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rplW [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947819, updated on 11-Sep-2024

Summary

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Official Symbol
rplW
Primary source
ECOCYC:EG10883
Locus tag
b3318
See related
ASAP:ABE-0010856
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3305
Summary
The L23 protein is a component of the 50S subunit of the ribosome and provides a chaperone docking site that links protein biosynthesis with protein folding. [More information is available at EcoCyc: EG10883].
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Genomic context

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Sequence:
NC_000913.3 (3451382..3451684, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 30S ribosomal subunit protein S19 Neighboring gene 50S ribosomal subunit protein L2 Neighboring gene 50S ribosomal subunit protein L4 Neighboring gene 50S ribosomal subunit protein L3 Neighboring gene 30S ribosomal subunit protein S10

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A conserved motif is prerequisite for the interaction of NAC with ribosomal protein L23 and nascent chains. Wegrzyn RD, et al. J Biol Chem, 2006 Feb 3. PMID 16316984
  2. Ribosome-based protein folding systems are structurally divergent but functionally universal across biological kingdoms. Ito K. Mol Microbiol, 2005 Jul. PMID 15978066
  3. Simultaneous binding of trigger factor and signal recognition particle to the E. coli ribosome. Raine A, et al. Biochimie, 2004 Jul. PMID 15308339
  4. Where chaperones and nascent polypeptides meet. Albanèse V, et al. Nat Struct Biol, 2002 Oct. PMID 12352951
  5. Structure of a protein L23-RNA complex located at the A-site domain of the ribosomal peptidyl transferase centre. Vester B, et al. J Mol Biol, 1984 Nov 5. PMID 6392564

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here, theauthors show that the C-terminal helix of the signal-sequence-binding domain of signal recognition particle penetrates into the ribosomal tunnel and contacts the intra-tunnel loop of ribosomal protein uL23.
    Title: The signal recognition particle contacts uL23 and scans substrate translation inside the ribosomal tunnel.
  2. N-terminus verified by Edman degradation on complete protein
    Title: Primary structure of protein L23 from the Escherichia coli ribosome.
  3. nascent polypeptide-associated complex employs a conserved ribosome binding domain to position itself on the L23 ribosomal protein adjacent to the nascent polypeptide exit site.
    Title: A conserved motif is prerequisite for the interaction of NAC with ribosomal protein L23 and nascent chains.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
50S ribosomal subunit protein L23

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3451382..3451684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417777.1 50S ribosomal subunit protein L23 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417777.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9APF0
    Conserved Domains (1) summary
    PRK05738
    Location:8 → 99
    rplW; 50S ribosomal protein L23; Reviewed
Nucleotide Protein
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