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argO L-arginine exporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947418, updated on 19-Sep-2024

Summary

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Official Symbol
argO
Official Full Name
L-arginine exporter
Primary source
ECOCYC:EG11159
Locus tag
b2923
See related
ASAP:ABE-0009591
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2919; yggA
Summary
LysE family. [More information is available at EcoGene: EG11159]. The ArgO (YggA) protein is a member of the LysE family of lysine efflux transporters . [More information is available at EcoCyc: EG11159].
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Genomic context

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Sequence:
NC_000913.3 (3068173..3068808, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene propionyl-CoA:succinate CoA transferase Neighboring gene putative DNA-binding transcriptional regulator YgfI Neighboring gene DUF541 domain-containing protein YggE Neighboring gene small conductance mechanosensitive channel MscS Neighboring gene fructose-bisphosphate aldolase class II

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Topology of the l-Arginine Exporter ArgO Conforms to an Nin-Cout Configuration in Escherichia coli: Requirement for the Cytoplasmic N-Terminal Domain, Functional Helical Interactions, and an Aspartate Pair for ArgO Function. Pathania A, et al. J Bacteriol, 2016 Dec 1. PMID 27645388, Free PMC Article
  2. Environmental regulation operating at the promoter clearance step of bacterial transcription. Laishram RS, et al. Genes Dev, 2007 May 15. PMID 17504942, Free PMC Article
  3. Competitive activation of the Escherichia coli argO gene coding for an arginine exporter by the transcriptional regulators Lrp and ArgP. Peeters E, et al. Mol Microbiol, 2009 Dec. PMID 19906180
  4. Identification, molecular cloning and sequence analysis of a gene cluster encoding the class II fructose 1,6-bisphosphate aldolase, 3-phosphoglycerate kinase and a putative second glyceraldehyde 3-phosphate dehydrogenase of Escherichia coli. Alefounder PR, et al. Mol Microbiol, 1989 Jun. PMID 2546007
  5. Evidence for an arginine exporter encoded by yggA (argO) that is regulated by the LysR-type transcriptional regulator ArgP in Escherichia coli. Nandineni MR, et al. J Bacteriol, 2004 Jun. PMID 15150242, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A pair of conserved aspartate residues, located near the opposing edges of ArgO plays a pivotal role in facilitating transmembrane Arg flux.
    Title: The Topology of the l-Arginine Exporter ArgO Conforms to an Nin-Cout Configuration in Escherichia coli: Requirement for the Cytoplasmic N-Terminal Domain, Functional Helical Interactions, and an Aspartate Pair for ArgO Function.
  2. Activation by Lrp interferes with the previously demonstrated activation of the argO promoter by ArgP.
    Title: Competitive activation of the Escherichia coli argO gene coding for an arginine exporter by the transcriptional regulators Lrp and ArgP.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-arginine transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables L-arginine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in L-arginine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within L-arginine transmembrane transport IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within L-arginine transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
L-arginine exporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3068173..3068808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417398.1 L-arginine exporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417398.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    W8T9S8
    Conserved Domains (1) summary
    PRK09304
    Location:1 → 207
    PRK09304; arginine exporter ArgO
Nucleotide Protein
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