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pepA aminopeptidase A/I [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948791, updated on 6-May-2021

Summary

Gene symbol
pepA
Gene description
aminopeptidase A/I
Primary source
ASAP:ABE-0013953
Locus tag
b4260
See related
ECOCYC:EG10694
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
carP; ECK4253; xerB
Summary
PepA has a broad specificity for successive removal of many N-terminal amino acids, although leucine is preferred as the residue N-terminal to the cleavage site. [More information is available at EcoGene: EG10694]. Aminopeptidase A/I is a peptidase that binds DNA and is required for maintenance of plasmid monomers, which is critical for proper plasmid segregation . [More information is available at EcoCyc: EG10694].
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Genomic context

Sequence:
NC_000913.3 (4484440..4485951, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene valine--tRNA ligase Neighboring gene DNA polymerase III subunit chi Neighboring gene protein YtgA Neighboring gene lipopolysaccharide transport system protein LptF Neighboring gene lipopolysaccharide transport system protein LptG

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables aminopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloexopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription antitermination factor activity, DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
aminopeptidase A/I
NP_418681.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4484440..4485951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418681.1 aminopeptidase A/I [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418681.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P68767
    Conserved Domains (1) summary
    PRK00913
    Location:1495
    PRK00913; multifunctional aminopeptidase A; Provisional
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