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dcuA C4-dicarboxylate transporter DcuA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948659, updated on 30-Jul-2025
Official Symbol
dcuA
Official Full Name
C4-dicarboxylate transporter DcuA
Primary source
ECOCYC:EG11225
Locus tag
b4138
See related
ASAP:ABE-0013546
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4132; genA
Summary
IT (Ion Transporter) superfamily (Prakash, 2003). [More information is available at EcoGene: EG11225]. The DcuA transporter is one of three transporters known to be responsible for the uptake of C4-dicarboxylates such as fumarate under anaerobic conditions. [More information is available at EcoCyc: EG11225].
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Sequence:
NC_000913.3 (4365472..4366773, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional regulator DicD Neighboring gene thiol-disulfide exchange protein DsbD Neighboring gene copper binding protein CutA Neighboring gene ncRNA Neighboring gene aspartate ammonia-lyase Neighboring gene protein FxsA

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Cloning and nucleotide sequence of the aspartase gene of Escherichia coli W. Takagi JS, et al. Nucleic Acids Res, 1985 Mar 25. PMID 2987841, Free PMC Article
  2. Influence of C(4) -Dcu transporters on hydrogenase and formate dehydrogenase activities in stationary phase-grown fermenting Escherichia coli. Karapetyan L, et al. IUBMB Life, 2020 Aug. PMID 32277802
  3. Anaerobic fumarate transport in Escherichia coli by an fnr-dependent dicarboxylate uptake system which is different from the aerobic dicarboxylate uptake system. Engel P, et al. J Bacteriol, 1992 Sep. PMID 1512189, Free PMC Article
  4. Transport of C4-dicarboxylates by anaerobically grown Escherichia coli. Energetics and mechanism of exchange, uptake and efflux. Engel P, et al. Eur J Biochem, 1994 Jun 1. PMID 8020497
  5. C4-dicarboxylate metabolons: interaction of C4-dicarboxylate transporters of Escherichia coli with cytosolic enzymes. Schubert C, et al. FEMS Microbiol Lett, 2022 Sep 22. PMID 36044995

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Influence of C4 -Dcu transporters on hydrogenase and formate dehydrogenase activities in stationary phase-grown fermenting Escherichia coli.
    Title: Influence of C(4) -Dcu transporters on hydrogenase and formate dehydrogenase activities in stationary phase-grown fermenting Escherichia coli.
  2. In this work, it is shown that DcuA is required for aerobic growth with L-aspartate as a nitrogen source.
    Title: DcuA of aerobically grown Escherichia coli serves as a nitrogen shuttle (L-aspartate/fumarate) for nitrogen uptake.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables C4-dicarboxylate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables C4-dicarboxylate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables succinate:fumarate antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate:fumarate antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in C4-dicarboxylate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within C4-dicarboxylate transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in C4-dicarboxylate transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within L-aspartate import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within anaerobic respiration EXP
Inferred from Experiment
more info
 PubMed 
involved_in anaerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fumarate transport IEA
Inferred from Electronic Annotation
more info
  
involved_in succinate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 
Preferred Names
C4-dicarboxylate transporter DcuA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4365472..4366773 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418561.1 C4-dicarboxylate transporter DcuA

    See identical proteins and their annotated locations for NP_418561.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A765T1T9
    Conserved Domains (1) summary
    PRK09412
    Location:1 → 433
    PRK09412; anaerobic C4-dicarboxylate transporter; Reviewed
Nucleotide Protein
Heading Accession and Version

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