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cyaY frataxin CyaY [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947754, updated on 10-Oct-2024

Summary

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Official Symbol
cyaY
Official Full Name
frataxin CyaY
Primary source
ECOCYC:EG11653
Locus tag
b3807
See related
ASAP:ABE-0012435
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3801
Summary
Frataxin-related. [More information is available at EcoGene: EG11653]. CyaY is a protein with similarity to human frataxin, mutations in which are responsible for Friedreich's ataxia. [More information is available at EcoCyc: EG11653].
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Genomic context

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Sequence:
NC_000913.3 (3993739..3994059, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene uroporphyrinogen-III synthase Neighboring gene hydroxymethylbilane synthase Neighboring gene adenylate cyclase Neighboring gene protein YzcX Neighboring gene putative lipoprotein YifL Neighboring gene diaminopimelate epimerase Neighboring gene DUF484 domain-containing protein YigA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The phylogenetic distribution of frataxin indicates a role in iron-sulfur cluster protein assembly. Huynen MA, et al. Hum Mol Genet, 2001 Oct 1. PMID 11689493
  2. NMR assignment of the 1H, 15N and 13C resonances of the E. coli frataxin orthologue, CyaY. Nair M, et al. J Biomol NMR, 2003 Dec. PMID 14512742
  3. Iron binding and oxidation kinetics in frataxin CyaY of Escherichia coli. Bou-Abdallah F, et al. J Mol Biol, 2004 Aug 6. PMID 15276847
  4. Solution structure of the bacterial frataxin ortholog, CyaY: mapping the iron binding sites. Nair M, et al. Structure, 2004 Nov. PMID 15530368
  5. Crystallization and preliminary X-ray crystallographic analysis of Escherichia coli CyaY, a structural homologue of human frataxin. Lee MG, et al. Acta Crystallogr D Biol Crystallogr, 2000 Jul. PMID 10930845

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We have demonstrated that a single mutation in the scaffold protein IscU rendered E. coli viability strictly dependent upon a functional CyaY.
    Title: Turning Escherichia coli into a Frataxin-Dependent Organism.
  2. CyaY potentiates E. coli fitness, belongs to the ISC pathway catalyzing the maturation of Fe-S cluster-containing proteins and requires iron-rich conditions for its contribution to be significant; a genetic interaction was discovered between cyaY and iscX
    Title: The iron-binding CyaY and IscX proteins assist the ISC-catalyzed Fe-S biogenesis in Escherichia coli.
  3. CyaY participates in iron-sulfur (Fe-S) cluster assembly as an iron-dependent inhibitor of cluster formation, through binding to the desulfurase IscS.
    Title: Bacterial frataxin CyaY is the gatekeeper of iron-sulfur cluster formation catalyzed by IscS.
  4. CyaY is located in the cytoplasm
    Title: Effects of the deletion of the Escherichia coli frataxin homologue CyaY on the respiratory NADH:ubiquinone oxidoreductase.
  5. IscA recruits intracellular iron for the iron-sulfur cluster assembly under normal physiological conditions, whereas CyaY may serve as an iron chaperon to sequester redox active free iron under oxidative stress conditions
    Title: Distinct iron binding property of two putative iron donors for the iron-sulfur cluster assembly: IscA and the bacterial frataxin ortholog CyaY under physiological and oxidative stress conditions.
  6. Escherichia coli CYaY is an iron donor for the assembly of [2Fe-2S] clusters in the scaffold IscU
    Title: Iron-sulfur cluster biosynthesis: characterization of Escherichia coli CYaY as an iron donor for the assembly of [2Fe-2S] clusters in the scaffold IscU.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ferric iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferric iron binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferric iron binding IEA
Inferred from Electronic Annotation
more info
  
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferrous iron binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in iron-sulfur cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within iron-sulfur cluster assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in iron-sulfur cluster assembly IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within iron-sulfur cluster assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
frataxin CyaY

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3993739..3994059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418251.1 frataxin CyaY [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418251.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AR44, A0AAQ2LQW8
    Conserved Domains (1) summary
    PRK00446
    Location:1 → 106
    cyaY; frataxin-like protein; Provisional
Nucleotide Protein
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