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THEMIS2 thymocyte selection associated family member 2 [ Homo sapiens (human) ]

Gene ID: 9473, updated on 5-Aug-2018

Summary

Official Symbol
THEMIS2provided by HGNC
Official Full Name
thymocyte selection associated family member 2provided by HGNC
Primary source
HGNC:HGNC:16839
See related
Ensembl:ENSG00000130775 MIM:617856; Vega:OTTHUMG00000003735
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ICB1; ICB-1; C1orf38
Expression
Broad expression in bone marrow (RPKM 58.1), spleen (RPKM 43.6) and 17 other tissues See more
Orthologs

Genomic context

See THEMIS2 in Genome Data Viewer
Location:
1p35.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (27872531..27886685)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (28199055..28213196)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1245, pseudogene Neighboring gene protein phosphatase 1 regulatory subunit 8 Neighboring gene small Cajal body-specific RNA 1 Neighboring gene replication protein A2 Neighboring gene sphingomyelin phosphodiesterase acid like 3B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein THEMIS2
Names
basement membrane-induced
induced by contact to basement membrane 1 protein
protein ICB-1
thymocyte-expressed molecule involved in selection protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039477.2NP_001034566.1  protein THEMIS2 isoform 2

    See identical proteins and their annotated locations for NP_001034566.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two coding exons, as compared to variant 3. The resulting isoform (2) has a much shorter and distinct C-terminus, compared to isoform 3.
    Source sequence(s)
    AL109927
    Consensus CDS
    CCDS30654.1
    UniProtKB/Swiss-Prot
    Q5TEJ8
    Related
    ENSP00000363037.3, OTTHUMP00000003993, ENST00000373927.7, OTTHUMT00000011151
    Conserved Domains (1) summary
    pfam12736
    Location:1862
    CABIT; Cell-cycle sustaining, positive selection,
  2. NM_001105556.2NP_001099026.1  protein THEMIS2 isoform 3

    See identical proteins and their annotated locations for NP_001099026.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AL109927, AL554503, BI908174
    Consensus CDS
    CCDS41290.1
    UniProtKB/Swiss-Prot
    Q5TEJ8
    Related
    ENSP00000363031.3, OTTHUMP00000003991, ENST00000373921.7, OTTHUMT00000011148
    Conserved Domains (1) summary
    pfam12736
    Location:265511
    CABIT; Cell-cycle sustaining, positive selection,
  3. NM_001286113.1NP_001273042.1  protein THEMIS2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an internal segment but maintains the reading frame compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AK303090, AL109927
    Consensus CDS
    CCDS65461.1
    UniProtKB/Swiss-Prot
    Q5TEJ8
    Related
    ENSP00000329862.7, ENST00000328928.11
    Conserved Domains (1) summary
    pfam12736
    Location:18235
    CABIT; Cell-cycle sustaining, positive selection,
  4. NM_001286115.1NP_001273044.1  protein THEMIS2 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an altenate in-frame splice site compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AK303141, AL109927
    UniProtKB/Swiss-Prot
    Q5TEJ8
    Conserved Domains (1) summary
    pfam12736
    Location:18315
    CABIT; Cell-cycle sustaining, positive selection,
  5. NM_004848.3NP_004839.2  protein THEMIS2 isoform 1

    See identical proteins and their annotated locations for NP_004839.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an coding exon, as compared to variant 3. The resulting isoform (1) has a much shorter and distinct C-terminus, compared to isoform 3.
    Source sequence(s)
    AL109927, BC031655
    Consensus CDS
    CCDS30653.1
    UniProtKB/Swiss-Prot
    Q5TEJ8
    Related
    ENSP00000363035.1, OTTHUMP00000003850, ENST00000373925.5, OTTHUMT00000010529
    Conserved Domains (1) summary
    pfam12736
    Location:18239
    CABIT; Cell-cycle sustaining, positive selection,

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    27872531..27886685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246041.3XP_005246098.1  protein THEMIS2 isoform X2

    Conserved Domains (1) summary
    pfam12736
    Location:128374
    CABIT; Cell-cycle sustaining, positive selection,
  2. XM_011542445.2XP_011540747.1  protein THEMIS2 isoform X1

    See identical proteins and their annotated locations for XP_011540747.1

    Conserved Domains (1) summary
    pfam12736
    Location:218464
    CABIT; Cell-cycle sustaining, positive selection,
  3. XM_006711050.1XP_006711113.1  protein THEMIS2 isoform X3

    See identical proteins and their annotated locations for XP_006711113.1

    UniProtKB/Swiss-Prot
    Q5TEJ8
    Conserved Domains (1) summary
    pfam12736
    Location:18235
    CABIT; Cell-cycle sustaining, positive selection,
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