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pabA aminodeoxychorismate synthase subunit 2 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947873, updated on 17-Jul-2025
Official Symbol
pabA
Official Full Name
aminodeoxychorismate synthase subunit 2
Primary source
ECOCYC:EG10682
Locus tag
b3360
See related
ASAP:ABE-0010983
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3348
Summary
Component II provides the glutamine amidotransferase activity. [More information is available at EcoCyc: EG10682].
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Sequence:
NC_000913.3 (3490266..3490829, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transporter YhfK Neighboring gene N-acetylornithine aminotransferase/N-succinyldiaminopimelate aminotransferase Neighboring gene protein YrfJ Neighboring gene putative adenosine monophosphate--protein transferase Fic Neighboring gene DUF2559 domain-containing protein YhfG Neighboring gene peptidyl-prolyl cis-trans isomerase A

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Biosynthesis of 4-aminobenzoate in Escherichia coli. Huang M, et al. J Bacteriol, 1970 Jun. PMID 4914080, Free PMC Article
  2. Nucleotide sequence of Escherichia coli pabA and its evolutionary relationship to trp(G)D. Kaplan JB, et al. J Mol Biol, 1983 Aug 15. PMID 6350604
  3. p-aminobenzoate synthesis in Escherichia coli: kinetic and mechanistic characterization of the amidotransferase PabA. Roux B, et al. Biochemistry, 1992 Aug 4. PMID 1637823
  4. Chorismate aminations: partial purification of Escherichia coli PABA synthase and mechanistic comparison with anthranilate synthase. Walsh CT, et al. Biochemistry, 1987 Jul 28. PMID 3311153
  5. Escherichia coli aminodeoxychorismate synthase: analysis of pabB mutations affecting catalysis and subunit association. Rayl EA, et al. Biochim Biophys Acta, 1996 Jun 7. PMID 8679677

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4-amino-4-deoxychorismate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4-amino-4-deoxychorismate synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to anthranilate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within 4-aminobenzoate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in L-tryptophan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in aromatic amino acid family biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in folic acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tetrahydrofolate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tetrahydrofolate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tetrahydrofolate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of aminodeoxychorismate synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of aminodeoxychorismate synthase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
aminodeoxychorismate synthase subunit 2
NP_417819.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3490266..3490829 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417819.1 aminodeoxychorismate synthase subunit 2

    See identical proteins and their annotated locations for NP_417819.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A444R1R4
    Conserved Domains (1) summary
    PRK08007
    Location:1 → 187
    PRK08007; aminodeoxychorismate synthase component 2
Nucleotide Protein
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