proteins and their annotated locations for XP_011518777.1

    UniProtKB/Swiss-Prot
    O14683
    Conserved Domains (1) summary
    pfam14936
    Location:10188
    p53-inducible11; tumor protein p53-inducible protein 11
  7. XM_017018580.2XP_016874069.1  tumor protein p53-inducible protein 11 isoform X1

    UniProtKB/Swiss-Prot
    O14683
    Conserved Domains (1) summary
    pfam14936
    Location:10188
    p53-inducible11; tumor protein p53-inducible protein 11
  8. XM_024448777.1XP_024304545.1  tumor protein p53-inducible protein 11 isoform X1

    Conserved Domains (1) summary
    pfam14936
    Location:10188
    p53-inducible11; tumor protein p53-inducible protein 11
  9. XM_005253229.2XP_005253286.1  tumor protein p53-inducible protein 11 isoform X2

    See identical proteins and their annotated locations for XP_005253286.1

    UniProtKB/TrEMBL
    U3KQ32
    Related
    ENSP00000475501.1, ENST00000531928.6
    Conserved Domains (1) summary
    pfam14936
    Location:10114
    p53-inducible11; Tumour protein p53-inducible protein 11

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001076787.1: Suppressed sequence

    Description
    NM_001076787.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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