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btuB cobalamin outer membrane transporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948468, updated on 3-Dec-2024

Summary

Official Symbol
btuB
Official Full Name
cobalamin outer membrane transporter
Primary source
ECOCYC:EG10126
Locus tag
b3966
See related
ASAP:ABE-0012987
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
bfe; cer; ECK3958
Summary
BtuB translation is regulated by adenosylcobalamin binding directly to btuB mRNA, a B12-responsive riboswitch. [More information is available at EcoGene: EG10126]. BtuB is an outer membrane porin that mediates high affinity binding and TonB- dependent active transport of vitamin B12 (cyanocobalamin) across the outer membrane. [More information is available at EcoCyc: EG10126].
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Genomic context

Sequence:
NC_000913.3 (4163639..4165483)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor FabR Neighboring gene DUF1422 domain-containing inner membrane protein YijD Neighboring gene tRNA m(5)U54 methyltransferase Neighboring gene glutamate racemase Neighboring gene 16S ribosomal RNA Neighboring gene tRNA-Glu

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ABC-type vitamin B12 transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables porin activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables vitamin transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cobalamin transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cobalamin transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cobalamin transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cobalamin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cobalamin transport NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of monoatomic ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in vitamin transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cell outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cell outer membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of pore complex IEA
Inferred from Electronic Annotation
more info
 
part_of transmembrane transporter complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
cobalamin outer membrane transporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4163639..4165483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418401.1 cobalamin outer membrane transporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418401.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2H4TS82
    Conserved Domains (1) summary
    PRK10641
    Location:1614
    btuB; TonB-dependent vitamin B12 receptor BtuB