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metF 5,10-methylenetetrahydrofolate reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948432, updated on 6-Jun-2024

Summary

Gene symbol
metF
Gene description
5,10-methylenetetrahydrofolate reductase
Primary source
ASAP:ABE-0012897
Locus tag
b3941
See related
ECOCYC:EG10585
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3933
Summary
Upregulated by GSNO in defined medium. [More information is available at EcoGene: EG10585].
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Genomic context

Sequence:
NC_000913.3 (4132616..4133506)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene O-succinylhomoserine(thiol)-lyase/O-succinylhomoserine lyase Neighboring gene fused aspartate kinase/homoserine dehydrogenase 2 Neighboring gene catalase/hydroperoxidase HPI Neighboring gene cystine exporter

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables FAD binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables FAD binding IDA
Inferred from Direct Assay
more info
PubMed 
enables methylenetetrahydrofolate reductase (NAD(P)H) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables methylenetetrahydrofolate reductase (NAD(P)H) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables methylenetetrahydrofolate reductase (NAD(P)H) activity IEA
Inferred from Electronic Annotation
more info
 
enables methylenetetrahydrofolate reductase (NADH) activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in methionine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in tetrahydrofolate interconversion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
5,10-methylenetetrahydrofolate reductase
NP_418376.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4132616..4133506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418376.1 5,10-methylenetetrahydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418376.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A444REP9
    Conserved Domains (1) summary
    PRK09432
    Location:1296
    metF; methylenetetrahydrofolate reductase