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prpC 2-methylcitrate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947528, updated on 19-Sep-2024

Summary

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Official Symbol
prpC
Official Full Name
2-methylcitrate synthase
Primary source
ECOCYC:G6198
Locus tag
b0333
See related
ASAP:ABE-0001148
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0330; yahS; yzzD
Summary
Repressed during biofilm formation. [More information is available at EcoGene: EG11756]. Regulation has been described . [More information is available at EcoCyc: G6198].
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Genomic context

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Sequence:
NC_000913.3 (350012..351181)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator PrpR Neighboring gene 2-methylisocitrate lyase Neighboring gene 2-methylcitrate dehydratase Neighboring gene propionyl-CoA synthetase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Model-driven discovery of underground metabolic functions in Escherichia coli. Guzmán GI, et al. Proc Natl Acad Sci U S A, 2015 Jan 20. PMID 25564669, Free PMC Article
  2. Carbon-13 nuclear magnetic resonance study of metabolism of propionate by Escherichia coli. London RE, et al. J Bacteriol, 1999 Jun. PMID 10348870, Free PMC Article
  3. Citrate synthase and 2-methylcitrate synthase: structural, functional and evolutionary relationships. Gerike U, et al. Microbiology (Reading), 1998 Apr. PMID 9579066
  4. Does Escherichia coli possess a second citrate synthase gene? Patton AJ, et al. Eur J Biochem, 1993 May 15. PMID 8508809
  5. Salmonella typhimurium LT2 catabolizes propionate via the 2-methylcitric acid cycle. Horswill AR, et al. J Bacteriol, 1999 Sep. PMID 10482501, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Does Escherichia coli possess a second citrate synthase gene?
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2-methylcitrate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2-methylcitrate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2-methylcitrate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, acyl groups converted into alkyl on transfer IEA
Inferred from Electronic Annotation
more info
  
enables citrate (Si)-synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables citrate (Si)-synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables citrate (Si)-synthase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables citrate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in propionate metabolic process, methylcitrate cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within propionate metabolic process, methylcitrate cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in propionate metabolic process, methylcitrate cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
2-methylcitrate synthase
NP_414867.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    350012..351181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414867.1 2-methylcitrate synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414867.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376X4G5
    Conserved Domains (1) summary
    PRK12351
    Location:15 → 388
    PRK12351; methylcitrate synthase; Provisional
Nucleotide Protein
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Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials