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nrdD anaerobic ribonucleoside-triphosphate reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948755, updated on 19-Sep-2024

Summary

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Official Symbol
nrdD
Official Full Name
anaerobic ribonucleoside-triphosphate reductase
Primary source
ECOCYC:EG11417
Locus tag
b4238
See related
ASAP:ABE-0013865
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4233
Summary
Activated NrdD is predicted to be cleaved by oxygen at the Gly681 radical, dropping the last 31 aa. [More information is available at EcoGene: EG11417]. The NrdD reductase is activated by the NrdG activase under anaerobic conditions and is inactivated by oxygen. [More information is available at EcoCyc: EG11417].
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Genomic context

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Sequence:
NC_000913.3 (4460522..4462660, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene anaerobic ribonucleoside-triphosphate reductase activating protein Neighboring gene trehalose-6-phosphate hydrolase Neighboring gene trehalose-specific PTS enzyme IIBC component

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Zn center of the anaerobic ribonucleotide reductase from E. coli. Luttringer F, et al. J Biol Inorg Chem, 2009 Aug. PMID 19381696
  2. Interactions of 2'-modified azido- and haloanalogs of deoxycytidine 5'-triphosphate with the anaerobic ribonucleotide reductase of Escherichia coli. Eliasson R, et al. J Biol Chem, 1994 Oct 21. PMID 7929323
  3. Allosteric control of the substrate specificity of the anaerobic ribonucleotide reductase from Escherichia coli. Eliasson R, et al. J Biol Chem, 1994 Oct 21. PMID 7929317
  4. Oxygen-sensitive ribonucleoside triphosphate reductase is present in anaerobic Escherichia coli. Fontecave M, et al. Proc Natl Acad Sci U S A, 1989 Apr. PMID 2648390, Free PMC Article
  5. Activation of the anaerobic ribonucleotide reductase from Escherichia coli by S-adenosylmethionine. Harder J, et al. J Biol Chem, 1992 Dec 15. PMID 1460050

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: A possible glycine radical in anaerobic ribonucleotide reductase from Escherichia coli: nucleotide sequence of the cloned nrdD gene.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables dATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables dGTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables pyrimidine deoxyribonucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ribonucleoside-triphosphate reductase (thioredoxin) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonucleoside-triphosphate reductase (thioredoxin) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribonucleoside-triphosphate reductase (thioredoxin) activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within 2'-deoxyribonucleotide biosynthetic process EXP
Inferred from Experiment
more info
 PubMed 
involved_in 2'-deoxyribonucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within 2'-deoxyribonucleotide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 2'-deoxyribonucleotide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 2'-deoxyribonucleotide biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleobase-containing small molecule interconversion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleobase-containing small molecule interconversion NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of anaerobic ribonucleoside-triphosphate reductase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaerobic ribonucleoside-triphosphate reductase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of anaerobic ribonucleoside-triphosphate reductase complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
anaerobic ribonucleoside-triphosphate reductase
NP_418659.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4460522..4462660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418659.1 anaerobic ribonucleoside-triphosphate reductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418659.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3R0NDP9, A0A5B9AQK8
    Conserved Domains (1) summary
    PRK09263
    Location:1 → 711
    PRK09263; anaerobic ribonucleoside triphosphate reductase; Provisional
Nucleotide Protein
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