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waaZ lipopolysaccharide core biosynthesis protein WaaZ [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948146, updated on 19-Nov-2025
Official Symbol
waaZ
Official Full Name
lipopolysaccharide core biosynthesis protein WaaZ
Primary source
ECOCYC:EG11426
Locus tag
b3624
See related
ASAP:ABE-0011854
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3614; rfaZ
Summary
The lipopolysaccharide of Escherichia coli K-12 consists of two major components: the hydrophobic lipid A moiety inserted into the outer membrane and the phosphorylated core oligosaccharide . [More information is available at EcoCyc: EG11426].
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Sequence:
NC_000913.3 (3799345..3800196, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene O-antigen ligase Neighboring gene protein YibY Neighboring gene putative ADP-heptose:LPS heptosyltransferase 4 Neighboring gene lipopolysaccharide core heptose (II) kinase Neighboring gene UDP-glucose:(glucosyl)LPS alpha-1,2-glucosyltransferase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Overexpression of the waaZ gene leads to modification of the structure of the inner core region of Escherichia coli lipopolysaccharide, truncation of the outer core, and reduction of the amount of O polysaccharide on the cell surface. Frirdich E, et al. J Bacteriol, 2003 Mar. PMID 12591884, Free PMC Article
  2. SoxRS-mediated lipopolysaccharide modification enhances resistance against multiple drugs in Escherichia coli. Lee JH, et al. J Bacteriol, 2009 Jul. PMID 19376854, Free PMC Article
  3. Role of the rfaG and rfaP genes in determining the lipopolysaccharide core structure and cell surface properties of Escherichia coli K-12. Parker CT, et al. J Bacteriol, 1992 Apr. PMID 1348243, Free PMC Article
  4. Role of Escherichia coli K-12 rfa genes and the rfp gene of Shigella dysenteriae 1 in generation of lipopolysaccharide core heterogeneity and attachment of O antigen. Klena JD, et al. J Bacteriol, 1992 Nov. PMID 1385388, Free PMC Article
  5. Physical maps of the rfa loci of Escherichia coli K-12 and Salmonella typhimurium. Schnaitman CA, et al. J Bacteriol, 1991 Dec. PMID 1938935, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Synthesis of different glycoforms is regulated by differential expression of WaaZ (KdoIII transferase) and WaaR (glycosyltransferase).
    Title: Molecular basis of lipopolysaccharide heterogeneity in Escherichia coli: envelope stress-responsive regulators control the incorporation of glycoforms with a third 3-deoxy-α-D-manno-oct-2-ulosonic acid and rhamnose.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables Kdo transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipopolysaccharide core region biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipopolysaccharide core region biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 
Preferred Names
lipopolysaccharide core biosynthesis protein WaaZ
NP_418081.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3799345..3800196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418081.1 lipopolysaccharide core biosynthesis protein WaaZ

    See identical proteins and their annotated locations for NP_418081.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7A6N4W4
    Conserved Domains (1) summary
    PRK09822
    Location:1 → 269
    PRK09822; lipopolysaccharide core biosynthesis protein; Provisional
Nucleotide Protein
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