secY Sec translocon subunit SecY [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: secY
Official Full Name: Sec translocon subunit SecY
Primary source: ECOCYC:EG10766
Locus tag: b3300
See related: ASAP:ABE-0010814
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK3287; prlA
Summary: SecYEG complex interacts with SecDFyajC to form a hexameric holocomplex. [More information is available at EcoGene: EG10766]. SecY is a protein involved in the Sec protein secretion pathway. [More information is available at EcoCyc: EG10766].
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Genomic context

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Sequence:: NC_000913.3 (3442766..3444097, complement)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comparison of Single and Multiple Turnovers of SecYEG in Escherichia coli.
Title: Comparison of Single and Multiple Turnovers of SecYEG in Escherichia coli.
SecY-mediated quality control prevents the translocation of non-gated porins.
Title: SecY-mediated quality control prevents the translocation of non-gated porins.
Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation.
Title: Two-way communication between SecY and SecA suggests a Brownian ratchet mechanism for protein translocation.
SecA gains access to the SecYEG complex via a lipid-bound intermediate state, whereas acidic phospholipids allosterically activate SecA for ATP-dependent protein translocation.
Title: Lipids Activate SecA for High Affinity Binding to the SecYEG Complex.
Authors show that SecG plays a critical role for the residual export mediated by mutant signal sequences and that the SecYE dimer can often be detected only in the presence of SecG.
Title: Escherichia coli SecG is required for residual export mediated by mutant signal sequences and for SecY-SecE complex stability.
Study shows that SecA moves polypeptides through the SecY channel by a "push and slide" mechanism. In its ATP-bound state, SecA interacts through a two-helix finger with a subset of amino acids in a substrate, pushing them into the channel.
Title: A "push and slide" mechanism allows sequence-insensitive translocation of secretory proteins by the SecA ATPase.
These data suggest that wild-type YidC residues (G355 and M471) participate in interactions, direct or indirect, with SecY.
Title: Identification of YidC residues that define interactions with the Sec Apparatus.
The hydrophobicity threshold for SecYEG-mediated cell membrane insertion is distinctly lower than that for Sec61-mediated insertion.
Title: Quantitative analysis of SecYEG-mediated insertion of transmembrane α-helices into the bacterial inner membrane.
Data show that ribosome binding is sufficient to open the SecYEG channel.
Title: The bacterial translocon SecYEG opens upon ribosome binding.
Data indicate taht SecG inversion occurs only when MPIase associates with SecYEG.
Title: Glycolipozyme MPIase is essential for topology inversion of SecG during preprotein translocation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables signal sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables signal sequence binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within SRP-dependent cotranslational protein targeting to membrane, translocation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intracellular protein transmembrane transport	EXP Inferred from Experiment more info	PubMed
acts_upstream_of_or_within intracellular protein transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular protein transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular protein transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein insertion into membrane from inner side	IDA Inferred from Direct Assay more info	PubMed
involved_in protein insertion into membrane from inner side	IDA Inferred from Direct Assay more info	PubMed
involved_in protein targeting	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport by the Sec complex	IDA Inferred from Direct Assay more info	PubMed
involved_in protein transport by the Sec complex	IDA Inferred from Direct Assay more info	PubMed
involved_in protein transport by the Sec complex	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport by the Sec complex	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of cell envelope Sec protein transport complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cell envelope Sec protein transport complex	IDA Inferred from Direct Assay more info	PubMed
part_of cell envelope Sec protein transport complex	IPI Inferred from Physical Interaction more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: Sec translocon subunit SecY

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

3442766..3444097 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_417759.1 Sec translocon subunit SecY [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_417759.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A1V2GIN7

Conserved Domains (1) summary

PRK09204
Location:18 → 433

secY; preprotein translocase subunit SecY; Reviewed