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tolC outer membrane channel TolC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947521, updated on 5-Jan-2023

Summary

Gene symbol
tolC
Gene description
outer membrane channel TolC
Primary source
ASAP:ABE-0009965
Locus tag
b3035
See related
ECOCYC:EG11009
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
colE1-i; ECK3026; mtcB; mukA; refI; toc; weeA
Summary
TolC, MdtQ, MdtP and CusC are paralogs. [More information is available at EcoGene: EG11009]. TolC is an outer membrane porin involved in the efflux of several hydrophobic and amphipathic molecules. [More information is available at EcoCyc: EG11009].
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Genomic context

Sequence:
NC_000913.3 (3178115..3179596)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1249 domain-containing protein YqiB Neighboring gene ADP-sugar pyrophosphatase Neighboring gene DUF1190 domain-containing protein YgiB Neighboring gene putative acid--amine ligase YgiC

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables bile acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables efflux transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables efflux transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables efflux transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables enterobactin transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables porin activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables porin activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of MacAB-TolC complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
 
part_of efflux pump complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of efflux pump complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
outer membrane channel TolC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3178115..3179596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417507.2 outer membrane channel TolC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417507.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P02930
    Conserved Domains (1) summary
    PRK09465
    Location:1451
    tolC; outer membrane channel protein; Reviewed