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emrA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947166, updated on 11-Sep-2024

Summary

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Official Symbol
emrA
Primary source
ECOCYC:EG11354
Locus tag
b2685
See related
ASAP:ABE-0008838
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2679
Summary
EmrA is the membrane fusion protein for the EmrB multidrug efflux pump. [More information is available at EcoCyc: EG11354].
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Genomic context

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Sequence:
NC_000913.3 (2811427..2812599)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene L-valine exporter, YgaZ component Neighboring gene L-valine exporter, YgaH component Neighboring gene DNA-binding transcriptional regulator MprA Neighboring gene multidrug efflux pump membrane subunit EmrB Neighboring gene S-ribosylhomocysteine lyase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural characterization of the EmrAB-TolC efflux complex from E. coli. Yousefian N, et al. Biochim Biophys Acta Biomembr, 2021 Jan 1. PMID 33065135
  2. Identification of oligomerization and drug-binding domains of the membrane fusion protein EmrA. Borges-Walmsley MI, et al. J Biol Chem, 2003 Apr 11. PMID 12482849
  3. The EmrR protein represses the Escherichia coli emrRAB multidrug resistance operon by directly binding to its promoter region. Xiong A, et al. Antimicrob Agents Chemother, 2000 Oct. PMID 10991887, Free PMC Article
  4. Purification and ligand binding of EmrR, a regulator of a multidrug transporter. Brooun A, et al. J Bacteriol, 1999 Aug. PMID 10438794, Free PMC Article
  5. Differential regulation of the mcb and emr operons of Escherichia coli: role of mcb in multidrug resistance. Lomovskaya O, et al. Antimicrob Agents Chemother, 1996 Apr. PMID 8849229, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural characterization of the EmrAB-TolC efflux complex from E. coli.
    Title: Structural characterization of the EmrAB-TolC efflux complex from E. coli.
  2. Data suggest that recruitment of TolC by various MFPs AcrA, MacA, and EmrA is determined not only by kinetics of MFP-TolC interactions but also by oligomerization kinetics of MFPs and pH.
    Title: Kinetic control of TolC recruitment by multidrug efflux complexes.
  3. This study was aimed to obtain a reliable estimate of the stoichiometry of the EmrAB complex.
    Title: The multidrug resistance efflux complex, EmrAB from Escherichia coli forms a dimer in vitro.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables bile acid transmembrane transporter activity EXP
Inferred from Experiment
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables xenobiotic transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bile acid and bile salt transport EXP
Inferred from Experiment
more info
 PubMed 
involved_in response to antibiotic IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to antibiotic IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to antibiotic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to steroid hormone EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within response to toxic substance IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to toxic substance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in xenobiotic detoxification by transmembrane export across the cell outer membrane NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within xenobiotic detoxification by transmembrane export across the plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of efflux pump complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in outer membrane-bounded periplasmic space ISM
Inferred from Sequence Model
more info
 PubMed 
located_in periplasmic side of plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
multidrug efflux pump membrane fusion protein EmrA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2811427..2812599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417170.1 multidrug efflux pump membrane fusion protein EmrA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417170.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A826PFZ7
    Conserved Domains (1) summary
    PRK15136
    Location:1 → 390
    PRK15136; multidrug efflux MFS transporter periplasmic adaptor subunit EmrA
Nucleotide Protein
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