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waaZ lipopolysaccharide core biosynthesis protein WaaZ [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948146, updated on 25-Jan-2024

Summary

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Gene symbol
waaZ
Gene description
lipopolysaccharide core biosynthesis protein WaaZ
Primary source
ASAP:ABE-0011854
Locus tag
b3624
See related
ECOCYC:EG11426
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3614; rfaZ
Summary
The lipopolysaccharide of Escherichia coli K-12 consists of two major components: the hydrophobic lipid A moiety inserted into the outer membrane and the phosphorylated core oligosaccharide . [More information is available at EcoCyc: EG11426].
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Genomic context

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Sequence:
NC_000913.3 (3799345..3800196, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene O-antigen ligase Neighboring gene protein YibY Neighboring gene putative ADP-heptose:LPS heptosyltransferase 4 Neighboring gene lipopolysaccharide core heptose (II) kinase Neighboring gene UDP-glucose:(glucosyl)LPS alpha-1,2-glucosyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of the waaZ gene leads to modification of the structure of the inner core region of Escherichia coli lipopolysaccharide, truncation of the outer core, and reduction of the amount of O polysaccharide on the cell surface. Frirdich E, et al. J Bacteriol, 2003 Mar. PMID 12591884, Free PMC Article
  2. SoxRS-mediated lipopolysaccharide modification enhances resistance against multiple drugs in Escherichia coli. Lee JH, et al. J Bacteriol, 2009 Jul. PMID 19376854, Free PMC Article
  3. Molecular basis of lipopolysaccharide heterogeneity in Escherichia coli: envelope stress-responsive regulators control the incorporation of glycoforms with a third 3-deoxy-α-D-manno-oct-2-ulosonic acid and rhamnose. Klein G, et al. J Biol Chem, 2011 Dec 16. PMID 22021036, Free PMC Article
  4. Molecular basis for structural diversity in the core regions of the lipopolysaccharides of Escherichia coli and Salmonella enterica. Heinrichs DE, et al. Mol Microbiol, 1998 Oct. PMID 9791168
  5. Physical maps of the rfa loci of Escherichia coli K-12 and Salmonella typhimurium. Schnaitman CA, et al. J Bacteriol, 1991 Dec. PMID 1938935, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Synthesis of different glycoforms is regulated by differential expression of WaaZ (KdoIII transferase) and WaaR (glycosyltransferase).
    Title: Molecular basis of lipopolysaccharide heterogeneity in Escherichia coli: envelope stress-responsive regulators control the incorporation of glycoforms with a third 3-deoxy-α-D-manno-oct-2-ulosonic acid and rhamnose.
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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipopolysaccharide core region biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipopolysaccharide core region biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
lipopolysaccharide core biosynthesis protein WaaZ
NP_418081.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3799345..3800196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418081.1 lipopolysaccharide core biosynthesis protein WaaZ [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418081.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8Q793
    Conserved Domains (1) summary
    PRK09822
    Location:1 → 269
    PRK09822; lipopolysaccharide core biosynthesis protein; Provisional
Nucleotide Protein
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