U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

pepA aminopeptidase A/I [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948791, updated on 25-Jun-2025
Official Symbol
pepA
Official Full Name
aminopeptidase A/I
Primary source
ECOCYC:EG10694
Locus tag
b4260
See related
ASAP:ABE-0013953
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
carP; ECK4253; xerB
Summary
PepA has a broad specificity for successive removal of many N-terminal amino acids, although leucine is preferred as the residue N-terminal to the cleavage site. [More information is available at EcoGene: EG10694]. Aminopeptidase A/I is a peptidase that binds DNA and is required for maintenance of plasmid monomers, which is critical for proper plasmid segregation . [More information is available at EcoCyc: EG10694].
NEW
Try the new Gene table
Try the new Transcript table
Sequence:
NC_000913.3 (4484440..4485951, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene valine--tRNA ligase Neighboring gene DNA polymerase III subunit chi Neighboring gene protein YtgB Neighboring gene protein YtgA

Genomic Sequence:
NC_000913.3

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables aminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables aminopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription antitermination factor activity, DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
aminopeptidase A/I
NP_418681.1

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4484440..4485951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418681.1 aminopeptidase A/I [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418681.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9ALR5, A0A6C9QGK6, Q7X4V5
    Conserved Domains (1) summary
    PRK00913
    Location:1495
    PRK00913; multifunctional aminopeptidase A; Provisional