U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

kdgK 2-dehydro-3-deoxygluconokinase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948041, updated on 26-Jun-2024

Summary

Go to the top of the page Help
Gene symbol
kdgK
Gene description
2-dehydro-3-deoxygluconokinase
Primary source
ASAP:ABE-0011519
Locus tag
b3526
See related
ECOCYC:EG12253
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3511; yhjI
Summary
KdgK is elevated 3-5X during growth at 4C (enabled by Oleispira antarctica Cpn10/60 transgene). [More information is available at EcoGene: EG12253]. 2-keto-3-deoxygluconokinase catalyzes the ATP-dependent phosphorylation of the first common intermediate in the D-glucuronate and D-galacturonate degradation pathways, 2-dehydro-3-deoxy-D-gluconate . [More information is available at EcoCyc: EG12253].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (3679419..3680348)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene AsmA family protein YhjG Neighboring gene c-di-GMP phosphodiesterase PdeH Neighboring gene peptidase M16 family protein YhjJ Neighboring gene C4 dicarboxylate/orotate:H(+) symporter

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Uronic acid metabolism in bacteria. IV. Purification and properties of 2-keto-3-deoxy-D-gluconokinase in Escherichia coli. CYNKIN MA, et al. J Biol Chem, 1960 Jun. PMID 13813474
  2. [A common pathway for hexouronate degradation in Escherichia coli K 12. Induction mechanism of 2-keto-3-deoxy-gluconate metabolizing enzymes]. Pouysségur JM, et al. Eur J Biochem, 1972 Nov 7. PMID 4565407
  3. Genetic control of the 2-keto-3-deoxy-d-gluconate metabolism in Escherichia coli K-12: kdg regulon. Pouyssegur J, et al. J Bacteriol, 1974 Feb. PMID 4359651, Free PMC Article
  4. Comparative genomics of the KdgR regulon in Erwinia chrysanthemi 3937 and other gamma-proteobacteria. Rodionov DA, et al. Microbiology (Reading), 2004 Nov. PMID 15528647
  5. Study of the common degradative pathway of hexuronates in Escherichia coli K 12. Purification, properties and individuality of 2-keto-3-deoxy-D-gluconnokinase. Pouyssegur J, et al. Biochimie, 1971. PMID 4944816

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2-dehydro-3-deoxygluconokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2-dehydro-3-deoxygluconokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2-dehydro-3-deoxygluconokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in D-galacturonate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within D-galacturonate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in D-glucuronate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within D-glucuronate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in carbohydrate phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
2-dehydro-3-deoxygluconokinase
NP_417983.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3679419..3680348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417983.2 2-dehydro-3-deoxygluconokinase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417983.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AN08, A0A8S7HUP5, A0AAD2NU94
    Conserved Domains (1) summary
    cd01166
    Location:4 → 301
    KdgK; 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the ...
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.