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gabD succinate-semialdehyde dehydrogenase (NADP(+)) GabD [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948060, updated on 30-Jul-2025
Official Symbol
gabD
Official Full Name
succinate-semialdehyde dehydrogenase (NADP(+)) GabD
Primary source
ECOCYC:EG11329
Locus tag
b2661
See related
ASAP:ABE-0008758
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2655
Summary
Escherichia coli K-12 encodes two succinate semialdehyde dehydrogenases which differ in their ability to utilize NAD+ and NADP+. [More information is available at EcoCyc: EG11329].
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Sequence:
NC_000913.3 (2791273..2792721)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene glutarate dioxygenase GlaH Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene 4-aminobutyrate aminotransferase GabT Neighboring gene 4-aminobutanoate:H(+) symporter

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions. Langendorf CG, et al. PLoS One, 2010 Feb 18. PMID 20174634, Free PMC Article
  2. Crystal structure of non-redox regulated SSADH from Escherichia coli. Ahn JW, et al. Biochem Biophys Res Commun, 2010 Jan 29. PMID 20060383
  3. Saturation transfer difference NMR studies on substrates and inhibitors of succinic semialdehyde dehydrogenases. Jaeger M, et al. Biochem Biophys Res Commun, 2008 Aug 1. PMID 18474219
  4. Separation and characterization of NAD- and NADP-specific succinate-semialdehyde dehydrogenase from Escherichia coli K-12 3300. Cozzani I, et al. Biochim Biophys Acta, 1980 Jun 13. PMID 7004491
  5. Two succinic semialdehyde dehydrogenases are induced when Escherichia coli K-12 Is grown on gamma-aminobutyrate. Donnelly MI, et al. J Bacteriol, 1981 Mar. PMID 7009588, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that a deletion of three amino acids in gabD gene (SSADH) permits this enzyme to use NADP+.
    Title: The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions.
  2. the crystal structure of EcSSADH, revealing that the catalytic loop of EcSSADH, unlike that of human SSADH, was presented.
    Title: Crystal structure of non-redox regulated SSADH from Escherichia coli.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NADP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutarate-semialdehyde dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutarate-semialdehyde dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables succinate-semialdehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinate-semialdehyde dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables succinate-semialdehyde dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables succinate-semialdehyde dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables succinate-semialdehyde dehydrogenase [NAD(P)+] activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables succinate-semialdehyde dehydrogenase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular detoxification TAS
Traceable Author Statement
more info
 PubMed 
involved_in gamma-aminobutyric acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gamma-aminobutyric acid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in gamma-aminobutyric acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within gamma-aminobutyric acid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein homotetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
succinate-semialdehyde dehydrogenase (NADP(+)) GabD
NP_417147.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2791273..2792721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417147.1 succinate-semialdehyde dehydrogenase (NADP(+)) GabD

    See identical proteins and their annotated locations for NP_417147.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1V2GJV3
    Conserved Domains (1) summary
    PRK11241
    Location:1 → 482
    gabD; NADP-dependent succinate-semialdehyde dehydrogenase I
Nucleotide Protein
Heading Accession and Version

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