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fimB Type 1 fimbriae regulatory protein FimB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948832, updated on 19-Sep-2024

Summary

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Official Symbol
fimB
Official Full Name
Type 1 fimbriae regulatory protein FimB
Primary source
ECOCYC:EG10309
Locus tag
b4312
See related
ASAP:ABE-0014141
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4303; pil
Summary
FimB, along with FimE, is a recombinase in Escherichia coli which catalyzes the site-specific recombination required for inversion of a 314-bp invertible DNA element, the fim switch (fimS), to control transcription of the type I fimbrial structural genes--a process known as phase-variation switching. fimS contains the promoter for expression of the fimbrial structural genes. [More information is available at EcoCyc: EG10309].
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Genomic context

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Sequence:
NC_000913.3 (4540957..4541559)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene N-acetylneuraminate mutarotase Neighboring gene N-acetylneuraminate outer membrane channel Neighboring gene regulator for fimA Neighboring gene type 1 fimbriae major subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interaction of the FimB integrase with the fimS invertible DNA element in Escherichia coli in vivo and in vitro. Burns LS, et al. J Bacteriol, 2000 May. PMID 10781567, Free PMC Article
  2. Multicopy fimB gene expression in Escherichia coli: binding to inverted repeats in vivo, effect on fimA gene transcription and DNA inversion. Dove SL, et al. Mol Microbiol, 1996 Sep. PMID 8898385
  3. OmpR regulation of the uropathogenic Escherichia coli fimB gene in an acidic/high osmolality environment. Rentschler AE, et al. Microbiology (Reading), 2013 Feb. PMID 23175504, Free PMC Article
  4. SlyA protein activates fimB gene expression and type 1 fimbriation in Escherichia coli K-12. McVicker G, et al. J Biol Chem, 2011 Sep 16. PMID 21768111, Free PMC Article
  5. Comparative analysis of FimB and FimE recombinase activity. Holden N, et al. Microbiology (Reading), 2007 Dec. PMID 18048927

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results demonstrate a complex role for RfaH as a regulator of fimB expression via the suppression micA non-coding RNA.
    Title: RfaH suppresses small RNA MicA inhibition of fimB expression in Escherichia coli K-12.
  2. Together these results suggest that OmpR regulates fimB in uropathogenic Escherichia coli and may be post-transcriptionally regulated in a low pH/high osmolality environment.
    Title: OmpR regulation of the uropathogenic Escherichia coli fimB gene in an acidic/high osmolality environment.
  3. the rarely used UUG initiation codon limits slyA expression and that low SlyA levels limit fimB expression.
    Title: SlyA protein activates fimB gene expression and type 1 fimbriation in Escherichia coli K-12.
  4. In vitro transcription studies demonstrate that ppGpp and DksA can stimulate transcription from the fimB P2 promoter both independently and codependently.
    Title: Regulation of the fimB promoter: a case of differential regulation by ppGpp and DksA in vivo.
  5. FimB inverts the switch in the ON-to-OFF and OFF-to-ON directions with similar efficiencies, whereas FimE inverts it predominantly in the ON-to-OFF direction.
    Title: DNA sequence heterogeneity in Fim tyrosine-integrase recombinase-binding elements and functional motif asymmetries determine the directionality of the fim genetic switch in Escherichia coli K-12.
  6. By controlling transcription and ratio of fimB and fimE, RcsB regulates type 1 piliation.
    Title: The two-component response regulator RcsB regulates type 1 piliation in Escherichia coli.
  7. The data support a model in which the FimB and FimE recombinases differ in loading order and co-operative interactions. PapB exploits this difference and FimE becomes susceptible when its normal loading is restricted or changed.
    Title: Comparative analysis of FimB and FimE recombinase activity.
  8. IHF is necessary for the control of fimB expression in response to sialic acid and N-acetylglucosamine
    Title: Multiple co-regulatory elements and IHF are necessary for the control of fimB expression in response to sialic acid and N-acetylglucosamine in Escherichia coli K-12.
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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in DNA integration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA integration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Type 1 fimbriae regulatory protein FimB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4540957..4541559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418732.1 Type 1 fimbriae regulatory protein FimB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418732.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A4Y6GMQ3, A0A4Y6GMV7, A0A5B9AMW1
    Conserved Domains (1) summary
    PRK09870
    Location:1 → 200
    PRK09870; tyrosine recombinase; Provisional
Nucleotide Protein
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Other Literature Sources
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Research Materials