dkgA methylglyoxal reductase DkgA [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: dkgA
Official Full Name: methylglyoxal reductase DkgA
Primary source: ECOCYC:G7565
Locus tag: b3012
See related: ASAP:ABE-0009892
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK3004; yqhE
Summary: DkgA has been shown to have a stereoselective beta-keto ester reductase and methylglyxoal reductase activity. [More information is available at EcoCyc: G7565].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Purified enzymes encoded by yqhD and dkgA were shown to have NADPH-dependent furfural reductase activity.
Title: Silencing of NADPH-dependent oxidoreductase genes (yqhD and dkgA) in furfural-resistant ethanologenic Escherichia coli.
N-terminus verified by Edman degradation on mature peptide
Title: Purification and identification of an Escherichia coli beta-keto ester reductase as 2,5-diketo-D-gluconate reductase YqhE.
Crystallization and xray diffraction of the recombinant protein.
Title: Crystal structure of Escherichia coli DkgA, a broad-specificity aldo-keto reductase.

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Function	Evidence Code	Pubs
enables 2,5-didehydrogluconate reductase activity	IEA Inferred from Electronic Annotation more info
enables alcohol dehydrogenase (NADP+) activity	IDA Inferred from Direct Assay more info	PubMed
enables aldose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-ascorbic acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in methylglyoxal catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within methylglyoxal catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

NP_417485.4

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