cirA [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: cirA
Primary source: ASAP:ABE-0007126
Locus tag: b2155
See related: ECOCYC:EG10155
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: cir; ECK2148; feuA
Summary: Cir is a member of the Outer Membrane Receptor (OMR) family of porins. [More information is available at EcoCyc: EG10155].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Hfq acts as the repressor of cirA mRNA translation in the absence of sRNA.
Title: Antagonistic functions between the RNA chaperone Hfq and an sRNA regulate sensitivity to the antibiotic colicin.
N-terminus verified by Edman degradation on mature peptide
Title: Cloning and promoter identification of the iron-regulated cir gene of Escherichia coli.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables colicin transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables siderophore uptake transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables siderophore-iron transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in bacteriocin transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular iron ion homeostasis	NAS Non-traceable Author Statement more info	PubMed
involved_in iron ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in siderophore transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within siderophore transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in siderophore-dependent iron import into cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cell outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cell outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell outer membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
part_of transmembrane transporter complex	NAS Non-traceable Author Statement more info	PubMed

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