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nrdG anaerobic ribonucleoside-triphosphate reductase activating protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948757, updated on 10-Feb-2026
Official Symbol
nrdG
Official Full Name
anaerobic ribonucleoside-triphosphate reductase activating protein
Primary source
ECOCYC:G812
Locus tag
b4237
See related
ASAP:ABE-0013860
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4232; yjgE
Summary
FNR regulon. [More information is available at EcoGene: EG12523]. An nrdG null mutant does not grow under entirely anaerobic conditions, but grows under aerobic or microaerophilic conditions due to the activity of NrdA and/or NrdB . [More information is available at EcoCyc: G812].
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Sequence:
NC_000913.3 (4459900..4460364, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene metalloprotease subunit TldE Neighboring gene pseudo Neighboring gene anaerobic ribonucleoside-triphosphate reductase Neighboring gene trehalose-6-phosphate hydrolase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Molecular properties of pyruvate formate-lyase activating enzyme. Wong KK, et al. Biochemistry, 1993 Dec 28. PMID 8260492
  2. An iron-sulfur center and a free radical in the active anaerobic ribonucleotide reductase of Escherichia coli. Mulliez E, et al. J Biol Chem, 1993 Feb 5. PMID 8381402
  3. The activating component of the anaerobic ribonucleotide reductase from Escherichia coli. An iron-sulfur center with only three cysteines. Tamarit J, et al. J Biol Chem, 2000 May 26. PMID 10821845
  4. Deoxyribonucleotide synthesis in anaerobic microorganisms: the class III ribonucleotide reductase. Fontecave M, et al. Prog Nucleic Acid Res Mol Biol, 2002. PMID 12206460
  5. Fumarate and nitrate reduction (FNR) dependent activation of the Escherichia coli anaerobic ribonucleotide reductase nrdDG promoter. Roca I, et al. Int Microbiol, 2008 Mar. PMID 18683632

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables [formate-C-acetyltransferase]-activating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables glycyl-radical enzyme activating activity IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in 2'-deoxyribonucleotide biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within nucleobase-containing small molecule interconversion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleobase-containing small molecule interconversion NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of anaerobic ribonucleoside-triphosphate reductase complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
anaerobic ribonucleoside-triphosphate reductase activating protein

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4459900..4460364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418658.1 anaerobic ribonucleoside-triphosphate reductase activating protein

    See identical proteins and their annotated locations for NP_418658.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5N8HH25
    Conserved Domains (1) summary
    PRK11121
    Location:1 → 154
    nrdG; anaerobic ribonucleoside-triphosphate reductase-activating protein
Nucleotide Protein
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