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hldE fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947548, updated on 9-Mar-2022

Summary

Gene symbol
hldE
Gene description
fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase
Primary source
ASAP:ABE-0010015
Locus tag
b3052
See related
ECOCYC:G7590
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3042; gmhC; rfaE; waaE; yqiF
Summary
HldE is a bifunctional protein with an N-terminal ribokinase superfamily domain and a C-terminal cytidylyltransferase superfamily domain; the two domains are genetically separable . [More information is available at EcoCyc: G7590].
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Genomic context

Sequence:
NC_000913.3 (3195320..3196753, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene putative toxic peptide IbsD Neighboring gene ncRNA Neighboring gene toxic peptide IbsE Neighboring gene fused glutamine synthetase deadenylase/glutamine synthetase adenylyltransferase Neighboring gene inorganic triphosphatase

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables heptose 7-phosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heptose 7-phosphate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables heptose 7-phosphate kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables heptose-1-phosphate adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heptose-1-phosphate adenylyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables heptose-1-phosphate adenylyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase
NP_417524.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3195320..3196753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417524.1 fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417524.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P76658
    Conserved Domains (1) summary
    PRK11316
    Location:1473
    PRK11316; bifunctional D-glycero-beta-D-manno-heptose-7-phosphate kinase/D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase HldE